Les tumeurs benignes de la parotide

Introduction : Les tumeurs parotidiennes bénignes sont caractérisées par une grande diversité histologique. Les indications thérapeutiques ne sont pas encore bien codifiées et restent un sujet de controverse.Matériel et méthodes : Nous rapportons une étude rétrospective à propos de 48 cas de tumeurs parotidiennes bénignes, colligés sur une période de 7 ans (2004-2010). Tous les patients ont bénéficié d’un examen ORL complet, d’un bilan biologique et radiologique. Le traitement était chirurgical dans tous les cas.Résultats : L’âge moyen était de 46 ans et le sex-ratio 1,52. Le motif de consultation était dans tous les cas une tuméfaction au niveau de la région parotidienne. L’échographie cervicale a confirmé le siège intra-parotidien dans tous les cas. L’IRM était pratiquée chez 28 patients. Le cystadénolymphome était évoqué dans 6 cas et l’adénome pléomorphe dans 22 cas. Une cytoponction a été pratiquée chez 8 patients et a montré un aspect en faveur d’adénome pléomorphe dans 6 cas et de cystadénolymphome dans 2 cas. Tous les patients ont été opérés sous anesthésie générale. La tumeur était au dépends du lobe superficiel dans 43 cas et du lobe profond dans 5 cas. Une parotidectomie totale a été pratiquée chez les 5 patients ayant une tumeur au dépends du lobe profond. Parmi les 43 patients ayant une tumeur au dépends du lobe superficiel, une parotidectomie totale a été pratiquée chez 5 patients, une parotidectomie exofaciale chez 35 patients et une simple énucléation tumorale dans 3 cas. L’examen anatomopathologique définitif était concordant avec l’examen extemporané dans 100% des cas. Au total, nous avions 31 cas d’adénome pléomorphe et 17 cas de cystadénolymphome. Des complications post-opératoires étaient présentes dans 9 cas. L’évolution ultérieure a été marquée par l’absence de récidive dans tous les cas, avec un recul moyen de 28 mois.Conclusion : Le développement des techniques de l’imagerie a permis actuellement d’évoquer le diagnostic de bénignité d’une tumeur parotidienne et même d’évoquer fortement un diagnostic anatomopathologique. Le choix de l’intervention chirurgicale est guidé par la localisation et l’étendue de la tumeur et par le type histologique.Mots-clés : tumeur bénigne, glande parotide, imagerie par résonance magnétique, cytoponction, parotidectomie, nerf facialIntroduction: Benign parotid tumors are characterized by high histological diversity. Therapeutic indications are not well codified and remain a subject of controversy.Materials and Methods: We report a retrospective study of 48 cases of benign parotid tumors, collected over a period of 7 years (2004-2010). All patients underwent complete ENT examination, biological and radiological assessment. Treatment was surgical in all cases.Results : The mean age was 46 years and the sex ratio 1.52. Tumefaction in the parotid region was the presenting symptom in all cases. Cervical ultrasound confirmed the intra-parotid location in all cases. MRI was performed in 28 patients. Cystadenolymphoma was suggested in 6 cases and pleomorphic adenoma in 22 cases. A fine-needle aspiration was performed in 8 patients and showed pleomorphic adenoma in 6 cases and cystadenolymphoma in 2 cases. All patients were operated under general anesthesia. The tumor was at the expense of the superficial lobe in 43 cases and the deep lobe in 5 cases. A total parotidectomy was performed in 5 patients having a deep lobe tumor. Among the 43 patients having a superficial lobe tumor, a total parotidectomy was performed in 5 patients, an exofacialparotidectomy in 35 patients and a single tumor enucleation in 3 cases. The final histological examination was consistent with the frozen section in 100% of cases. In total, we had 31 cases of pleomorphic adenoma and 17 cases of cystadenolymphoma. Postoperative complications were present in 9 cases. The subsequent evolution was marked by the absence of recurrence in all cases, with a mean follow-up period of 28 months.Conclusion : The development of imaging techniques has currently allowed to suggest the diagnosis of benignity of a parotid tumor, and even to highly evoke the pathological diagnosis. The choice of surgical procedure is guided by the location and extent of the tumor and by the histological type.Keywords : benign tumor, parotid gland, magnetic resonance imaging, fine-needle aspiration, parotidectomy, facial nerv

MHD Forced Convection Laminar Boundary Layer Flow of Alumina-Water Nanofluid over a Moving Permeable Flat Plate with Convective Surface Boundary Condition

This paper analyses a two-dimensional steady forced convection boundary layer viscous incompressible flow of alumina-water nanofluid over a moving permeable vertical flat plate under the effect of a magnetic field normal to the plate. Thermal convective surface boundary condition is applied. The nanofluid formulated in the present study is water dispersed with various volumetric fractions of the alumina (Al2O3) nanoparticles. The plate velocity and the free stream velocities are considered to be proportional to , while the magnetic field and suction velocities are taken to be proportional to . The similarity solution of the governing problem is obtained. Numerical studies are presented to show the effect of the nanoparticle volume fraction the convective heat transfer parameter , the power law exponent , the wall velocity parameter , and the suction parameter fw on the velocity, temperature, skin-friction coefficient, and Nusselt number

Interfaces in alfa fibre-polypropylene matrix composites

Model composites with Polypropylene (PP) as matrix and alfa fibres (cellulose-based fibres obtained from the esparto grass of the subsaarian dry regions of Tunisia) were prepared for fibre/matrix interfacial characterization studies. The matrices tested were PP and PP combined with PP modified with maleic anhydride (PP-g-MA). The surface of the alfa fibres was treated by air plasma treatment. The adhesion between the untreated and treated fibres and both matrices was studied using the fragmentation test method. Composites with 10% weight of fibres were prepared by melt extrusion and injection moulding, and the specimens obtained tested for tensile properties. The fracture surfaces of the composites, obtained at low temperature, were observed by scanning electron microscopy. The presence of a small concentration of maleic anhydride grafted to the polymer matrix was found to be of the utmost importance for the establishment of a good fibre/matrix interface. The air plasma treatment had a cleaning effect of the fibre’s surface.Institute for International Scientific and Technological Cooperation – Portugal/Tunisi

Quadracyclic adenine: a non-perturbing fluorescent adenine analogue.

Fluorescent-base analogues (FBAs) comprise a group of increasingly important molecules for the investigation of nucleic acid structure and dynamics as well as of interactions between nucleic acids and other molecules. Here, we report on the synthesis, detailed spectroscopic characterisation and base-pairing properties of a new environment-sensitive fluorescent adenine analogue, quadracyclic adenine (qA). After developing an efficient route of synthesis for the phosphoramidite of qA it was incorporated into DNA in high yield by using standard solid-phase synthesis procedures. In DNA qA serves as an adenine analogue that preserves the B-form and, in contrast to most currently available FBAs, maintains or even increases the stability of the duplex. We demonstrate that, unlike fluorescent adenine analogues, such as the most commonly used one, 2-aminopurine, and the recently developed triazole adenine, qA shows highly specific base-pairing with thymine. Moreover, qA has an absorption band outside the absorption of the natural nucleobases (>300 nm) and can thus be selectively excited. Upon excitation the qA monomer displays a fluorescence quantum yield of 6.8 % with an emission maximum at 456 nm. More importantly, upon incorporation into DNA the fluorescence of qA is significantly less quenched than most FBAs. This results in quantum yields that in some sequences reach values that are up to fourfold higher than maximum values reported for 2-aminopurine. To facilitate future utilisation of qA in biochemical and biophysical studies we investigated its fluorescence properties in greater detail and resolved its absorption band outside the DNA absorption region into distinct transition dipole moments. In conclusion, the unique combination of properties of qA make it a promising alternative to current fluorescent adenine analogues for future detailed studies of nucleic acid-containing systems

Immunochromatographic rK39 strip test in the serodiagnosis of visceral leishmaniasis in Tunisia

International audienceThe performance of the rK39 strip test in the diagnosis of Tunisian visceral leishmaniasis (VL) was evaluated and compared with that of immunofluorescent antibody test (IFAT). A total of 929 sera, including 574 from VL patients, 54 from cutaneous leishmaniasis (CL) patients, 42 from patients with other protozoan diseases, 152 from patients with non-parasitic diseases and 107 from healthy controls, were used in the study. The sensitivity and specificity of the rK39 strip test were 87.1 and 94.4%, respectively. Sixteen CL sera showed positive results, suggesting that the rK39 strip test is not restricted to Leishmania donovani complex detection. IFAT was comparatively more sensitive (98.9%) but slightly less specific (90.7%). Despite cross-reactivity shown by CL sera, the rK39 strip test can be recommended for the routine diagnosis of VL in Tunisia, as VL and CL are distinct clinical. entities. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved

Structure Cristalline Et Caracterisation D’un Nouveau Pyrazolotriazine Phosphonaté Non Centrosymetrique

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