124 research outputs found
Focused ion beam creation and templating of InAs and InAs/InP nanospikes
Ion beam irradiation has been examined as a method for creating nanoscale semiconductor pillar and cone structures, but has the drawback of inaccurate nanostructure placement. We report on a method for creating and templating nanoscale InAs spikes by focused ion beam (FIB) irradiation of both homoepitaxial InAs films and heteroepitaxial InAs on InP substrates. These 'nanospikes' are created as In droplets, formed due to FIB irradiation, act as etch masks for the underlying InAs. By pre-patterning the InAs to influence In droplet movement, nanospike locations on homoepitaxial InAs may be controlled with limited accuracy. Creating nanospikes using an InAs/InP heterostructure provides an additional measure of control over where the spikes form because nanospikes will not form on exposed regions of InP. This effect may be exploited to accurately control nanospike placement by pre-patterning an InAs/InP heterostructure to control the location of the InAs/InP interface. Using this heterostructure templating method it is possible to accurately place nanospikes into regular arrays that may be useful for a variety of applications.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90790/1/0957-4484_22_35_355302.pd
Elastically Induced Coexistence of Surface Reconstructions
Scanning tunneling microscopy of Sb-capped GaAs shows the coexistence of different surface reconstructions. The majority of the surface consists of an α2(2×4) reconstruction typically observed for GaAs(001) surfaces. At step edges, an α(4×3) reconstruction, common for GaSb(001), is observed. We argue that strain couples the surface reconstruction to the film morphology. Density functional theory calculations show that the (2×4) reconstruction is stabilized in GaSb films when the lattice parameter is constrained to that of GaAs, as happens in the middle of a terrace, while the (4×3) reconstruction is stabilized when the lattice parameter is allowed to relax toward that of GaSb at step edges. This result confirms the importance of elastic relaxation in the coexistence of surface reconstructions
Lateral composition modulation in short period superlattices: The role of growth mode
The role of the growth mode on lateral composition modulation is studied in short period superlattices of AlAs/InAs and GaAs/InAs. Reflection high energy electron diffraction and scanning tunneling microscopy are used to monitor the growth mode and the quality of the interfaces. Cross-sectional transmission electron microscopy indicates that samples that grow via the layer-by-layer growth mode do not exhibit lateral composition modulation and the superlattice structure is well defined. Lateral composition modulation forms when roughening occurs during growth. However, too much roughening, i.e., three-dimensional island nucleation destroys the regularity of the composition modulation in both the lateral and vertical directions. These results are in general agreement with theoretical predictions. © 2001 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70098/2/APPLAB-79-25-4118-1.pd
Atomic Size Mismatch Strain Induced Surface Reconstructions
The effects of lattice mismatch strain and atomic size mismatch strain on surface reconstructions are analyzed using density functional theory. These calculations demonstrate the importance of an explicit treatment of alloying when calculating the energies of alloyed surface reconstructions. Lattice mismatch strain has little impact on surface dimer ordering for the α2(2×4) reconstruction of GaAs alloyed with In. However, atomic size mismatch strain induces the surface In atoms to preferentially alternate position, which, in turn, induces an alternating configuration of the surface anion dimers. These results agree well with experimental data for α2(2×4) domains in InGaAs∕GaAs surfaces
Surface reconstructions of In-enriched InGaAs alloys
The atomic structure of In0.81Ga0.19As/InPIn0.81Ga0.19As/InP alloy layers was examined using in situ scanning tunneling microscopy. The (2×3) reconstruction observed during growth by reflection high-energy electron diffraction represents a combination of surface structures, including a β2(2×4) commonly observed on GaAs(001) and InAs(001) surfaces, and a disordered (4×3) that is unique to alloy systems. The proposed (4×3) structure is comprised of both anion and cation dimers. Empty and filled states images show that the features reverse contrast with sample bias, in agreement with the model. © 2003 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70065/2/APPLAB-83-7-1361-1.pd
Photoluminescence studies of lateral composition modulated short-period AlAs/InAs superlattices
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Photoluminescence Studies of Lateral Composition Modulated Short-Period AlAs/InAs Superlattices
We present low temperature photoluminescence data for a series of spontaneous lateral composition modulation in (AlAs){sub m}/(InAs){sub n} short period superlattices on InP with differing average lattice constants, i.e., varying global strain. The low temperature photoluminescence peak energies were found to be much lower than the corresponding energy expected for the equivalent In{sub x}Al{sub 1{minus}x}As alloy. The bandgap energy reductions are found to approach 500 meV and this reduction is found to correlated with the strength of the composition modulation wave amplitude
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RTN2 deficiency results in an autosomal recessive distal motor neuropathy with lower limb spasticity.
