44,383 research outputs found
Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes
FAMILY JUSTICE AND FAMILY VALUES ACCORDING TO LORD DENNING
FAMILY JUSTICE AND FAMILY VALUES ACCORDING TO LORD DENNIN
Finite volume study of electric polarizabilities from lattice QCD
Knowledge of the electric polarizability is crucial to understanding the
interactions of hadrons with electromagnetic fields. The neutron polarizability
is very sensitive to the quark mass and is expected to diverge in the chiral
limit. Here we present results for the electric polarizability of the neutron,
neutral pion, and neutral kaon on eight ensembles with nHYP-smeared clover
dynamical fermions with two different pion masses (227 and 306 MeV). These are
currently the lightest pion masses used in polarizability studies. For each
pion mass we compute the polarizability at four different volumes and perform
an infinite volume extrapolation for the three hadrons. Along with the infinite
volume extrapolation we conduct a chiral extrapolation for the kaon
polarizability to the physical point. We compare our results for the neutron
polarizability to predictions from chiral perturbation theory.Comment: 7 pages, 11 figure
The intrinsic strangeness and charm of the nucleon using improved staggered fermions
We calculate the intrinsic strangeness of the nucleon, - ,
using the MILC library of improved staggered gauge configurations using the
Asqtad and HISQ actions. Additionally, we present a preliminary calculation of
the intrinsic charm of the nucleon using the HISQ action with dynamical charm.
The calculation is done with a method which incorporates features of both
commonly-used methods, the direct evaluation of the three-point function and
the application of the Feynman- Hellman theorem. We present an improvement on
this method that further reduces the statistical error, and check the result
from this hybrid method against the other two methods and find that they are
consistent. The values for and found here, together with
perturbative results for heavy quarks, show that dark matter scattering through
Higgs-like exchange receives roughly equal contributions from all heavy quark
flavors.Comment: 17 pages, 14 figure
Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis
Gap junctions are intercellular channels that allow the passage of ions and small molecules between cells. In the nervous system, gap junctions mediate electrical coupling between neurons. Despite sharing a common topology and similar physiology, two unrelated gap junction protein families exist in the animal kingdom. Vertebrate gap junctions are formed by members of the connexin family, whereas invertebrate gap junctions are composed of innexin proteins. Here we report the cloning of two innexins from the leech Hirudo medicinalis. These innexins show a differential expression in the leech CNS: Hm-inx1 is expressed by every neuron in the CNS but not in glia, whereas Hm-inx2 is expressed in glia but not neurons. Heterologous expression in the paired Xenopus oocyte system demonstrated that both innexins are able to form functional homotypic gap junctions. Hm-inx1 forms channels that are not strongly gated. In contrast, Hm-inx2 forms channels that are highly voltage-dependent; these channels demonstrate properties resembling those of a double rectifier. In addition, Hm-inx1 and Hm-inx2 are able to cooperate to form heterotypic gap junctions in Xenopus oocytes. The behavior of these channels is primarily that predicted from the properties of the constituent hemichannels but also demonstrates evidence of an interaction between the two. This work represents the first demonstration of a functional gap junction protein from a Lophotrochozoan animal and supports the hypothesis that connexin-based communication is restricted to the deuterostome clade
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