A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects

Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.This project has received funding from the European Unions' Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4E

Decoupled supercapacitive electrolyzer for membrane-free water splitting

Green hydrogen production via water splitting is vital for decarbonization of hard-to-abate industries. Its integration with renewable energy sources remains to be a challenge, due to the susceptibility to hazardous gas mixture during electrolysis. Here, we report a hybrid membrane-free cell based on earth-abundant materials for decoupled hydrogen production in either acidic or alkaline medium. The design combines the electrocatalytic reactions of an electrolyzer with a capacitive storage mechanism, leading to spatial/temporal separation of hydrogen and oxygen gases. An energy efficiency of 69% lower heating value (48 kWh/kg) at 10 mA/cm2 (5 cm–by–5 cm cell) was achieved using cobalt-iron phosphide bifunctional catalyst with 99% faradaic efficiency at 100 mA/cm2. Stable operation over 20 hours in alkaline medium shows no apparent electrode degradation. Moreover, the cell voltage breakdown reveals that substantial improvements can be achieved by tunning the activity of the bifunctional catalyst and improving the electrodes conductivity. The cell design offers increased flexibility and robustness for hydrogen production.E.A.T.-C. would like to thank the National Research and Development Agency of Chile (ANID) for the doctoral scholarship “Beca Chile” 2018-72190682. M.G.-R. and L.M.S.-M. would like to thank Campus Iberus for Erasmus+ KA103 scholarship and Facultad de Ciencias of University of Alicante for the internship scholarship. J.D. would like to acknowledge partial financing from Vinnova (diary no. 2021-02313) and Åforsk (ref. no. 21-105)

Aplicación Práctica de Métodos para Evaluar In-Situ el Rendimiento Instantáneo de Máquinas Frigoríficas de Compresión Mecánica

Libro de actas completo disponible en :http://repositorio.bib.upct.es:8080/dspace/handle/10317/4709Los equipos de aire acondicionado, bombas de calor y refrigeración suponen un elevado consumo de energía eléctrica en los países industrializados. Es frecuente que, en la práctica, estos equipos no estén operando con la eficiencia que debieran. De ahí la importancia de realizar inspecciones periódicas, que incluyan mediciones de los diferentes parámetros de operación de los equipos, destacando por su importancia la medición de su rendimiento (EER/COP). La medición precisa in-situ del EER/COP sobre una instalación frigorífica de compresión mecánica, fuera de un banco de ensayo de laboratorio, ha sido desde siempre una cuestión muy complicada, con muchas dificultades prácticas. Un punto crítico es la medición del caudal de fluido refrigerante. Si no se dispone de un caudalímetro instalado, que es la situación más habitual, hay que recurrir a mediciones indirectas. Hay varios métodos indirectos para estimar el caudal de refrigerante, que se pueden clasificar en los que se basan en: a) el rendimiento volumétrico del compresor, b) el rendimiento global del compresor, c) un balance de energía sobre el condensador y d) un balance de energía sobre el compresor. En este trabajo se ponen en práctica y analizan estos cuatro métodos sobre instalaciones frigoríficas existentes en el laboratorio docente del Departamento de Máquinas y Motores Térmicos de la Universidad de Málaga [1]. Para ello se utiliza un sistema de medición de bajo coste, basado en sensores ONSET [2]. El procesado y análisis de los datos se hace mediante el software Engineering Equation Solver [3]. Se discuten los resultados y dificultades encontradas en la aplicación de los diferentes métodos y se ofrecen recomendaciones a tener en cuenta para abordar instalaciones más complejas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech