The heating of the thermal plasma with energetic electrons in small solar flares

The energetic electrons deduced from hard X-rays in the thick target model may be responsible for heating of soft X-ray plasma in solar flares. It is shown from OSO-7 studies that if a cutoff of 10 keV is assumed, the total electron is comparable to the thermal plasma energy. However, (1) the soft X-ray emission often appears to begin before the hard X-ray burst, (2) in about one-third of flares there is no detectable hard X-ray emission, and (3) for most events the energy content (assuming constant density) of soft X-ray plasma continues to rise after the end of the hard X-ray burst. To understand these problems we have analyzed the temporal relationship between soft X-rays and hard X-rays for 20 small events observed by ISEE-3 during 1980. One example is shown. The start of soft X-ray and hard X-ray bursts is defined as the time when the counting rates of the 4.8 to 5. keV and 25.8 to 43.2 keV channels, respectively, exceed the background by one standard deviation

Momentum distribution, vibrational dynamics and the potential of mean force in ice

By analyzing the momentum distribution obtained from path integral and phonon calculations we find that the protons in hexagonal ice experience an anisotropic quasi-harmonic effective potential with three distinct principal frequencies that reflect molecular orientation. Due to the importance of anisotropy, anharmonic features of the environment cannot be extracted from existing experimental distributions that involve the spherical average. The full directional distribution is required, and we give a theoretical prediction for this quantity that could be verified in future experiments. Within the quasi-harmonic context, anharmonicity in the ground state dynamics of the proton is substantial and has quantal origin, a finding that impacts the interpretation of several spectroscopies

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A)

BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available. Antagonists of the angiotensin II receptor type 1 (AT1), including the anti-hypertensive drug losartan, have been shown to block also the profibrotic action of transforming growth factor (TGF)-beta and thereby ameliorate disease progression in mouse models of Marfan syndrome. Because fibrosis and failure of muscle regeneration are the main reasons for the severe disease course of MDC1A, we tested whether L-158809, an analog derivative of losartan, could ameliorate the dystrophy in dyW/dyW mice, the best-characterized model of MDC1A. METHODS: L-158809 was given in food to dyW/dyW mice at the age of 3 weeks, and the mice were analyzed at the age of 6 to 7 weeks. We examined the effect of L-158809 on muscle histology and on muscle regeneration after injury as well as the locomotor activity and muscle strength of the mice. RESULTS: We found that TGF-beta signaling in the muscles of the dyW/dyW mice was strongly increased, and that L-158809 treatment suppressed this signaling. Consequently, L-158809 reduced fibrosis and inflammation in skeletal muscle of dyW/dyW mice, and largely restored muscle regeneration after toxin-induced injury. Mice showed improvement in their locomotor activity and grip strength, and their body weight was significantly increased. CONCLUSION: These data provide evidence that AT1 antagonists ameliorate several hallmarks of MDC1A in dyW/dyW mice, the best-characterized mouse model for this disease. Because AT1 antagonists are well tolerated in humans and widely used in clinical practice, these results suggest that losartan may offer a potential future treatment of patients with MDC1A

Renormalization Group and Asymptotics of Solutions of Nonlinear Parabolic Equations

We present a general method for studying long time asymptotics of nonlinear parabolic partial differential equations. The method does not rely on a priori estimates such as the maximum principle. It applies to systems of coupled equations, to boundary conditions at infinity creating a front, and to higher (possibly fractional) differential linear terms. We present in detail the analysis for nonlinear diffusion-type equations with initial data falling off at infinity and also for data interpolating between two different stationary solutions at infinity.Comment: 29 page