Causal Bulk Viscous Dissipative Isotropic Cosmologies with Variable Gravitational and Cosmological Constants

We consider the evolution of a flat Friedmann-Robertson-Walker Universe, filled with a causal bulk viscous cosmological fluid, in the presence of variable gravitational and cosmological constants. The basic equation for the Hubble parameter, generalizing the evolution equation in the case of constant gravitational coupling and cosmological term, is derived, under the supplementary assumption that the total energy of the Universe is conserved. By assuming that the cosmological constant is proportional to the square of the Hubble parameter and a power law dependence of the bulk viscosity coefficient, temperature and relaxation time on the energy density of the cosmological fluid, two classes of exact solutions of the field equations are obtained. In the first class of solutions the Universe ends in an inflationary era, while in the second class of solutions the expansion of the Universe is non-inflationary for all times. In both models the cosmological "constant" is a decreasing function of time, while the gravitational "constant" increases in the early period of evolution of the Universe, tending in the large time limit to a constant value.Comment: 14 pages, 15 figure

The Influence of Gamma-rays on the Injury and Chromosomal Aberrations of Long Bean (Vigna sesquipedalis, Fruw.)

The effects of gamma-rays on three varieties of long bean (Vigna sesquipedalis, Fruw), namely Melaka, Local Black and Local Long were studied using Jive doses ranging from 10 to 50 kR. Both Chromosomal aberrations and characteristics related to physiological damage were used to study radiation sensitivity of the varieties. In general, gamma radiation did not affect % seed germination but caused a significant reduction in characteristics related to survival, growth and fertility. Percentage chromosomal aberrations also increased with increasing dose. As the measurement of seedling height is simple, quick and highly correlated with most characteristics studied, it could be a useful parameter in the study of radiation effects on long bean. Using a critenrion of approximately 30% reduction in seedling height or 50% lethality, it is suggested that doses ranging from 30 to 50 kR would be suitable for mutation induction in long bean

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at approximately equal rates. However, the subsequent 17,20 carbon–carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17α-hydroxypregnenlone (OHPREG) versus 17α-hydroxyprogesterone (OHPROG). Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme’s native preference for OHPREG. Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. In a series of resonance Raman experiments, it was observed that, in contrast with the case for the wild-type protein, in the mutant the 17α alcohol of OHPROG tends to form a H-bond with the proximal rather than terminal oxygen of the oxy–ferrous complex. When OHPREG was a substrate, the mutant enzyme was found to have a H-bonding interaction with the proximal oxygen that is substantially weaker than that of the wild type. These results demonstrate that a single-point mutation in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis

Dynamical simulation of transport in one-dimensional quantum wires

Transport of single-channel spinless interacting fermions (Luttinger liquid) through a barrier has been studied by numerically exact quantum Monte Carlo methods. A novel stochastic integration over the real-time paths allows for direct computation of nonequilibrium conductance and noise properties. We have examined the low-temperature scaling of the conductance in the crossover region between a very weak and an almost insulating barrier.Comment: REVTex, 4 pages, 2 uuencoded figures (submitted to Phys. Rev. Lett.

Effect of next-nearest neighbor coupling on the optical spectra in bilayer graphene

We investigate the dependence of the optical conductivity of bilayer graphene (BLG) on the intra- and inter-layer interactions using the most complete model to date. We show that the next nearest-neighbor intralayer coupling introduces new features in the low-energy spectrum that are highly sensitive to sample doping, changing significantly the ``universal'' conductance. Further, its interplay with interlayer couplings leads to an anisotropy in conductance in the ultraviolet range. We propose that experimental measurement of the optical conductivity of intrinsic and doped BLG will provide a good benchmark for the relative importance of intra- and inter-layer couplings at different doping levels.Comment: 5 pages, 5 figure

Strength and conditioning practices and perspectives of volleyball coaches and players

To the authors’ knowledge this is the first study to describe the strength and conditioning (S) practices and perspectives of volleyball coaches and players. In total, 30 volleyball coaches (mean age 34.47 ± 7.83 years and coaching experience 19.57 ± 8.28 years), and 30 volleyball players (mean age 22.03 ± 4.43 years and playing experience 10.43 ± 8.98 years) completed an online survey with six sections: (a) informed consent; (b) background information; (c) education, qualifications, and prescription; (d) views on S&C; (e) exercise selection and preferences; and (f) issues and improvements. Frequency analysis was used to report responses to fixed-response questions and thematic-analysis for open-ended questions. While only one participant possessed an S certification, S was deemed ‘important’ to ‘very important’ for volleyball skills, physical fitness, and injury parameters. However, due to a reported lack of expertise, there appeared to be a theoretical understanding to practice gap. Furthermore, the implementation of S was considerably hindered by a lack of time, facilities, and equipment. National sports associations, coaches, and players can use the information within this study to provide an understanding of the current practices and perspectives of S in volleyball. While also promoting future developments in S research and practice in volleyball

