559 research outputs found
A Model for the Sources of the Slow Solar Wind
Models for the origin of the slow solar wind must account for two seemingly
contradictory observations: The slow wind has the composition of the closed
field corona, implying that it originates from the continuous opening and
closing of flux at the boundary between open and closed field. On the other
hand, the slow wind also has large angular width, up to ~ 60{\circ}, suggesting
that its source extends far from the open-closed boundary. We propose a model
that can explain both observations. The key idea is that the source of the slow
wind at the Sun is a network of narrow (possibly singular) open-field corridors
that map to a web of separatrices and quasi-separatrix layers in the
heliosphere. We compute analytically the topology of an open-field corridor and
show that it produces a quasi-separatrix layer in the heliosphere that extends
to angles far from the heliospheric current sheet. We then use an MHD code and
MDI/SOHO observations of the photospheric magnetic field to calculate
numerically, with high spatial resolution, the quasi-steady solar wind and
magnetic field for a time period preceding the August 1, 2008 total solar
eclipse. Our numerical results imply that, at least for this time period, a web
of separatrices (which we term an S-web) forms with sufficient density and
extent in the heliosphere to account for the observed properties of the slow
wind. We discuss the implications of our S-web model for the structure and
dynamics of the corona and heliosphere, and propose further tests of the model
High resolution climate projection of storm surge at the Venetian coast
Abstract. Climate change impact on storm surge regime is of great importance for the safety and maintenance of Venice. In this study a future storm surge scenario is evaluated using new high resolution sea level pressure and wind data recently produced by EC-Earth, an Earth System Model based on the operational seasonal forecast system of the European Centre for Medium-Range Weather Forecasts (ECMWF). The study considers an ensemble of six 5 yr long simulations of the rcp45 scenario at 0.25° resolution and compares the 2094–2098 to the 2004–2008 period. EC-Earth sea level pressure and surface wind fields are used as input for a shallow water hydrodynamic model (HYPSE) which computes sea level and barotropic currents in the Adriatic Sea. Results show that a high resolution climate model is needed for producing realistic values of storm surge statistics and confirm previous studies in that they show little sensitivity of storm surge levels to climate change. However, some climate change signals are detected, such as increased persistence of high pressure conditions, an increased frequency of windless hour, and a decreased number of moderate windstorms
A higher Angiogenin expression is associated with a non-nuclear Maspin location in laryngeal carcinoma
Objectives. In numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).
Methods. Immunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.
Results. On univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression 655.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression 655.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).
Conclusion. Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC
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