4,165 research outputs found
Wall jet analysis for circulation control aerodynamics. Part 2: Zonal modeling concepts for wall jet/potential flow coupling
Work currently in progress to update an existing transonic circulation control airfoil analysis method is described. Existing methods suffer from two dificiencies: the inability to predict the shock structure of the underexpanded supersonic jets; and the insensitivity of the calculation to small changes in the Coanda surface geometry. A method developed for the analysis of jet exhaust plumes in supersonic flow is being modified for the case of the underexpanded wall jet. In the subsonic case, the same wall jet model was modified to include the calculation of the normal pressure gradient. This model is currently being coupled with the transonic circulation control airfoil analysis
Wall jet analysis for circulation control aerodynamics. Part 1: Fundamental CFD and turbulence modeling concepts
An overview of parabolic and PNS (Parabolized Navier-Stokes) methodology developed to treat highly curved sub and supersonic wall jets is presented. The fundamental data base to which these models were applied is discussed in detail. The analysis of strong curvature effects was found to require a semi-elliptic extension of the parabolic modeling to account for turbulent contributions to the normal pressure variations, as well as an extension to the turbulence models utilized, to account for the highly enhanced mixing rates observed in situations with large convex curvature. A noniterative, pressure split procedure is shown to extend parabolic models to account for such normal pressure variations in an efficient manner, requiring minimal additional run time over a standard parabolic approach. A new PNS methodology is presented to solve this problem which extends parabolic methodology via the addition of a characteristic base wave solver. Applications of this approach to analyze the interaction of wave and turbulence processes in wall jets is presented
Spectroscopy of PTCDA attached to rare gas samples: clusters vs. bulk matrices. I. Absorption spectroscopy
The interaction between PTCDA (3,4,9,10-perylene-tetracarboxylic-dianhydride)
and rare gas or para-hydrogen samples is studied by means of laser-induced
fluorescence excitation spectroscopy. The comparison between spectra of PTCDA
embedded in a neon matrix and spectra attached to large neon clusters shows
that these large organic molecules reside on the surface of the clusters when
doped by the pick-up technique. PTCDA molecules can adopt different
conformations when attached to argon, neon and para-hydrogen clusters which
implies that the surface of such clusters has a well-defined structure and has
not liquid or fluxional properties. Moreover, a precise analysis of the doping
process of these clusters reveals that the mobility of large molecules on the
cluster surface is quenched, preventing agglomeration and complex formation
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Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota.
BackgroundProbiotics decrease the risk of necrotizing enterocolitis (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis (B. infantis) in the established rat model of NEC.MethodsRat pups delivered 1 d prior to term gestation were assigned to one of three groups: dam fed (DF), formula fed (FF), or fed with formula supplemented with 5 × 10(6) CFU B. infantis per day (FF+Binf). Experimental pups were exposed to hypoxia and cold stress. Ileal tissue was examined for pathology and expression of inflammatory mediators, antimicrobial peptides, and goblet-cell products. Ceca were assessed for bacterial composition by analysis of the 16S rRNA sequence.ResultsAdministration of B. infantis significantly reduced the incidence of NEC, decreased expression of Il6, Cxcl1, Tnfa, Il23, and iNOS, and decreased expression of the antimicrobial peptides Reg3b and Reg3g. There was significant microbial heterogeneity both within groups and between experiments. The cecal microbiota was not significantly different between the FF and FF+Binf groups. Bifidobacteria were not detected in the cecum in significant numbers.ConclusionIn the rat model, the inflammation associated with NEC was attenuated by administration of probiotic B. infantis. Dysbiosis was highly variable, precluding determination of the precise role of the microbiota in experimental NEC
Synteny analysis in Rosids with a walnut physical map reveals slow genome evolution in long-lived woody perennials.
BackgroundMutations often accompany DNA replication. Since there may be fewer cell cycles per year in the germlines of long-lived than short-lived angiosperms, the genomes of long-lived angiosperms may be diverging more slowly than those of short-lived angiosperms. Here we test this hypothesis.ResultsWe first constructed a genetic map for walnut, a woody perennial. All linkage groups were short, and recombination rates were greatly reduced in the centromeric regions. We then used the genetic map to construct a walnut bacterial artificial chromosome (BAC) clone-based physical map, which contained 15,203 exonic BAC-end sequences, and quantified with it synteny between the walnut genome and genomes of three long-lived woody perennials, Vitis vinifera, Populus trichocarpa, and Malus domestica, and three short-lived herbs, Cucumis sativus, Medicago truncatula, and Fragaria vesca. Each measure of synteny we used showed that the genomes of woody perennials were less diverged from the walnut genome than those of herbs. We also estimated the nucleotide substitution rate at silent codon positions in the walnut lineage. It was one-fifth and one-sixth of published nucleotide substitution rates in the Medicago and Arabidopsis lineages, respectively. We uncovered a whole-genome duplication in the walnut lineage, dated it to the neighborhood of the Cretaceous-Tertiary boundary, and allocated the 16 walnut chromosomes into eight homoeologous pairs. We pointed out that during polyploidy-dysploidy cycles, the dominant tendency is to reduce the chromosome number.ConclusionSlow rates of nucleotide substitution are accompanied by slow rates of synteny erosion during genome divergence in woody perennials
Where are the Uranus Trojans?
The area of stable motion for fictitious Trojan asteroids around Uranus'
equilateral equilibrium points is investigated with respect to the inclination
of the asteroid's orbit to determine the size of the regions and their shape.
For this task we used the results of extensive numerical integrations of orbits
for a grid of initial conditions around the points L4 and L5, and analyzed the
stability of the individual orbits. Our basic dynamical model was the Outer
Solar System (Jupiter, Saturn, Uranus and Neptune). We integrated the equations
of motion of fictitious Trojans in the vicinity of the stable equilibrium
points for selected orbits up to the age of the Solar system of 5 billion
years. One experiment has been undertaken for cuts through the Lagrange points
for fixed values of the inclinations, while the semimajor axes were varied. The
extension of the stable region with respect to the initial semimajor axis lies
between 19.05 < a < 19.3 AU but depends on the initial inclination. In another
run the inclination of the asteroids' orbit was varied in the range 0 < i < 60
and the semimajor axes were fixed. It turned out that only four 'windows' of
stable orbits survive: these are the orbits for the initial inclinations 0 < i
< 7, 9 < i < 13, 31 < i < 36 and 38 < i < 50. We postulate the existence of at
least some Trojans around the Uranus Lagrange points for the stability window
at small and also high inclinations.Comment: 15 pages, 12 figures, submitted to CMD
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