Computational analysis of the behavior of atmospheric pollution due to demographic, structural factors, vehicular flow and commerce activities

According to the latest assessments made by the world health organization (WHO2016), the atmospheric pollution (air), has become one of the main causes of morbidity and mortality in the world, with a steep growth of respiratory diseases, increase in lung cancer, ocular complications, and dermis diseases [1,2,3]. Currently, there are governments which still underestimate investments in environmental care, turning their countries into only consumers and predators of the ecosystem [1,2,3]. Worldwide, several cities have been implementing different regional strategies to decrease environmental pollution, however, these actions have not been effective enough and significant indices of contamination and emergency declarations persist [1,2,3]. Medellín is one of the cities most affected by polluting gases in Latin America due to the high growth of construction sector, high vehicular flow, increase in commerce, besides a little assertive planting trees system, among other reasons [1,2,3]. With the purpose of providing new researching elements which benefit the improvement of air quality in the cities of the world, it is pretended to mathematically model and computationally implement the behavior of the flow of air, e.g., in zones in the city of Medellín to determine the extent of pollution by tightness, impact of current architectural designs, vehicular transport, high commerce flow, and confinement in the public transport system. The simulations allowed to identify spotlights of particulate tightness caused by architectural designs of the city which do not benefit air flow. Also, recirculating gases were observed in different zones of the city. This research can offer greater knowledge around the incidence of pollution generated by structures and architecture. Likewise, these studies can contribute to a better urban, structural and ecological reordering in cities, the implementation of an assertive arborization system, and the possibility to orientate effective strategies over cleaning (purification) and contaminant extracting systems

A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI

BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality. Based on the volume of the published literature addressing this condition, reporting both supporting as well as conflicting molecular evidence, it is apparent that a comprehensive analysis strategy is required to understand and fully delineate molecular events and pathways which can be used to describe disease induction and progression as well as lead to a more targeted approach in intervention therapies.<p></p> RESULTS: We used a Systems Biology approach coupled with a de-novo high-resolution proteomic analysis of kidney cortex samples from a mouse model of folic acid-induced AKI (12 animals in total) and show comprehensive mapping of signalling cascades, gene activation events and metabolite interference by mapping high-resolution proteomic datasets onto a de-novo hypothesis-free dataspace. The findings support the involvement of the glutamatergic signalling system in AKI, induced by over-activation of the N-methyl-D-aspartate (NMDA)-receptor leading to apoptosis and necrosis by Ca2+-influx, calpain and caspase activation, and co-occurring reactive oxygen species (ROS) production to DNA fragmentation and NAD-rundown. The specific over-activation of the NMDA receptor may be triggered by the p53-induced protein kinase Dapk1, which is a known non-reversible cell death inducer in a neurological context. The pathway mapping is consistent with the involvement of the Renin-Angiotensin Aldosterone System (RAAS), corticoid and TNFalpha signalling, leading to ROS production and gene activation through NFkappaB, PPARgamma, SMAD and HIF1alpha trans-activation, as well as p53 signalling cascade activation. Key elements of the RAAS-glutamatergic axis were assembled as a novel hypothetical pathway and validated by immunohistochemistry.<p></p> CONCLUSIONS: This study shows to our knowledge for the first time in a molecular signal transduction pathway map how AKI is induced, progresses through specific signalling cascades that may lead to end-effects such as apoptosis and necrosis by uncoupling of the NMDA receptor. Our results can potentially pave the way for a targeted pharmacological intervention in disease progression or induction.<p></p&gt

Temperature dependence of surface stress across an order-disorder transition: p(1x2)O/W(110)

Strain relaxations of a p(1x2) ordered oxygen layer on W(110) are measured as a function of temperature across the disordering transition using low-energy electron diffraction. The measured strains approach values of 0.027 in the [1-10] and -0.053 in the [001] direction. On the basis of the measured strain relaxations, we give quantitative information on temperature-dependent surface stress using the results of ab initio calculations. From the surface formation energy for different strains, determined by first-principles calculations, we estimate that surface stress changes from -1.1 for the ordered phase to -0.2N/m for the disordered one along [1-10], and from 5.1 to 3.4 N/m along [001]. Moreover, our observation that the strains scale inversely with domain size confirms that the strain relaxation takes place at the domain boundaries.Comment: 8 pages, 5 figure

