Reflexiones universitarias. San Pedro Valencia: renovación urbana, saneamiento ambiental y emprendimientos turísticos. Otoño 2015

Los trabajos que aquí se presentan se elaboraron por las y los estudiantes como parte de las actividades del Proyecto de Aplicación Profesional (PAP) “San Pedro Valencia: renovación urbana, saneamiento ambiental y emprendimientos turísticos”, durante el periodo de Otoño de 2015. A lo largo del periodo los autores compartieron sus reflexiones en torno a su percepción sobre el contexto en el que actúa el PAP; sobre las alternativas posibles a la problemática detectada y lo que significa pensar una alternativa; sobre los sujetos con los que se ha interactuado a lo largo de la experiencia de trabajo y sobre el papel del profesionista y del ciudadano en un mundo como el que nos tocó vivir. La obra está compuesta por reflexiones personales de las y los estudiantes que, explorando estas temáticas, comparten sus aprendizajes y observaciones de forma vívida.ITESO, A.C

Experiencias de vinculación universitaria desde la formación, la intervención social y la investigación (Complexus 10)

La edición revela experiencias universitarias que analizan y proponen soluciones a problemas sociales mediante la acción colectiva. Muestra la fusión de saberes académicos, experiencias de diversos actores y esfuerzos de la sociedad que se entretejen para construir un mundo más justo y más humano.ITESO, A.C

Regeneración de Sedum praealtum A.DC (siempreviva) vía organogénesis

Introduction: Dalbergia congestiflora Pittier (campincerán) is used to make musical instruments in Michoacán (Mexico), so this specie is considered overexploited and at risk of extinction. Propagation studies of campincerán are scarce, but the factors that could affect the propagation by stem cuttings of this species are auxin exogenous concentration and position of the stem cuttings (apical, media and basal). The hypothesis tested is that a higher sprouting and rooting at concentrations between 1 and 10 ppm of indolbutyric acid (IBA) and the basal stem cuttings are observed. Method: The stem cuttings of D. congestiflora were collected in Tacámbaro, Michoacán. The apical, middle and basal cuttings were placed in a rooting solution of 1, 5 and 10 ppm of IBA. The variables studied were the sprouting percentage, the mean number of sprouts and the mean length of the sprouts after 15, 45 and 75 days, while the percentage of rooting was evaluated after 150 days. Results: The sprouting percentage, mean number of sprouts and mean length of sprouts were higher in basal cuttings in relation to the apical and meddle cuttings. The rooting was observed only at basal cuttings with 10 ppm of IBA. Conclusion: The sprouting of cuttings was observed at low cocentrations of IBA and this is independent of position stem cuttings, but the rooting occurred only at 10 ppm of IBA

Enolase from Aspergillus fumigatus is a moonlighting protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen

The opportunistic fungal pathogen Aspergillus fumigatus can cause severe infections, particularly in immunocompromised individuals. Upon infection, A. fumigatus faces the powerful and directly acting immune defense of the human host. The mechanisms on how A. fumigatus evades innate immune attack and complement are still poorly understood. Here, we identify A. fumigatus enolase, AfEno1, which was also characterized as fungal allergen, as a surface ligand for human plasma complement regulators. AfEno1 binds factor H, factor-H-like protein 1 (FHL-1), C4b binding protein (C4BP), and plasminogen. Factor H attaches to AfEno1 via two regions, via short conserved repeats (SCRs) 6–7 and 19–20, and FHL-1 contacts AfEno1 via SCRs 6–7. Both regulators when bound to AfEno1 retain cofactor activity and assist in C3b inactivation. Similarly, the classical pathway regulator C4BP binds to AfEno1 and bound to AfEno1; C4BP assists in C4b inactivation. Plasminogen which binds to AfEno1 via lysine residues is accessible for the tissue-type plasminogen activator (tPA), and active plasmin cleaves the chromogenic substrate S2251, degrades fibrinogen, and inactivates C3 and C3b. Plasmin attached to swollen A. fumigatus conidia damages human A549 lung epithelial cells, reduces the cellular metabolic activity, and induces cell retraction, which results in exposure of the extracellular matrix. Thus, A. fumigatus AfEno1 is a moonlighting protein and virulence factor which recruits several human regulators. The attached human regulators allow the fungal pathogen to control complement at the level of C3 and to damage endothelial cell layers and tissue components