KESESUAIAN PENGGUNAAN LAHAN PERMUKIMAN DENGAN RENCANA TATA RUANG WILAYAH DI PESISIR PULAU WANGI-WANGI KABUPATEN WAKATOBI

Bajo Mola Raya tribe settlement on Wangi-wangi Island, Wakatobi Regency is improving development that is not in accordance with spatial aspects. The research aimed to analyze the development of the existing residential land use in Mola Raya Area with the Regional Spatial Plan, to identify the factors causing the development of the residential land use in Mola Raya Area with the Regional Spatial Plan of Wakatobi Regency comprising the external and internal factors. The external factors included (a) the population growth; (b) community economy; and (c) community socio-culture, whereas the internal factors comprised: (d) supervision; (e) licensing; (f) control. The research used the map overlay technique. The analysis started from the results of digitalization on the screen of the google earth image in 2018. Then the overlay technique was then carried out using the residential area spatial pattern plan map of Wangi-Wangi Island, the descriptive method was used from FFA analysis result, interview, and Focus Group Discussion (FGD). The research result indicates that the development of the residential area which is not suitable with the Regional Spatial Plan is at Mola Utara Village with the congruity of 76,53%, Mola Nelayan Bakti Village with the congruity 76,87% on the residential area spatial pattern plan of Wangi-Wangi Island. Then the most influential factors on the residential development Bajo Mola Raya ethnic group indicate the factors of the population growth, community economy, and community culture. The internal factors indicate the lack of supervision, licensing, control from the regional government

Does true Gleason pattern 3 merit its cancer descriptor?

Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted

Environmental Geophysics at Kings Creek Disposal Site and 30th Street Landfill, Aberdeen Proving Ground, Maryland

Geophysical studies on the Bush River Peninsula in the Edgewood Area of Aberdeen Proving Ground, Maryland, delineate landfill areas and provide diagnostic signatures of the hydrogeologic framework and possible contaminant pathways. These studies indicate that, during the Pleistocene Epoch, alternating stands of high and low seal levels resulted in a complex pattern of shallow channel-fill deposits in the Kings Creek area. Ground-penetrating radar studies reveal a paleochannel greater than 50 ft deep, with a thalweg trending offshore in a southwest direction into Kings Creek. Onshore, the ground-penetrating radar data indicate a 35-ft-deep branch to the main channel, trending to the north-northwest directly beneath the 30th Street Landfill. Other branches are suspected to meet the offshore paleochannel in the wetlands south and east of the 30th Street Landfill. This paleochannel depositional system is environmentally significant because it may control the shallow groundwater flow regime beneath the site. Electromagnetic surveys have delineated the pre-fill lowland area currently occupied by the 30th Street Landfill. Magnetic and conductive anomalies outline surficial and buried debris throughout the study area. On the basis of geophysical data, large-scale dumping has not occurred north of the Kings Creek Disposal Site or east of the 30th Street Landfill

Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization

The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcoma cell line, UTOS-1, from a typical osteoblastic OS of an 18-year-old man. Cultured UTOS-1 cells are spindle-shaped, and have been maintained in vitro for over 50 passages in more than 2 years. Xenografted UTOS-1 cells exhibit features typical of OS, such as production of osteoid or immature bone matrix, and proliferation potency in vivo. UTOS-1 also exhibit morphological and immunohistochemical characteristics typical of osteoblastic OS. Chromosomal analysis by G-band show 73~85 chromosomes with complicated translocations. Array CGH show frequent gains at locus DAB2 at chromosome 5q13, CCND2 at 12p13, MDM2 at 12q14.3-q15, FLI and TOP3A at 17p11.2-p12 and OCRL1 at Xq25, and show frequent losses at HTR1B at 6q13, D6S268 at 6q16.3-q21, SHGC17327 at 18ptel, and STK6 at 20q13.2-q13.3. The UTOS-1 cell line may prove useful for biologic and molecular pathogenetic investigations of human OS

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Assessment of the hydrogeologic framework beneath Campbell Army Airfield, Fort Campbell, Kentucky, using geophysical technologies

Geophysical data were combined with published reports to construct a model of the hydrogeologic framework at Campbell Army Airfield near the Kentucky- Tennessee state line. Electrical resistivity, seismic refraction, and electromagnetic methods provide information on thickness and character of layers in the overburden, bedrock depth, and identified areas where pre-airfield drainage and topography have been altered. The thickness of the residuum overlying bedrock has been interpreted to range from 16 to 150 ft (4.9 to 45.7 m) on the basis of seismic refraction surveys and vertical electrical soundings. The accuracy of these geophysical methods has been verified by performing calibration soundings at four wells drilled into bedrock. Water-bearing zones above the regional, fractured and karstified aquifer in the St. Louis limestone are discontinuous and may be influenced by the topography and the degree of weathering of the underlying bedrock. The vertical hydraulic transmissivity may be increased over bedrock highs, resulting in locally faster drainage of the clay-rich residual soil. In addition, the relatively higher porosity epikarst zone at the residuum-bedrock interface, and heavily fractured sections within the bedrock may act as a conduit for the transmission and storage of LNAPL contaminant JP-8 (jet fuel) migrating through the overburden. Resistivity values computed from data collected over seismically defined bedrock highs are consistent with well-drained soils overlying bedrock. These areas may ultimately prove useful in identifying zones where JP-8 migration and storage is most likely