SRT1720 attenuates obesity and insulin resistance but not liver damage in the offspring due to maternal and postnatal high-fat diet consumption

© 2018 the American Physiological Society. Recent studies indicate that sirtuin-1 (SIRT1), an important metabolic sensor and regulator of life span, plays a mechanistic role in maternal obesity-induced programming of metabolic disorders in the offspring. In this study we investigate whether SIRT1 activation in early childhood can mitigate metabolic disorders due to maternal and postnatal high-fat feeding in mice. Male offspring born to chow-fed (MC) or high fat diet-fed dams (MHF) were weaned onto postnatal chow or high-fat diet and treated with SRT1720 (25 mg/kg ip every 2 days) or vehicle control for 6 wk and examined for metabolic disorders. MHF exacerbated offspring body weight and insulin resistance in the offspring exposed to postnatal HFD (OHF). These metabolic changes were associated with reduced hepatic lipid droplet accumulation but increased plasma levels of alanine aminotransferase (ALT), a marker of liver damage. SRT1720 significantly decreased offspring body weight, adiposity, glucose intolerance, and hyperleptinemia due to OHF and reversed hyperinsulinemia and adipocyte hypertrophy due to the additive effects of MHF. Although SRT1720 suppresses liver lipogenesis, inflammation, and oxidative stress markers, it also reduces antioxidants and increased liver collagen deposition in OHF offspring independent of MHF. Hepatic steatosis was attenuated only in MC/OHF offspring in association with elevated plasma ALT levels. The study suggests that postnatal SRT1720 administration can mitigate obesity and insulin resistance in the offspring due to maternal and postnatal HFD exposure. However, the possibility of liver toxicity needs to be further examined

The Ultraluminous X-ray Sources near the Center of M82

We report the identification of a recurrent ultraluminous X-ray source (ULX), a highly absorbed X-ray source (possibly a background AGN), and a young supernova remnant near the center of the starburst galaxy M82. From a series of Chandra observations taken from 1999 to 2005, we found that the transient ULX first appeared in 1999 October. The source turned off in 2000 January, but later reappeared and has been active since then. The X-ray luminosity of this source varies from below the detection level (~2.5e38 erg/s) to its active state in between ~7e39 erg/s and 1.3e40 erg/s (in the 0.5-10 keV energy band) and shows unusual spectral changes. The X-ray spectra of some Chandra observations are best fitted with an absorbed power-law model with photon index ranging from 1.3 to 1.7. These spectra are similar to those of Galactic black hole binary candidates seen in the low/hard state except that a very hard spectrum was seen in one of the observations. By comparing with near infrared images taken with the Hubble Space Telescope, the ULX is found to be located within a young star cluster. Radio imaging indicates that it is associated with a H II region. We suggest that the ULX is likely to be a > 100 solar mass intermediate-mass black hole in the low/hard state. In addition to the transient ULX, we also found a highly absorbed hard X-ray source which is likely to be an AGN and an ultraluminous X-ray emitting young supernova remnant which may be related to a 100-year old gamma-ray burst event, within 2 arcsec of the transient ULX.Comment: 9 pages, 8 figures. Accepted for publication in Ap

Crossover from Fermi liquid to Wigner molecule behavior in quantum dots

The crossover from weak to strong correlations in parabolic quantum dots at zero magnetic field is studied by numerically exact path-integral Monte Carlo simulations for up to eight electrons. By the use of a multilevel blocking algorithm, the simulations are carried out free of the fermion sign problem. We obtain a universal crossover only governed by the density parameter $r_s$. For $r_s>r_c$, the data are consistent with a Wigner molecule description, while for $r_s<r_c$, Fermi liquid behavior is recovered. The crossover value $r_c \approx 4$ is surprisingly small.Comment: 4 pages RevTeX, 3 figures, corrected Tabl

A general method to eliminate laboratory induced recombinants during massive, parallel sequencing of cDNA library.

Massive, parallel sequencing is a potent tool for dissecting the regulation of biological processes by revealing the dynamics of the cellular RNA profile under different conditions. Similarly, massive, parallel sequencing can be used to reveal the complexity of viral quasispecies that are often found in the RNA virus infected host. However, the production of cDNA libraries for next-generation sequencing (NGS) necessitates the reverse transcription of RNA into cDNA and the amplification of the cDNA template using PCR, which may introduce artefact in the form of phantom nucleic acids species that can bias the composition and interpretation of original RNA profiles