Analysis of Heat Transfers inside Counterflow Plate Heat Exchanger Augmented by an Auxiliary Fluid Flow

Enhancement of heat transfers in counterflow plate heat exchanger due to presence of an intermediate auxiliary fluid flow is investigated. The intermediate auxiliary channel is supported by transverse conducting pins. The momentum and energy equations for the primary fluids are solved numerically and validated against a derived approximate analytical solution. A parametric study including the effect of the various plate heat exchanger, and auxiliary channel dimensionless parameters is conducted. Different enhancement performance indicators are computed. The various trends of parameters that can better enhance heat transfer rates above those for the conventional plate heat exchanger are identified. Large enhancement factors are obtained under fully developed flow conditions. The maximum enhancement factors can be increased by above 8.0- and 5.0-fold for the step and exponential distributions of the pins, respectively. Finally, counterflow plate heat exchangers with auxiliary fluid flows are recommended over the typical ones if these flows can be provided with the least cost

Mathematical and Numerical Analysis of Heat Transfer Enhancement by Distribution of Suction Flows inside Permeable Tubes

Heat transfer enhancement in permeable tubes subjected to transverse suction flow is investigated in this work. Both momentum and energy equations are solved analytically and numerically. Both solutions based on negligible entry regions are well matched. Two different suction velocity distributions are considered. A parametric study including the influence of the average suction velocity and the suction velocity profile is conducted for various Peclet numbers. It is found that enhancement of heat transfer over that in impermeable tubes is only possible with large Peclet numbers. This enhancement increases as suction velocities towards the tube outlet increase and as those towards the tube inlet decrease simultaneously. The identified enhancement mechanisms are expanding the entry regions, increasing the transverse advection, and increasing the downstream excess temperatures under same transverse advection. The average suction velocity that produces maximum enhancement increases as the Peclet number increases until it reaches asymptotically its uppermost value at large Peclet numbers. The maximum reported enhancement ratios for the exponential and linear suction velocity distributions are 17.62-fold and 14.67-fold above those for impermeable tubes, respectively. This work demonstrates that significant heat transfer enhancement is attainable when the suction flow inside the permeable tubes is distributed properly

Bridging Serious Games and Participatory Design

Participatory design (PD) has become widely popular within the interaction design community, but to date has had little influence within serious game design processes. We argue that serious game design complicates the notion of involving users as co-designers, as serious game designers must be fluent with both domain content and game design. In this paper, we share our experiences of using PD during the design process of a serious game. We present observations stemming from attempts to apply the existing PD methods of brainstorming and storyboarding. Reflecting on the shortcomings of these methods, we go on to propose a novel PD method that leverages two fundamental qualities of serious games–domain expertise and procedurality–to scaffold players’ existing knowledge and make co-design of serious games an attainable goal

Mathematical Extrapolating of Highly Efficient Fin Systems

Different high-performance fins are mathematically analyzed in this work. Initially, three types are considered: (i) exponential, (ii) parabolic, and (iii) triangular fins. Analytical solutions are obtained. Accordingly, the effective thermal efficiency and the effective volumetric heat dissipation rate are calculated. The analytical results were validated against numerical solutions. It is found that the triangular fin has the maximum effective thermal length. In addition, the exponential pin fin is found to have the largest effective thermal efficiency. However, the effective efficiency for the straight one is the maximum when its effective thermal length based on profile area is greater than 1.4. Furthermore, the exponential straight fin is found to have effective volumetric heat dissipation that can be 440% and 580% above the parabolic and triangular straight fins, respectively. In contrast, the exponential pin fin is found to possess effective volumetric heat dissipation that can be 120% and 132% above the parabolic and triangular pin fins, respectively. Finally, new high performance fins are mathematically generated that can have effective volumetric heat dissipation of 24% and 12% above those of exponential pin and straight fins, respectively

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation

Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is able to self-assemble through hydrogen bonding and π-π stacking interactions, resulting in an addressable polymer network with a relatively low processing temperature. The mechanical properties of the SPU demonstrated the material was self-supporting, stiff, yet flexible thus making it suitable for hot-melt extrusion processing, inclusive of related 3D printing approaches. Cell-based toxicity assays revealed the SPU to be non-toxic and therefore a viable candidate as a biocompatible polymer for implant applications. To this end, the SPU was formulated with paracetamol (16 %w/w) and 4 wt% or 8 wt% poly(ethylene glycol) (PEG) as an excipient and hot melt extruded at 100 °C to afford a 3D printed prototype implant to explore the extended drug release required for an implant and the potential manipulation of the release profile. Furthermore, rheological, infra-red spectroscopy, powder X-ray diffraction and scanning electron microscopy studies revealed the chemical and physical properties and compatibility of the formulation components. Successful release of paracetamol was achieved from in vitro dissolution studies and it was predicted that the drug would be released over a period of up to 8.5 months with hydrophilic PEG being able to influence the release rate. This extended release time is consistent with applications of this novel dynamic polymer as a drug eluting implant matrix

