The Distribution of Atomic Hydrogen Around Two Irregular Galaxies

We present radio interferometric observations of two irregular galaxies that were candidates for having unusually extended HI emission. The galaxies, UGC 199 and DDO 26, otherwise appeared to be normal, low-luminosity systems with modest star-formation rates. To a detection limit of 2--3E19 /cm^2 at a resolution of about 50", however, the HI around neither galaxy is unusually extended compared to other irregulars. The HI around UGC 199 appears as a regular, symmetric distribution with regular rotation and a maximum rotation speed of about 80 km/s. By contrast, the HI around DDO 26 shows a concentration into two blobs with an arm in the outer parts to the northwest and some additional emission to the northwest of that. The kinematical major axis is approximately 75 deg from the HI and optical morphological axis which is unusual for Im galaxies. In addition the velocity field in the outer parts of the galaxy is messy and the velocity profiles at the two HI peaks are broad. We suggest that DDO 26 has been perturbed externally or may be two dwarfs in the process of merging.Comment: To be published in AJ, May 200

Evaluation of fostering network Scottish care mentoring projects

Looked after children and young people are some of the most vulnerable in our society. For Scotland’s Children highlighted the ‘continuing failure of many local authorities as ‘corporate parents’ to provide these young people with the care and education they are entitled to by law’ (Scottish Executive, 2001, p. 10). One of the major issues facing looked after young people is the process of transition from care to independence. It is a time when they have ‘a right to expect the sort of help that loving parents would provide for their children, help to reach their full potential, and the same chance to make mistakes secure in the knowledge that there is a safety net of support’ (Jamieson, 2002, p. 2). However, over a number of years, research has highlighted the poor outcomes for children leaving care. Longitudinal studies which have followed up children and young people in care as part of national cohort studies present the stark contrast in life outcomes between those who have experienced care and those who have not. Cheung and Heath (1994) compare these two groups at age 33. Only one fifth of those who had been in care had achieved O levels compared to one-third of those who had not; only half as many had achieved A levels. Only one in a hundred of those who had been in care achieved a university degree compared to one on ten of those who had not. Two fifths of those who had been in care had no formal qualifications compared to one in seven (Cheung and Heath, 1994). This lack of qualifications converted into lack of success in the job market with three times as many being unemployed (10.8 % compared to 3.6 %) and larger proportions having manual jobs as opposed to professional or non-manual jobs

Promoting nutrition sensitive and climate smart agriculture through increased use of traditional underutilised species in the Pacific

Poster presented at Tropentag 2014. International Conference on Research on Food Security, Natural Resource Management and Rural Development. "Bridging the Gap between Increasing Knowledge and Decreasing Resources" Prague (Czech Republic) Sep 17-19 2014

CARMIL family proteins as multidomain regulators of actin-based motility

CARMILs are large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper of actin filament barbed ends in cells. CARMILs bind directly to CP and induce a conformational change that allosterically decreases but does not abolish its actin-capping activity. The CP-binding domain of CARMIL consists of the CP-interaction (CPI) and CARMIL-specific interaction (CSI) motifs, which are arranged in tandem. Many cellular functions of CARMILs require the interaction with CP; however, a more surprising result is that the cellular function of CP in cells appears to require binding to a CARMIL or another protein with a CPI motif, suggesting that CPI-motif proteins target CP and modulate its actin-capping activity. Vertebrates have three highly conserved genes and expressed isoforms of CARMIL with distinct and overlapping localizations and functions in cells. Various domains of these CARMIL isoforms interact with plasma membranes, vimentin intermediate filaments, SH3-containing class I myosins, the dual-GEF Trio, and other adaptors and signaling molecules. These biochemical properties suggest that CARMILs play a variety of membrane-associated functions related to actin assembly and signaling. CARMIL mutations and variants have been implicated in several human diseases. We focus on roles for CARMILs in signaling in addition to their function as regulators of CP and actin. </jats:p

The Outer Edges of Dwarf Irregular Galaxies: Stars and Gas

We have in recent years come to view dwarf galaxy evolution in the broader context of the cosmic evolution of large-scale structure. Dwarf galaxies, as the putative building blocks of hierarchical galaxy formation, and also as the most numerous galaxies in the Universe, play a central role in cosmic evolution. In particular, the interplay of galactic and intergalactic material around dwarf irregulars must be more extensive than in more massive disk galaxies because of their lower gravitational potential and lower interstellar pressures. The outer regions of dwarf irregular galaxies therefore yield vital clues to the dominant processes in this interaction zone. The Workshop addressed a number of questions related to the role of the outer regions in the evolution of dwarf galaxies and broader consequences. On-line Workshop Proceedings are at http://www.lowell.edu/Workshops/Lowell02/Comment: Summary of the 2002 Lowell Observatory Workshop, to appear in PASP Conference Highlights; 6 pp, uses aaspp4.sty. On-line Proceedings at http://www.lowell.edu/Workshops/Lowell02

New light on the ‘Drummer of Tedworth’: conflicting narratives of witchcraft in Restoration England

This paper presents a definitive text of hitherto little-known early documents concerning ‘The Drummer of Tedworth’, a poltergeist case that occurred in 1662-3 and became famous not least due to its promotion by Joseph Glanvill in his demonological work, Saducismus Triumphatus. On the basis of these and other sources, it is shown how responses to the events at Tedworth evolved from anxious piety on the part of their victim, John Mompesson, to confident apologetic by Glanvill, before they were further affected by the emergence of articulate scepticism about the case

Length control of microtubules by depolymerizing motor proteins

In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the microtubule tip(s) by diffusion or directed walk and, then, depolymerize the microtubule from the tip(s) after accumulating there. We develop a quantitative model to study the depolymerizing action of such a generic motor protein, and its possible effects on the length distribution of microtubules. We show that, when the motor protein concentration in solution exceeds a critical value, a steady state is reached where the length distribution is, in general, non-monotonic with a single peak. However, for highly processive motors and large motor densities, this distribution effectively becomes an exponential decay. Our findings suggest that such motor proteins may be selectively used by the cell to ensure precise control of MT lengths. The model is also used to analyze experimental observations of motor-induced depolymerization.Comment: Added section with figures and significantly expanded text, current version to appear in Europhys. Let

A comparison of Olpidium isolates from a range of host plants using internal transcribed spacer sequence analysis and host range studies

Olpidium brassicae is a ubiquitous obligate root-infecting fungal pathogen. It is an important vector of a wide range of plant viruses. Olpidium isolates that infected brassica plants did not infect lettuce plants and vice-versa. Host range tests, PCR amplification and sequencing of the internal transcribed spacer (ITS) and 5.8S regions of 25 Olpidium isolates from brassica, carrot, cucumber and lettuce originating from four continents revealed differences between isolates. Based on their ability to infect lettuce and brassicas and the differences between their ITS1, 5.8S and ITS2 regions they could be separated into a number of distinct groups. Comparisons with other published sequences revealed two distinct genetic groups of brassica-infecting isolates, two distinct groups of lettuce-infecting isolates, one of which contained a carrot-infecting isolate and a distinct group comprising a cucumber-infecting isolate and a melon-infecting isolate. The possibility of the isolates belonging to three distinct species is discussed

The Complexity of Admissibility in Omega-Regular Games

Iterated admissibility is a well-known and important concept in classical game theory, e.g. to determine rational behaviors in multi-player matrix games. As recently shown by Berwanger, this concept can be soundly extended to infinite games played on graphs with omega-regular objectives. In this paper, we study the algorithmic properties of this concept for such games. We settle the exact complexity of natural decision problems on the set of strategies that survive iterated elimination of dominated strategies. As a byproduct of our construction, we obtain automata which recognize all the possible outcomes of such strategies