AGILITY EXERCISE PROGRAM FOR SCHOOL EMERGENCY STUDENT-RESPONDERS’ TEAM

This study assessed the effectiveness of the four-week agility exercise program for emergency student-responders. It employed a quasi-experimental with a single group where pretest and posttest results are paired. Twenty-nine participated in the study grouped to 19 male and 10 female student-responders. Hexagon agility test was used to assess the agility level of the research participants before (pretest) and after (posttest) participating in the exercise program. The student-participants underwent a 4-week agility exercise program to develop their agility using plyometric exercises. Findings revealed a significant difference between the pre-test and post-test agility levels among the research participants. These findings led to the conclusion that the agility exercise program improved the agility level of emergency student-responders and is recommended for the implementation for all members’ emergency responding team and to the students in general.  Article visualizations

A new Phoenician location discovered in the Bay of Cádiz: El Cerro del Castillo, Chiclana

Los recientes hallazgos arqueológicos en el casco antiguo de Chiclana han aportado nuevos datos sobre la colonización fenicia en la bahía de Cádiz. El importante descubrimiento de un recinto fortificado, correspondiente al primer momento de la misma y de la creación de factorías en contexto peninsular, supone un avance significativo para el conocimiento de la organización territorial del momento y una nueva fuente de datos para la investigación arqueológica e histórica actual. El hecho de que ahora sean tres los enclaves fenicios existentes en la bahía: Cádiz, Chiclana y Doña Blanca (El Puerto de Santa María), permite una mejor interpretación de los textos griegos, que denominaban a esta zona “Gadeira” y al templo de “Melkart”, en Chiclana “puerta de Occidente”.The recent archeological findings in old uptown Chiclana have contributed new data about the Phoenician settlements in the Cádiz Bay. The important discovery of a fortified enclosure, in snchrony with the first Phoenician colonization and also with the creation of factories within the peninsular context, constitutes a significant advance in the present archaeological and historiacal research. The fact that we now have there Phoenician settlements in the Bay area, Cádiz, Chiclana and Doña Blanca, allows us a more accurate interpretation of the Greek text wich refered to this location as Gadeira and to the Melkart temple as the “gate to the West”

Element specific characterization of heterogeneous magnetism in (Ga,Fe)N films

We employ x-ray spectroscopy to characterize the distribution and magnetism of particular alloy constituents in (Ga,Fe)N films grown by metal organic vapor phase epitaxy. Furthermore, photoelectron microscopy gives direct evidence for the aggregation of Fe ions, leading to the formation of Fe-rich nanoregions adjacent to the samples surface. A sizable x-ray magnetic circular dichroism (XMCD) signal at the Fe L-edges in remanence and at moderate magnetic fields at 300 K links the high temperature ferromagnetism with the Fe(3d) states. The XMCD response at the N K-edge highlights that the N(2p) states carry considerable spin polarization. We conclude that FeN{\delta} nanocrystals, with \delta > 0.25, stabilize the ferromagnetic response of the films.Comment: 4 pages, 3 figures, 1 tabl

Strain relaxation in small adsorbate islands: O on W(110)

The stress-induced lattice changes in a p(1x2) ordered oxygen layer on W(110) are measured by low-energy electron diffraction. We have observed that small oxygen islands show a mismatch with the underlying lattice. Our results indicate that along [1-10] the average mismatch scales inversely with the island size as 1/L for all oxygen coverages up to 0.5 ML, while along [001] it is significant only for the smallest oxygen islands and scales as a higher power of the inverse island size. The behaviour along [1-10] is described by a one-dimensional finite-size Frenkel-Kontorova model. Using this model, together with calculated force constants, we make a quantitative estimate for the change of surface-stress upon oxygen adsorption. The result is consistent with our ab-initio calculations, which give a relative compressive stress of -4.72 N/m along [1-10] and a minute relative tensile stress of 0.15 N/m along [001]. The scaling along [001] is qualitatively explained as an effect induced by the lattice relaxation in the [1-10] direction.Comment: 22 pages, 5 figure

Electrostatic internal energy using the method of images

For several configurations of charges in the presence of conductors, the method of images permits us to obtain some observables associated with such a configuration by replacing the conductors with some image charges. However, simple inspection shows that the potential energy associated with both systems does not coincide. Nevertheless, it can be shown that for a system of a grounded or neutral conductor and a distribution of charges outside, the external potential energy associated with the real charge distribution embedded in the field generated by the set of image charges is twice the value of the internal potential energy associated with the original system. This assertion is valid for any size and shape of the conductor, and regardless of the configuration of images required. In addition, even in the case in which the conductor is not grounded nor neutral, it is still possible to calculate the internal potential energy of the original configuration through the method of images. These results show that the method of images could also be useful for calculations of the internal potential energy of the original system.Comment: 5 pages, 3 figures. New discussions added. Minor change