The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption

Metastasis accounts for most deaths from breast cancer, driving the need for new therapeutics that can impede disease progression. Rationally designed peptides that take advantage of cancer-specific differences in cellular physiology are an emerging technology that offer promise as a treatment for metastatic breast cancer. We developed CT20p, a hydrophobic peptide based on the C terminus of Bax that exhibits similarities with antimicrobial peptides, and previously reported that CT20p has unique cytotoxic actions independent of full-length Bax. In this study, we identified the intracellular actions of CT20p which precede cancer cell-specific detachment and death. Previously, we found that CT20p migrated in the heavy membrane fractions of cancer cell lysates. Here, using MDA-MB-231 breast cancer cells, we demonstrated that CT20p localizes to the mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. As a result, the distribution and movement of mitochondria in CT20p-treated MDA-MB-231 cells was markedly impaired, particularly in cell protrusions. In contrast, CT20p did not associate with the mitochondria of normal breast epithelial MCF-10A cells, causing little change in the mitochondrial membrane potential, morphology or localization. In MDA-MB-231 cells, CT20p triggered cell detachment that was preceded by decreased levels of alpha 5 beta 1 integrins and reduced F-actin polymerization. Using folate-targeted nanoparticles to encapsulate and deliver CT20p to murine tumors, we achieved significant tumor regression within days of peptide treatment. These results suggest that CT20p has application in the treatment of metastatic disease as a cancer-specific therapeutic peptide that perturbs mitochondrial morphology and movement ultimately culminating in disruption of the actin cytoskeleton, cell detachment, and loss of cell viability

Influence of Annealing Temperature on Structural, Electrical, and Magnetic Properties of Nd0.7Ca0.3MnO3

In this paper, we investigated the effect of annealing temperature on the electrical and magnetic properties of polycrystalline Nd0.7Ca0.3MnO3 synthesized using the well-known solid-state reaction technique. After the formation of the required Perovskite crystal structure phase, another annealing treatment has been done. The selected annealing temperatures are 700, 800, and 900°C for 12 hours. Structural refinement of the X-ray diffraction patterns showed the formation of a single orthorhombic crystal structure phase the of P b n m space group in Nd0.7Ca0.3MnO3 without any impurity peaks. From magneto-resistance measurements, we found that NCMO samples have high-colossal magnetoresistance (CMR). Moreover, the under-investigated NCMO samples showed a high power factor. The resistivity data in the insulating region (T \u3eTMI) were analyzed by considering, the Mott-variable range hopping model. The phase transition temperature showed dependence on the grain size, where Curie temperature (TC) increases with an increase in the grain size

Initial Study for Cost-Effectiveness of Joint/Crack Sealing

The sealing and resealing of joints and cracks in PCC, HMA, and composite pavements is assumed to be an important component of pavement maintenance. Recently this practice has been challenged by research indicating that sealing may not be cost-effective. The Indiana Department of Transportation currently spends approximately four million dollars annually to perform joint/crack sealing. The primary objective of the research presented in this report is to investigate the costeffectiveness of joint/crack sealing in relation to pavement performance. The results of a mail survey showed that most states, including Indiana, do not have quantitative justification for sealing policies, nor do they know the cost-effectiveness of the operations. Based on the experimental design for this research, nineteen test sites were selected in Indiana, each site having one sealed section and one unsealed section. Collected data including falling weight deflectometer measurements, pavement roughness, visual condition surveys, and core samples were used to evaluate the pavement performance between sealed and unsealed sections. A three-dimensional finite element pavement model was developed to evaluate the test location effect on the load transfer measurements. The temperature effect was evaluated by statistical analyses and a temperature correction factor for deflections on asphalt pavement is provided. A statistical model was developed to compare the pavement performance between sealed and unsealed sections for three pavement types, PCC, HMA and composite. The results indicated that there appears to be no significant differences between the performance of sealed and unsealed sections regardless of pavement type, drainage condition and road classification

Breakup of Turbulent and Non-Turbulent Liquid jets in Gaseous Crossflows

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76872/1/AIAA-2006-1517-140.pd