Patterns of neonatal hypoxic–ischaemic brain injury

Enormous progress has been made in assessing the neonatal brain, using magnetic resonance imaging (MRI). In this review, we will describe the use of MRI and proton magnetic resonance spectroscopy in detecting different patterns of brain injury in (full-term) human neonates following hypoxic–ischaemic brain injury and indicate the relevance of these findings in predicting neurodevelopmental outcome

Management of the Depressed Newborn; to Cool or Not to Cool

Hypoxic-ischaemic encephalopathy (HIE) is arguably the most important neurologic condition to affect term newborns with significant adverse sequelae including death and disability in survivors. Since mild therapeutic hypothermia has been shown to improve outcomes, the field has become highly energized with optimism and new research. Using a case study, the challenges of selecting babies for neuroprotection are explored. This is followed by a look at what is on the horizon including cooling outside of standard criteria, mild HIE and novel biomarkers

Deficits of brainstem and spinal cord functions after neonatal hypoxia–ischemia in mice

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