Annotation management: a Group decision support system for nurses tasks

International audienceWe develop a 5-year empirical investigation that is giving us broad and deep insights to characterise activity management in the palliative ward of an oncology hospital, and offer effective support for group decision-making and collaborative activity of caregivers. Following this observation period, we propose a software prototype based upon annotations in which dealing with patients’ state and evolution is a complex organisational task. We based our conception of an annotation tool on the observations of the rich writing practices of medical professionals. We rely on the innovative strategy of intermediate management to introduce a new technology able to bridge heterogeneous, valuable data flows that addresses both management support and activity support in a single tool

Interdisziplinäre Tagung zur Geschichte der neuzeitlichen Metallgeldproduktion: Projektberichte und Forschungsergebnisse; Beiträge zur Tagung in Stolberg (Harz) im April 2006 / veranstaltet von der Numismatischen Kommission der Länder in der Bundesrepublik Deutschland und der Braunschweigischen Wissenschaftlichen Gesellschaft, Teil 2

International audiencenon communiqu

The effect of food consumption on lumefantrine bioavailability in African children receiving artemether–lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria

Summary Objectives Artemether-lumefantrine (AL) is first-line treatment for uncomplicated malaria in many African countries. Concomitant food consumption may affect absorption of lumefantrine but data in the most important target population, i.e. children, are lacking. Therefore, we evaluated the effect of food intake on oral lumefantrine bioavailability in African children with malaria. Methods In a randomised, investigator-blinded, multicentre phase III efficacy trial, 899 infants and children with acute uncomplicated Plasmodium falciparum malaria received six doses of AL according to body weight over 3 days either as crushed tablets (Coartem((R))) or as dispersible tablets. Single blood samples were obtained for lumefantrine plasma concentration determination in a subset of 621 patients, and a two-compartment pharmacokinetic model was constructed. Results The mean observed lumefantrine plasma concentration for crushed tablet and dispersible tablet, respectively, was 100% and 55% higher with a concomitant meal at the time of dose intake than when taken alone. Similarly, consumption of milk (the most common meal) increased model-estimated lumefantrine bioavailability by 57% (90% CI: 29-96%) with crushed tablets and 65% (90% CI: 28-109%) with dispersible tablets compared to no food. The 28-day PCR-corrected cure rate (primary study endpoint) in the evaluable population was 582/587 [99.1% (95% CI: 98.0-99.7%)] and was not related to food intake. Conclusions AL was highly efficacious. Concomitant food intake increased lumefantrine absorption in children with malaria

A dietary perspective of cat-human interactions in two medieval harbors in Iran and Oman revealed through stable isotope analysis

Abstract Cats are hypercarnivorous, opportunistic animals that have adjusted to anthropogenic environments since the Neolithic period. Through humans, either by direct feeding and/or scavenging on food scraps, the diet of cats has been enriched with animals that they cannot kill themselves (e.g., large mammals, fish). Here, we conducted carbon and nitrogen stable isotope ratio analysis to reconstruct the diet of medieval cats and investigate cat-human interactions in two medieval harbor sites (Qalhât, Oman and Siraf, Iran). The analysis included 28 cat individuals and 100 associated marine and terrestrial faunal samples pertaining to > 30 taxa. The isotopic results indicate a high marine protein-based diet for the cats from Qalhât and a mixed marine-terrestrial (C4) diet for the cats from Siraf. Cats at these sites most likely scavenged on both human food scraps and refuse related to fishing activities, with differences in the two sites most likely associated with the availability of marine resources and/or the living conditions of the cats. By shedding light on the dietary habits of cats from two medieval harbors in the Arabian Gulf and Gulf of Oman, this study illustrates the potential of stable isotope analysis in reconstructing human-cat interactions in the past