Heterozygous RTN2 variants have been previously identified in a limited cohort of families affected by autosomal dominant spastic paraplegia (SPG12-OMIM:604805) with a variable age of onset. Nevertheless, the definitive validity of SPG12 remains to be confidently confirmed due to the scarcity of supporting evidence. In this study, we identified and validated seven novel or ultra-rare homozygous loss-of-function RTN2 variants in 14 individuals from seven consanguineous families with distal hereditary motor neuropathy (dHMN) using exome, genome and Sanger sequencing coupled with deep-phenotyping. All affected individuals (seven males and seven females, aged 9-50 years) exhibited weakness in the distal upper and lower limbs, lower limb spasticity and hyperreflexia, with onset in the first decade of life. Nerve conduction studies revealed axonal motor neuropathy with neurogenic changes in the electromyography. Despite a slowly progressive disease course, all patients remained ambulatory over a mean disease duration of 19.71 ± 13.70 years. Characterization of Caenorhabditis elegans RTN2 homologous loss-of-function variants demonstrated morphological and behavioural differences compared with the parental strain. Treatment of the mutant with an endoplasmic/sarcoplasmic reticulum Ca2+ reuptake inhibitor (2,5-di-tert-butylhydroquinone) rescued key phenotypic differences, suggesting a potential therapeutic benefit for RTN2-disorder. Despite RTN2 being an endoplasmic reticulum (ER)-resident membrane shaping protein, our analysis of patient fibroblast cells did not find significant alterations in ER structure or the response to ER stress. Our findings delineate a distinct form of autosomal recessive dHMN with pyramidal features associated with RTN2 deficiency. This phenotype shares similarities with SIGMAR1-related dHMN and Silver-like syndromes, providing valuable insights into the clinical spectrum and potential therapeutic strategies for RTN2-related dHMN
Influence of Neonatal Hypothyroidism on Hepatic Gene Expression and Lipid Metabolism in Adulthood
Thyroid hormones are required for normal growth and development in mammals. Congenital-neonatal hypothyroidism (CH) has a profound impact on physiology, but its specific influence in liver is less understood. Here, we studied how CH influences the liver gene expression program in adulthood. Pregnant rats were given the antithyroid drug methimazole (MMI) from GD12 until PND30 to induce CH in male offspring. Growth defects due to CH were evident as reductions in body weight and tail length from the second week of life. Once the MMI treatment was discontinued, the feed efficiency increased in CH, and this was accompanied by significant catch-up growth. On PND80, significant reductions in body mass, tail length, and circulating IGF-I levels remained in CH rats. Conversely, the mRNA levels of known GH target genes were significantly upregulated. The serum levels of thyroid hormones, cholesterol, and triglycerides showed no significant differences. In contrast, CH rats showed significant changes in the expression of hepatic genes involved in lipid metabolism, including an increased transcription of PPARα and a reduced expression of genes involved in fatty acid and cholesterol uptake, cellular sterol efflux, triglyceride assembly, bile acid synthesis, and lipogenesis. These changes were associated with a decrease of intrahepatic lipids. Finally, CH rats responded to the onset of hypothyroidism in adulthood with a reduction of serum fatty acids and hepatic cholesteryl esters and to T3 replacement with an enhanced activation of malic enzyme. In summary, we provide in vivo evidence that neonatal hypothyroidism influences the hepatic transcriptional program and tissue sensitivity to hormone treatment in adulthood. This highlights the critical role that a euthyroid state during development plays on normal liver physiology in adulthood
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