THE TRAINING OF AUTO MECHANICS WITH THE USE OF AUTOMATED TRAINING SYSTEM «MAINTENANCE AND REPAIR AVTODELO»

The article considers a solution to the problem of training in the field of maintenance of vehicles using the automated training system “Maintenance and repair “Avtodelo””. The advantages of the educational organization developed according to the requirements of the automated training system for the training of car mechanics are presentedРассмотрен вариант решения проблемы подготовки кадров в сфере обслуживания автотранспорта с использованием автоматизированной обучающей системы «Техническое обслуживание и ремонт “Автодело”». Представлены преимущества разработанной по требованиям образовательной организации автоматизированной обучающей системы для обучения автомехаников

Genetic variation of RFXANK gene in Stavropol sheep breed

Using of NimbleGen sequencing technology for detection of polymorphisms RFXANK gene in Stavropolsheep breed, we found 20 SNPs. That is, two SNP in exons - c.63C>A (non synonymous) in exon II and c.498G>A in exon VI (synonymous). Others SNP is in introns: c.-343T>C, c.- 111T>G, c.187+328G>A, c.338-94G>A, c.632–124G>A, c.713-82G>A, c.187+62G>A, c.188-588G>C, c.188- 127C>T, c.565-44A>G, c.712+309C>T, c.712+354C>T, c.712+309C>T, c.187+394C>T, c.187+469A>G, c.187+71G>C, c.188-670A>G, c.713-107G>T. Some of them are presented together

The Role of Lipid Peroxidation Products and Antioxidant Enzymes in the Pathogenesis of Aseptic and Purulent Inflammation in Cats

Objective: The work aimed to determine the state of lipid peroxidation products and the activity of the antioxidant system in cats with aseptic inflammation and purulent-inflammatory processes of varying severity. Materials and Methods: The intensity of the process of lipid peroxidation- antioxidant system processes in blood plasma was evaluated using commercial kits. The level of diene conjugates (DC), the content of malondialdehyde (MDA), the level of medium-weight molecules were deter- mined from lipid peroxidation indices. The state of antioxidant protection was assessed by indi- cators of superoxide dismutase (SOD) activity, catalase (CT), ceruloplasmin (CP) concentration, glutathione peroxidase activity, glutathione reductase (GLR), and total antioxidant activity (AOA). Results: With aseptic inflammation in the blood of cats, a slow activation of peroxidation reactions occurred. The DC indicator increased by 1.4 times, the SOD level rose by 1.38 times, the amount of GLR by 1.04 times, and the activation of total AOA by 9.06. In sepsis, the values of DC, MDA, and medium-weight molecules increased by 4.4, 8.4, and 8.8 times, respectively. With abscesses in the blood of cats, an increase in CT, CP, and GLR is observed against a background of a decrease in glutathione peroxidase. With purulent wounds, the total AOA of plasma increases by 2.5 times; with abscesses, the total AOA increases by 1.9 times, and with sepsis, it decreases by 1.5 times. Conclusion: With surgical infections in cats, deep biochemical changes or irreversible biochemical changes (in sepsis) occur that indicate a significantly enhanced catabolic orientation of metabolic processes and the accumulation of toxic metabolites, which leads to damage and a decrease in tissue regenerative capacity. © The authors. Thisis an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0