11 research outputs found
Curved Noncommutative Tori as Leibniz Quantum Compact Metric Spaces
We prove that curved noncommutative tori, introduced by Dabrowski and Sitarz,
are Leibniz quantum compact metric spaces and that they form a continuous
family over the group of invertible matrices with entries in the commutant of
the quantum tori in the regular representation, when this group is endowed with
a natural length function.Comment: 16 Pages, v3: accepted in Journal of Math. Physic
Connes distance by examples: Homothetic spectral metric spaces
We study metric properties stemming from the Connes spectral distance on
three types of non compact noncommutative spaces which have received attention
recently from various viewpoints in the physics literature. These are the
noncommutative Moyal plane, a family of harmonic Moyal spectral triples for
which the Dirac operator squares to the harmonic oscillator Hamiltonian and a
family of spectral triples with Dirac operator related to the Landau operator.
We show that these triples are homothetic spectral metric spaces, having an
infinite number of distinct pathwise connected components. The homothetic
factors linking the distances are related to determinants of effective Clifford
metrics. We obtain as a by product new examples of explicit spectral distance
formulas. The results are discussed.Comment: 23 pages. Misprints corrected, references updated, one remark added
at the end of the section 3. To appear in Review in Mathematical Physic
Ensuring transparency and minimization of methodologic bias in preclinical pain research:PPRECISE considerations
Acknowledgements The authors thank Allison Lin, Dan Mellon, and LiSheng Chen for their help throughout the process of writing this article.Peer reviewedPublisher PD
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
Abstract There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration sponsored a consensus meeting of the Preclinical Pain Research Consortium for Investigating Safety and Efficacy (PPRECISE) Working Group. International participants from universities, funding agencies, government agencies, industry, and a patient advocacy organization attended. Reduction of publication bias, increasing the ability of others to faithfully repeat experimental methods, and increased transparency of data reporting were specifically discussed. Parameters deemed essential to increase confidence in the published literature were clear, specific reporting of an a priori hypothesis and definition of primary outcome measure. Power calculations and whether measurement of minimal meaningful effect size to determine these should be a core component of the preclinical research effort provoked considerable discussion, with many but not all agreeing. Greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders. The conduct of high-quality science that is fully reported should not preclude novelty and innovation in preclinical pain research, and indeed, any efforts that curtail such innovation would be misguided. We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues
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Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.
There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration sponsored a consensus meeting of the Preclinical Pain Research Consortium for Investigating Safety and Efficacy (PPRECISE) Working Group. International participants from universities, funding agencies, government agencies, industry, and a patient advocacy organization attended. Reduction of publication bias, increasing the ability of others to faithfully repeat experimental methods, and increased transparency of data reporting were specifically discussed. Parameters deemed essential to increase confidence in the published literature were clear, specific reporting of an a priori hypothesis and definition of primary outcome measure. Power calculations and whether measurement of minimal meaningful effect size to determine these should be a core component of the preclinical research effort provoked considerable discussion, with many but not all agreeing. Greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders. The conduct of high-quality science that is fully reported should not preclude novelty and innovation in preclinical pain research, and indeed, any efforts that curtail such innovation would be misguided. We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues