59 research outputs found
Place of nature in economic development
In the presence of externalities involving nature's services, individuals and communities overexploit natural capital. In other words ecological services are subsidized. This working paper proposes a mathematical model that factors in values of social and environmental costs/benefits. Nature consists of degradable resources: resource stocks are self-regenerative, but suffer from depletion or deterioration when they are over-used. Extreme poverty is frequently associated with a degraded environment. Studies confirm that the world's poorest people live in especially fragile natural environments. When policies are evaluated a social cost-benefit analysis must be included
Realizations of Real Low-Dimensional Lie Algebras
Using a new powerful technique based on the notion of megaideal, we construct
a complete set of inequivalent realizations of real Lie algebras of dimension
no greater than four in vector fields on a space of an arbitrary (finite)
number of variables. Our classification amends and essentially generalizes
earlier works on the subject.
Known results on classification of low-dimensional real Lie algebras, their
automorphisms, differentiations, ideals, subalgebras and realizations are
reviewed.Comment: LaTeX2e, 39 pages. Essentially exetended version. Misprints in
Appendix are correcte
Current approaches to quality assessment, non-clinical and clinical studies of dendritic cell vaccines in oncology
At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness of these cellular immunotherapy methods is evaluated in the context of clinical and biological tumour characteristics and the state of the immune system of a particular patient. One of the immunotherapy options for cancer is the development of autologous dendritic cell vaccines.The aim of this study was to analyse current methodological approaches to the evaluation of the quality, efficacy, and safety of dendritic cell cancer vaccines.This review describes the functional role of dendritic cells in immune response regulation. The paper presents the results of literature analysis covering current approaches to obtaining dendritic cell vaccines with specific characteristics, quality assessment, studies of the anti-tumour efficacy of cell therapy products, and the experience of conducting non-clinical and clinical studies. The review highlights specific aspects of international experience in the registration and clinical use of cell therapy products. The authors discuss methodological approaches to non-clinical studies of dendritic cell vaccines, which should aim to obtain information to select the dose, route, and mode of administration and to identify immunological markers correlating to the clinical efficacy of cell therapy products. The paper covers international experience in conducting clinical trials of dendritic cell vaccines for various malignant neoplasms. The authors propose a list of quality attributes of human somatic cell-based medicinal products for further clinical use
New Bacillus subtilis Strains as Promising Probiotics
Β© 2018, Pleiades Publishing, Ltd. The properties of new B. subtilis strains GM2 and GM5, isolated from potato rhizosphere and possessing high antimicrobial activity, were studied. The potential of the strains for their use as probiotics was characterized. The strains were resistant to bile and to a wide range of the ambient pH. B. subtilis strains GM2 and GM5 possessed proteolytic and phytate-hydrolyzing activity and proved to be safe for model animals. The strains were characterized by antagonistic properties against phytopathogenic micromycetes, as well as against pathogenic and opportunistic enterobacteria. B. subtilis GM2 and GM5 were concluded to be promising strains for use as probiotics
ΠΠΠ‘ΠΠΠΠΠΠΠΠΠ― ΠΠΠ§ΠΠ« ΠΠ Π―ΠΠ¦Π ΠΠΠΠ¬ΠΠΠΠ’ΠΠ
The method of research of tests of the soil on eggs of helminths which sur- passes the method of Romanenko offered earlier in the efficiency is offered and can be used in practice and when carrying out scientific researches. This method was applied to inspection of objects of environment of Kazan city and allowed to reveal big impurity eggs of geohelminths. The developed method allowed to reveal in addition about 36 % of eggs of ascarids than on Romanenko's method that is caused by application of several components in flotation liquid: solutions of chlo- ride of zinc and sodium chloride and glycerin. Components of the flotation liquid don't break morphology of eggs of parasites and don't create difficulties with mor- phological identification of the helminthsΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ± ΠΏΠΎΡΠ²Ρ Π½Π° ΡΠΉΡΠ° Π³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄ΠΈΡ ΠΏΠΎ ΡΠ²ΠΎΠ΅ΠΉ ΡΡ- ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠΉ ΡΠ°Π½Π΅Π΅ ΠΌΠ΅ΡΠΎΠ΄ Π ΠΎΠΌΠ°Π½Π΅Π½ΠΊΠΎ ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π½Π° ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΈ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅- Π½ΠΈΠΈ Π½Π°ΡΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠ°Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π±ΡΠ» ΠΏΡΠΈ- ΠΌΠ΅Π½Π΅Π½ Π΄Π»Ρ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΡΠ΅Π΄Ρ Π³ΠΎ- ΡΠΎΠ΄Π° ΠΠ°Π·Π°Π½ΠΈ ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» Π²ΡΡΠ²ΠΈΡΡ Π±ΠΎΠ»ΡΡΡΡ Π·Π°Π³ΡΡΠ·Π½Π΅Π½- Π½ΠΎΡΡΡ ΡΠΉΡΠ°ΠΌΠΈ Π³Π΅ΠΎΠ³Π΅Π»ΡΠΌΠΈΠ½ΡΠΎΠ². Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²ΡΡΠ²ΠΈΡΡ ΠΏΡΠΈΠ±Π»ΠΈΠ·ΠΈΡΠ΅Π»ΡΠ½ΠΎ 36 % ΡΠΈΡ Π°ΡΠΊΠ°ΡΠΈΠ΄, ΡΠ΅ΠΌ ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄Ρ Π ΠΎΠΌΠ°Π½Π΅Π½ΠΊΠΎ, ΡΡΠΎ ΠΎΠ±Ρ- ΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΡΠ»ΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ: ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² Ρ
Π»ΠΎΡΠΈΠ΄Π° ΡΠΈΠ½ΠΊΠ°, Ρ
Π»ΠΎΡΠΈΠ΄Π° Π½Π°ΡΡΠΈΡ ΠΈ Π³Π»ΠΈΡΠ΅ΡΠΈΠ½Π°. ΠΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅- ΠΌΠΎΠΉ ΡΠ»ΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π΅ Π½Π°ΡΡΡΠ°ΡΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ ΡΠΈΡ ΠΏΠ°ΡΠ°Π·ΠΈΡΠΎΠ² ΠΈ Π½Π΅ ΡΠΎΠ·Π΄Π°ΡΡ Π·Π°ΡΡΡΠ΄Π½Π΅Π½ΠΈΠΉ Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈ- ΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»
Computation of Invariants of Lie Algebras by Means of Moving Frames
A new purely algebraic algorithm is presented for computation of invariants
(generalized Casimir operators) of Lie algebras. It uses the Cartan's method of
moving frames and the knowledge of the group of inner automorphisms of each Lie
algebra. The algorithm is applied, in particular, to computation of invariants
of real low-dimensional Lie algebras. A number of examples are calculated to
illustrate its effectiveness and to make a comparison with the same cases in
the literature. Bases of invariants of the real solvable Lie algebras up to
dimension five, the real six-dimensional nilpotent Lie algebras and the real
six-dimensional solvable Lie algebras with four-dimensional nilradicals are
newly calculated and listed in tables.Comment: 17 pages, extended versio
Draft genome sequence data of Lysinibacillus fusiformis strain GM, isolated from potato phyllosphere as a potential probiotic
Β© 2018 The Authors Here we present the morphological and physiological properties of isolated Lysinibacillus fusiformis strain GM, its draft genome sequence as well as annotation and analysis of its genome. Initial analysis of MALDI-TOF mass spectrometry, 16S rRNA gene analysis and in silico DNA-DNA hybridization revealed that the strain belongs to the species Lysinibacillus fusiformis. The 4,678,122 bp draft genome consist of 17 scaffolds encoding 4588 proteins and 137 RNAs. Annotation of the genome sequence revealed cellulase and protease encoding genes, genes of adhesion proteins and putative genes responsible for the biosynthesis of antimicrobial metabolites. The Whole Genome Shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession number NTMQ00000000.1 (https://www.ncbi.nlm.nih.gov/nuccore/NZ_NTMQ00000000.1)
Block Copolymers of Ethylene Oxide andΒ Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia
Block copolymers of ethylene oxide and propylene oxide (EO/PO block copolymers) are polymeric non-ionic surfactants with a high hydrophilicβlipophilic balance also referred to as pluronics, poloxamers, or proxanols. These compounds are among the most demanded modern excipients for the production of medicines. EO/PO block copolymers are used both in the production of traditional (liquid, semi-solid, and solid) dosage forms and as part of targeted delivery systems. The extensive application of EO/PO block copolymers is due to the diverse array of their properties, including not only solubilising, emulsifying, gelling, and other effects but also thermoreversibility, which is essential for developing in situ delivery systems and 3D printing technologies.The aim of the study was to evaluate the potential of EO/PO block copolymers for medicinal use and to assess the range of medicinal products approved in the Russian Federation that contain EO/PO block copolymers.This review presents an analysis of the register of poloxamer-containing medicines approved in the Russian Federation, a list of the largest manufacturers of EO/PO block copolymers in the world, and a study of the possibility to use copolymers for medical purposes. Currently, there are more than 10 chemical manufacturers producing EO/PO block copolymers for the pharmaceutical, biotechnology, and other industries around the world. EO/PO block copolymers are included in more than 60 medicinal products present in the Russian pharmaceutical market; this observation indicates the need to phase out the import of poloxamers
CΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Ρ ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ Π²Π°ΠΊΡΠΈΠ½ Π² ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ
At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness of these cellular immunotherapy methods is evaluated in the context of clinical and biological tumour characteristics and the state of the immune system of a particular patient. One of the immunotherapy options for cancer is the development of autologous dendritic cell vaccines.The aim of this study was to analyse current methodological approaches to the evaluation of the quality, efficacy, and safety of dendritic cell cancer vaccines.This review describes the functional role of dendritic cells in immune response regulation. The paper presents the results of literature analysis covering current approaches to obtaining dendritic cell vaccines with specific characteristics, quality assessment, studies of the anti-tumour efficacy of cell therapy products, and the experience of conducting non-clinical and clinical studies. The review highlights specific aspects of international experience in the registration and clinical use of cell therapy products. The authors discuss methodological approaches to non-clinical studies of dendritic cell vaccines, which should aim to obtain information to select the dose, route, and mode of administration and to identify immunological markers correlating to the clinical efficacy of cell therapy products. The paper covers international experience in conducting clinical trials of dendritic cell vaccines for various malignant neoplasms. The authors propose a list of quality attributes of human somatic cell-based medicinal products for further clinical use.ΠΠ° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ, Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡΠ΅Π½ΠΈΠ²Π°Π΅ΡΡΡ Π² ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Π²Π°ΠΊΡΠΈΠ½ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β Π°Π½Π°Π»ΠΈΠ· ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°, ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Π²Π°ΠΊΡΠΈΠ½ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΎΠ»ΠΈ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°ΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π²Π°ΠΊΡΠΈΠ½ Ρ Π·Π°Π΄Π°Π½Π½ΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ, ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°, ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΡΠ²Π΅ΡΠ΅Π½Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π²Π°ΠΊΡΠΈΠ½, ΠΊΠΎΡΠΎΡΡΠ΅ Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½Ρ Π½Π° ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΠΉ Π΄Π»Ρ Π²ΡΠ±ΠΎΡΠ° Π΄ΠΎΠ·Ρ, ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ, ΡΠ΅ΠΆΠΈΠΌΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡΠΈΡ
Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΠΉ ΠΎΠΏΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π²Π°ΠΊΡΠΈΠ½ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΡ
. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ ΠΏΠ΅ΡΠ΅ΡΠ΅Π½Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π΄Π»Ρ ΠΈΡ
Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅
Laboratory, numerical and field assessment of the effectiveness of cyclic geomechanical treatment on a tournaisian carbonate reservoir
Results are discussed for evaluation of effectiveness of the cyclic geomechanical treatment (CGT) on a Tournaisian carbonate reservoir. Analysis of laboratory experiments performed according to a special program to assess permeability changes for Tournaisian samples under cyclic changes in pore pressure is presented. The main conclusion is the positive selectivity of the CGT: an increase in permeability is observed for samples saturated with hydrocarbons (kerosene) with connate water, and maximal effect is related to the tightest samples. For water-saturated samples, the permeability decreases after the CGT. Thus, the CGT improves the drainage conditions for tight oil-saturated intervals. It is also confirmed that the CGT reduces the fracturing pressure in carbonate reservoirs. Using flow simulations on detailed sector models taking into account the results of laboratory experiments, a possible increase in well productivity index after CGT with different amplitudes of pressure variation was estimated. Results of a pilot CGT study on a well operating a Tournaisian carbonate reservoir are presented, including the interpretation of production logging and well testing. The increase in the well productivity index is estimated at 44-49Β % for liquid and at 21-26Β % for oil, with a more uniform inflow profile after the treatment. The results of the field experiment confirm the conclusions about the mechanisms and features of the CGT obtained from laboratory studies and flow simulations
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