A continuous isotropic-nematic liquid crystalline transition of F-actin solutions

The phase transition from the isotropic (I) to nematic (N) liquid crystalline suspension of F-actin of average length $3~\mu$m or above was studied by local measurements of optical birefringence and protein concentration. Both parameters were detected to be continuous in the transition region, suggesting that the I-N transition is higher than 1st order. This finding is consistent with a recent theory by Lammert, Rokhsar & Toner (PRL, 1993, 70:1650), predicting that the I-N transition may become continuous due to suppression of disclinations. Indeed, few line defects occur in the aligned phase of F-actin. Individual filaments in solutions of a few mg/ml F-actin undergo fast translational diffusion along the filament axis, whereas both lateral and rotational diffusions are suppressed.Comment: 4 pages with 4 figures. Submitted to Physical Review Letter

Topological Phases in Graphitic Cones

The electronic structure of graphitic cones exhibits distinctive topological features associated with the apical disclinations. Aharonov-Bohm magnetoconductance oscillations (period Phi_0) are completely absent in rings fabricated from cones with a single pentagonal disclination. Close to the apex, the local density of states changes qualitatively, either developing a cusp which drops to zero at the Fermi energy, or forming a region of nonzero density across the Fermi energy, a local metalization of graphene.Comment: 4 pages, RevTeX 4, 3 PostScript figure

Contributions to the mixed-alkali effect in molecular dynamics simulations of alkali silicate glasses

The mixed-alkali effect on the cation dynamics in silicate glasses is analyzed via molecular dynamics simulations. Observations suggest a description of the dynamics in terms of stable sites mostly specific to one ionic species. As main contributions to the mixed--alkali slowdown longer residence times and an increased probability of correlated backjumps are identified. The slowdown is related to the limited accessibility of foreign sites. The mismatch experienced in a foreign site is stronger and more retarding for the larger ions, the smaller ions can be temporarily accommodated. Also correlations between unlike as well as like cations are demonstrated that support cooperative behavior.Comment: 10 pages, 12 figures, 1 table, revtex4, submitted to Phys. Rev.

Hepatic consequences of COVID-19 infection. Lapping or biting?

The outbreak of coronavirus disease 2019 (COVID-19) starting last December in China placed emphasis on liver involvement during infection. This review discusses the underlying mechanisms linking COVID-19 to liver dysfunction, according to recent available information, while waiting further studies. The manifestations of liver damage are usually mild (moderately elevated serum aspartate aminotransferase activities), and generally asymptomatic. Few patients can still develop severe liver problems, and therapeutic options can be limited. Liver dysfunction may affect about one-third of the patients, with prevalence greater in men than women, and in elderly. Mechanisms of damage are complex and include direct cholangiocyte damage and other coexisting conditions such as the use of antiviral drugs, systemic inflammatory response, respiratory distress syndrome-induced hypoxia, sepsis, and multiple organ dysfunction. During new COVID-19 infections, liver injury may be observed. If liver involvement appears during COVID-19 infection, however, attention is required. This is particularly true if patients are older or have a pre-existing history of liver diseases. During COVID-19 infection, the onset of liver damage impairs the prognosis, and hospital stay is longer

Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles

In-use and laboratory-derived fuel economies were analyzed for a medium-duty hybrid electric drivetrain with 'engine off at idle' capability and a conventional drivetrain in a typical commercial package delivery application. Vehicles studied included eleven 2010 Freightliner P100H hybrids in service at a United Parcel Service facility in Minneapolis during the first half of 2010. The hybrids were evaluated for 18 months against eleven 2010 Freightliner P100D diesels at the same facility. Both vehicle groups use the same 2009 Cummins ISB 200-HP engine. In-use fuel economy was evaluated using UPS's fueling and mileage records, periodic ECM image downloads, and J1939 CAN bus recordings during the periods of duty cycle study. Analysis of the in-use fuel economy showed 13%-29% hybrid advantage depending on measurement method, and a delivery route assignment analysis showed 13%-26% hybrid advantage on the less kinetically intense original diesel route assignments and 20%-33% hybrid advantage on the more kinetically intense original hybrid route assignments. Three standardized laboratory drive cycles were selected that encompassed the range of real-world in-use data. The hybrid vehicle demonstrated improvements in ton-mi./gal fuel economy of 39%, 45%, and 21% on the NYC Comp, HTUF Class 4, and CARB HHDDT test cycles, respectively

Mixing layer height derived from radiosoundings and ground-based lidar - comparison and assessment

The inversion on top of the atmospheric boundary layer is a strong barrier for the transport of heat, momentum and matter from or to the earth's surface. Regarding aerosols and gaseous constituents like water vapour which originate from the surface, the concentration of those parameters within the boundary layer strongly depends on the height of the layer, the mixing height. During daytime the mixing height over land increases and reaches a maximum value in situations with constant synoptic conditions. In many applications, e.g. the comparison of model output with observations the mixing height is taken from radiosoundings. Often this value is - due to lack of other measurements - also taken as the height of the fully developed convective boundary layer. Since the mixing height is strongly varying both in time and space an observation along a single line like a radiosonde track represents only an estimate of the mixing height. Quasi-continuous measurements of the backscatter signal with a ground-based lidar from several field campains offer the opportunity to estimate the error associated with a mixing-height determination from radiosoundings. A method to determine the mixing height from the backscattered signal is presented. Data from several field campaigns are used, namely the Nauru99 campaign in the tropical western Pacific in June/July 1999, three campaigns at the ARM-site in Oklahoma (USA) in September/October 1999, September/October 2000 and November/December 2000 and three campaigns in the frame of the German EVA-GRIPS (Regional Evaporation at Grid/Pixel Scale) project near Lindenberg (Brandenburg, Germany) in September 2002, April 2003 and May/June 2003 (LITFASS-2003). From these campaigns measurements simultaneous to approximatly 50 radiosoundings exist and allow a statistical analysis of the results. The comparison of radiosonde mixing heights with lidar mixing heights over 10 min time intervalls reveal a good agreement, the better the shorter the distance between radiosonde launch point and lidar location. Lidar mixing heights averaged over 1 h, which are more representative for an area, may deviate up to 300 m from radiosonde mixing heights. The standard deviation within the averaging interval fairly represents the variability of the mixing layer height. The maximum mixing height which is given by an afternoon radiosounding is also compared with lidar measurements