Developing competency profiles of IT specialists based on semantic analysis of vacancies

The article focuses on applying Big Data processing methods and tools for creating specialists' competency profiles. It covers the approach developed to formulate the key competencies required for the IT vacancies. The first stage of the research includes carrying out a semantic analysis of the IT vacancies database. The second stage includes clustering of the results of semantic analysis and using them for building the map of the competencies of IT specialists. The modularity score reveals a significant isolation of the specialties in this area. The performed approach can be implemented in designing the professional standards and competency based education programs. © Published under licence by IOP Publishing Ltd

Melting Point and Lattice Parameter Shifts in Supported Metal Nanoclusters

The dependencies of the melting point and the lattice parameter of supported metal nanoclusters as functions of clusters height are theoretically investigated in the framework of the uniform approach. The vacancy mechanism describing the melting point and the lattice parameter shifts in nanoclusters with decrease of their size is proposed. It is shown that under the high vacuum conditions (p<10^-7 torr) the essential role in clusters melting point and lattice parameter shifts is played by the van der Waals forces of cluster-substrate interation. The proposed model satisfactorily accounts for the experimental data.Comment: 6 pages, 3 figures, 1 tabl

Wheat landraces as sources of high grain quality and nutritional properties

Background. Improving the grain quality of modern spring bread wheat cultivars is a highly relevant task of breeding. To solve this problem, old and local wheat varieties (landraces) are of considerable interest. A rich collection of them is available among the plant genetic resources preserved at VIR. With this in view, the aim of this research was to identify sources of high protein, gluten, macro- and micronutrient content out of the landraces from the VIR collection for improvement of wheat grain quality through breeding.Materials and methods. Field and laboratory research were conducted in the experimental field of Omsk State Agrarian University under the conditions of the southern forest-steppe of Western Siberia in 2020–2021. Sowing was carried out on fallow on conventional sowing dates. Mineral composition in the grain of the studied landraces was analyzed at the Kurchatov Genomic Center, Novosibirsk, using atomic absorption spectrometry techniques.Results. The research results showed that landraces from different regions of Russia, Kazakhstan, Tajikistan, and Kyrgyzstan were characterized by high levels of protein (18.4–18.8%) and gluten (35.9–36.0%) in grain. Landraces from Kazakhstan had low Zn content (on average 38.3 mg/kg), while those from Kyrgyzstan, on the contrary, had high content of Zn (41.9 mg/kg) and Fe (55.1 mg/kg), and landraces from Tajikistan had high K content (3820 mg/kg). A positive relationship between the concentrations of Mg, Mn, Fe, and Zn was found in the grain of wheat landraces.Conclusion. Wheat landraces are of interest as genetic resources for the development of high-protein cultivars with improved nutritional value of grain for the milling and breadmaking industries

Development of a cooling system for 6U module based on Elbrus microprocessor

The article discusses the design features of cooling systems for compact Eurocard format modules based on the Elbrus microprocessor. The issue of ensuring the necessary thermal regime of the processor module in the space shortage conditions in order to accommodate the cooling system has been solved. The estimated calculation showed the underperformance of the passive cooling of the Elbrus-4S microprocessor with a heat output of 60 W. In this regard, a 3D model of an active cooling system with 5.5×10.3×4.6 cm dimensions was developed. Thermal calculations were performed using the SolidWorks Flow Simulation program in order to optimize the radiator geometry and fan speed. It was assumed that an optimized cooling system will ensure that the chip temperature of the Elbrus-4S processor is no more than +87 °C (at an ambient temperature of +55 °C). Based on the results of the study, three prototypes were produced for testing. Further tests conducted on prototypes showed the efficiency of the cooling system and the high accuracy of the simulation results. During tests in a climatic chamber at a temperature of +55 °C, the temperature on the microprocessor chip did not exceed +84 °C (a difference of 3 °C compared to the estimated one)

DAILY BLOOD PRESSURE MONITORING OF YOUNG PATIENTS WITH THE SYNDROME OF CONNECTIVE TISSUE DISPLASIA

The study is focused on the estimation of daily BP profiles in young patients with the syndrome of connective tissue displasia. A considerable party of them shows a strong evidence of altered balance between pressoric and depressoric mechanisms of BP regulation. We have verified two kinds of cardiovascular reactions in connective tissue displasia. Half of those examined, according to the postural test, exhibit altered adaptive potential

