Delivering Quality Early Learning In Low-Resource Settings: Progress And Challenges In Ethiopia

The potential of high quality early childhood care and education ECCE programmes to deliver positive outcomes for children and society is well recognised. But delivering on this potential presents huge challenges, especially in low and middle income countries. This final working paper in the Transitions in Early Childhood series focusses on Ethiopia. While in many respects Ethiopia is a success story of Education For All, in terms of increased enrolments in primary education, the early years of schooling is faced with numerous access and quality challenges. This working paper reviews the government of Ethiopia's 2010 policy framework for ECCE and highlights these different challenges in rural and urban areas of Ethiopia, drawing on survey and qualitative research data collected as part of Young Lives longitudinal research

Networking erythropoiesis

Recent findings and technological advances provide insight into how a few transcription factors work together in complex ways to orchestrate red blood cell differentiation

Stage-Specific Effects ofSonic HedgehogExpression in the Epidermis

AbstractSonic hedgehog (Shh) is expressed in the ectoderm of the forming hair follicle and feather bud during normal development. However, inappropriate activation of the Shh signal transduction cascade in human epidermis can cause basal cell carcinoma. Here we show that during normal development of avian skin, Shh is first expressed only after the responsiveness to this protein has been suppressed in most of the surrounding ectodermal cells. Forced expression of Shh in avian skin prior to this time causes a disorganized ectodermal proliferation. However, as skin begins to differentiate, the forced expression of Shh causes feather bud formation. Subsequently, expression of Shh in interfollicular epidermis has little or no morphological effect. Restricted responsiveness to Shh in developing skin has functional consequences for morphogenesis and may have important implications for cutaneous pathologies as well

'Just another vial…': a qualitative study to explore the acceptability and feasibility of routine blood-borne virus testing in an emergency department setting in the UK.

OBJECTIVES: Increased test uptake for HIV and viral hepatitis is fast becoming a health priority at both national and global levels. Late diagnosis of these infections remains a critical public health concern in the UK. Recommendations have been issued to expand blood-borne virus (BBV) testing in alternative settings. Emergency departments (EDs) offer a potentially important point of testing. This paper presents findings from a qualitative study which aimed to explore the acceptability and feasibility of a routine opt-out combined BBV testing intervention implemented at an inner London ED. METHODS: We conducted 22 semistructured interviews with patients and service providers in the ED over a 4-month period during the intervention pilot. A grounded analytical approach was employed to conduct thematic analysis of qualitative study data. RESULTS: Core interrelating thematic areas, identified and analytically developed in relation to test intervention implementation and experience, included the following: the remaking of routine test procedure; notions of responsibility in relation to status knowledge and test engagement; the opportunity and constraints of the ED as a site for testing; and the renegotiation of testing cultures within and beyond the clinic space. CONCLUSION: Study findings demonstrate how relational and spatial dynamics specific to the ED setting shape test meaning and engagement. We found acceptability of the test practice was articulated through narratives of situated responsibility, with the value of the test offset by perceptions of health need and justification of the test expense. Participant accounts indicate that the nontargeted approach of the test affords a productive disruption to 'at-risk' identities, yet they also reveal limits to the test intervention's 'normalising' effect. Evaluation of the intervention must attend to the situated dynamics of the test practice if opportunities of an opt-out BBV test procedure are to be fully realised. Findings also highlight the critical need to further evaluate post-test intervention practices and experiences

Ozone-depleting substances (ODSs) and related chemicals

The amended and adjusted Montreal Protocol continues to be successful at reducing emissions and atmospheric abundances of most controlled ozone-depleting substances (ODSs).Global Ozone Research and Monitoring Projec

SCIENTIFIC CONTRIBUTION OF PROFESSOR P. V. NIKOLSKY TO THE DEVELOPMENT OF DERMATOLOGY AND VENEROLOGY IN RUSSIA (DELICATED TO THE 150TH ANNIVERSARY OF HIS BIRTH)

The article contains some biographical information about professor P. V. Nikolsky, which reflects scientific and practical contribution to the development of native Dermatology and Venereology, to the organization of the Imperial Nikolaev’s University (Saratov) foundation and the becoming of dermatovenerological services in the USSR

Semi-automated dialogue act classification for situated social agents in games

As a step toward simulating dynamic dialogue between agents and humans in virtual environments, we describe learning a model of social behavior composed of interleaved utterances and physical actions. In our model, utterances are abstracted as {speech act, propositional content, referent} triples. After training a classifier on 100 gameplay logs from The Restaurant Game annotated with dialogue act triples, we have automatically classified utterances in an additional 5,000 logs. A quantitative evaluation of statistical models learned from the gameplay logs demonstrates that semi-automatically classified dialogue acts yield significantly more predictive power than automatically clustered utterances, and serve as a better common currency for modeling interleaved actions and utterances

Community health survey of Oukasie, 1987

A series of surveys were conducted at the request of the community of Oukasie to determine certain public health information in the township, a peri-urban black community. This article describes two of these surveys. The first, a census and partial demographic survey, showed that the total black population was around 6300 with a mean household occupancy of 4,1. Some of the estimated vital statistics calculated were an infant mortality rate of 36,6/1 000, a crude birth rate of 28,0/1 000, a crude death rate of 6,5/1000, and a general fertility rate of 99,3/1 000. The second survey into the nutritional and immunisation status of children aged under 5 years showed that 20% of children were underweight and nearly half were incompletely immunised at 1 year of age. These studies, involving local community and student volunteers, were rapidly and inexpensively done and provide basic public health Information