Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report

<p>Abstract</p> <p>Introduction</p> <p>A tumor metastasizing to another malignancy is an uncommon phenomenon. Since it was first described in 1902, there have been fewer than 200 cases reported in the literature, with lung cancer metastasizing to renal cell carcinoma being the most frequently described pattern. Here we report a case of a solitary fibrous tumor of the lung acting as the recipient for a renal cell carcinoma. To our knowledge, this is the first reported case of such a combination and the second case involving a solitary fibrous tumor.</p> <p>Case presentation</p> <p>A 58-year-old Caucasian man who developed a persistent dry cough presented to our hospital. Imaging studies revealed a large pleural-based mass in the left lung. A biopsy of the mass showed a spindle-cell lesion consistent with a solitary fibrous tumor. The patient underwent surgical excision of the 13 cm mass. The pathological examination confirmed the diagnosis of a solitary fibrous tumor but also demonstrated discrete foci of metastatic renal cell carcinoma. Until that point, a primary renal cell carcinoma tissue diagnosis had not been made and the initial radiological work-up was inconclusive.</p> <p>Conclusion</p> <p>Awareness of the unusual phenomenon of tumor-to-tumor metastasis is important for practicing surgical pathologists, particularly in the evaluation of a mass lesion showing bimodal histology. This case also highlights the importance of careful examination of surgical specimens, as minute and unusual findings can direct patient care.</p

Targeted Deletion of Kcne2 Causes Gastritis Cystica Profunda and Gastric Neoplasia

Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising the KCNQ1 α subunit and the KCNE2 β subunit provide a K+ efflux current to facilitate gastric acid secretion by the apical H+K+ATPase. Accordingly, genetic deletion of murine Kcnq1 or Kcne2 impairs gastric acid secretion. Other evidence has suggested a role for KCNE2 in human gastric cancer cell proliferation, independent of its role in gastric acidification. Here, we demonstrate that 1-year-old Kcne2−/− mice in a pathogen-free environment all exhibit a severe gastric preneoplastic phenotype comprising gastritis cystica profunda, 6-fold increased stomach mass, increased Ki67 and nuclear Cyclin D1 expression, and TFF2- and cytokeratin 7-expressing metaplasia. Some Kcne2−/−mice also exhibited pyloric polypoid adenomas extending into the duodenum, and neoplastic invasion of thin walled vessels in the sub-mucosa. Finally, analysis of human gastric cancer tissue indicated reduced parietal cell KCNE2 expression. Together with previous findings, the results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia

An unusual case of Behçet's disease presenting with bilateral internal carotid artery occlusion

WOS: 000177702900030PubMed ID: 1218517

Total oxidant and antioxidant activities in milk with various somatic cell count intervals during discrete cow and buffalo lactation periods

YAZICI, Ebubekir/0000-0002-1219-4370; KABAKCI, Ruhi/0000-0001-9131-0933WOS: 000426365000012This study first investigated the total oxidant and antioxidant capacity (TOC and TAC, respectively) in cow and buffalo milk, with various somatic cell count (SCC) levels, having the same lactation numbers(LN). Second, it determined whether there is an association between the TAC and TOC and the lactation number, for the same SCC level. Quarter milk samples, collected from Holstein cows and Anatolian buffaloes, were separated into SCC levels of = 1x10(6) cells mL(-1) for cow milk, and = 1x10(6) cells mL(-1), for buffalo milk. Next, each group was subdivided, according to the lactation number (cows: 1-2nd, 3-4th, 5-6th, buffaloes: 1-4th, 5-8th, 9-12th), and TOC and TAC of the milk were measured. For the same lactation numbers, TOC increased in the cow and buffalo groups with an SCCV >= 1x10(6) cells mL(-1) (p 5x10(5)cells mL(-1). In buffalo milk, TAC decreased in parallel with the increased SCC. Among the same SCC groups, TOC and TAC were not affected by the lactation number, in cow and buffalo milk. An increased SCC caused an increased TOC and decreased TAC level, for the same lactation number. No relation existed among TOC, TAC and lactation number, for the same SCC level. SCC may be used as an indicator of TOC and TAC in cow and buffalo milk.Kirikkale UniversityKirikkale University [2014/120]This study was supported by the Kirikkale University Scientific Research Project Coordination Unit: 2014/120

Total oxidant and antioxidant activities in milk with various somatic cell count intervals during discrete cow and buffalo lactation periods (conferenceObject)

KABAKCI, Ruhi/0000-0001-9131-0933WOS: 000485252000275

Neurotoxicity with single dose intrathecal midazolam administration

WOS: 000233719400003PubMed ID: 16318660Background and objective: The aim of study was to investigate the electron microscopic changes in the medulla of the spinal cord that occur with intrathecal midazolam administration. Methods: Twenty-eight albino rabbits of New Zealand type were randomized into two groups. Following anaesthesia, 16 rabbits were given 300 mu g of midazolam (Group M) and 12 rabbits were given 0.3 mL of normal saline solution (Group O) intrathecally. Eight rabbits from Group M (Group M1) and 6 rabbits from Group C (Group C1) were sacrificed 24 h after the anaesthesia and 8 rabbits from Group M (Group M2) and 6 rabbits from Group C (Group C2) were sacrificed 6 days after the anaesthesia. The lumbosacral portion was removed by laminectomy and thin sections were examined microscopically. Results: Severe separation in myelin lamella of the large axons, honeycomb appearance, slight separation in myelin lamella of small to moderately large axons, degenerate vacuoles in the cytoplasm and nuclear membrane irregularity were observed in neurons of Groups M1 and M2. Myelin lamella and nuclear membranes were found to be regular, vacuoles and oedema were observed in the neurons in the Groups C I and C2. Conclusion: Midazolam administered at single dose by the intrathecal route may have neurotoxic effects on the neurons and myelinated axons at 24 h and 6 days following administration