DISTRIBUTION OF ALLELIC VARIANTS OF Wx GENES IN THE COMMON WHEAT COLLECTION MADE AT THE KRASNODAR LUKYANENKO RESEARCH INSTITUTE OF AGRICULTURE

Molecular marker-based identification of allelic variants of Wx genes has been performed in the collection of 99 common wheat cultivars and breeding lines developed at the Krasnodar Lukyanenko Research Institute of Agriculture.Use of two molecular markers to the Wx-А1 gene shows that cultivars ‘Starshina’ and ‘Sila’ carry null alleles of Wx-А1. Studies with four systems of molecular markers indicate that cultivars ‘Nota’ and ‘Lastochka’ possess the Wx-B1e allele. No cultivars with null-alleles of Wx-B1 have been found. Only wild-type alleles are present in the Wx-D1 locus

Adiponectin gene single-nucleotide polymorphisms in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

Background. It is generally believed that environmental and genetic factors interact with the formation of nonalcoholic fatty liver disease (NAFLD) phenotype and determine its progression. Both NAFLD and type 2 diabetes (T2D) are heterogeneous diseases with common pathogenic pathways. Adiponectin is an adipokine, which increases the sensitivity of hepatocytes and muscle to insulin, modulates energy homeostasis, glucose/lipid metabolism, and inflammatory response. A number of significant adiponectin gene polymorphisms are known in this area. The purpose of the study was to evaluate the possible association between two adiponectin gene (ADIPOQ) variants, +276 G/T (rs1501299) and –11391 G/A (rs17300539), and susceptibility to NAFLD in T2D patients of Ukrainian population. Materials and methods. Case-control study included a total of 155 persons with T2D (males/females: 77/78, age 54.55 ± 0.73 years, T2D duration 6.66 ± 0.49 years, body mass index 32.20 ± 0.43 kg/m2, waist/hip circumference 0.98 ± 0.01 m, HbA1c 7.26 ± 0.11 %) for biochemical characteristics (lipid profile, non-esterified fatty acids (NEFA), insulin, total adiponectin, etc.), including 90 T2D patients with NAFLD, 245 — with rs1501299 genotyping, 155 — with rs17300539 genotyping, and 51 sex and age-matched control subjects. The +276 G/T and –11391 G/A were determined by polymerase chain reaction — restriction fragment length polymorphism method with endonucleases Mva1269I (BsmI) and MspI (HpaII). Insulin resistance (IR) was assessed using homeostasis model assessment (HOMA) algorithm and as adipose IR (Adipo-IR, NEFAxinsulin). Unpaired Student’s t test, c2 test and Spearman’s rank order were used. To predict the probabilities of genetic risk in NAFLD, the odds ratio (OR) and 95% confidence interval (CI) were calculated. Results. T2D patients were characterized by overweight and obesity, which were more significant in the presence of NAFLD (p < 0.01). It was accompanied by an increase in НОМА-IR (p < 0.05) and triglycerides (p < 0.001) levels. We found that Adipo-IR was higher in patients with T2D as compared to the controls (p < 0.001), and this index was significantly increased in T2D patients with NAFLD in contrast to obesity-matched persons without NAFLD (190.18 ± 22.15 vs 133.32 ± 13.58 mmol/L·pmol/L, p < 0.02), with negative correlation between Adipo-IR and adiponectin level in T2D patients with NAFLD only (rs = –0.350, p = 0.021). Stratification of non-NAFLD patients by +276G/T genotype suggests the prevalence of GT- and TT-genotypes. Thus, the rs1501299 G-allele increased the risk of NAFLD in comparison with T-allele (OR = 4.44, 95% CI = 2.89–6.81, p < 0.05). We also found a significant difference in the frequency of –11391G/A between T2D and control groups, but not between the patients with and without NAFLD. We observed that the haplotype of GT/GG had been more common in T2D with NAFLD, and twice less often detected in patients without hepatic disease (33 and 16.49 %, respectively, p < 0.05). Conclusions. We can recommend Adipo-IR index as a predictive marker for the NAFLD development and the indicator for therapy success in T2D patients. We established new genetic markers (rs1501299 G-allele, rs17300539 and rs1501299 GG/GG and GT/GG haplotypes, respectively) for the risk of NAFLD development in T2D patients

Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus

The authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranu­lin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis