Scientific publications of the Bioscience Program Division. Volume II - Environmental biology

Environmental biology bibliography, including citations on biochemistry, radiobiology, and bioinstrumentatio

NASA contract listings of publications under the behavioral biology program

Behavioral biology - bibliograph

The results of the in-flight attitude sensor calibration for the Arthur Holly Compton Gamma Ray Observatory

The Arthur Holly Compton Gamma Ray Observatory (GRO) was launched by the shuttle Atlantis in April 1991. This paper presents the results of the attitude sensor calibration that was performed during the early mission. The GSFC Flight Dynamics Facility (FDF) performed an alignment calibration of the two fixed-head star trackers (FHST's) and two fine Sun sensors (FSS's) on board Compton GRO. The results show a 27-arcsecond shift between the bore sights of the FHST's with respect to prelaunch measurements. The alignments of the two FSS's shifted by 0.20 and 0.05 degree. During the same time period, the Compton GRO science teams performed an alignment calibration of the science instruments with respect to the attitude reported by the on board computer (OBC). In order to preserve these science alignments, FDF adjusted the overall alignments of the FHST's and FSS's, obtained by the FDF calibration, such that when up linked to the OBC, the shift in the OBC-determined attitude is minimized. FDF also calibrated the inertial reference unit (IRU), which consists of three dual-axis gyroscopes. The observed gyro bias matched the bias that was solved for by the OBC. This bias drifted during the first 6 days after release. The results of the FDF calibration of scale factor and alignment shifts showed changes that were of the same order as their uncertainties

Search for Intrinsic Excitations in 152Sm

The 685 keV excitation energy of the first excited 0+ state in 152Sm makes it an attractive candidate to explore expected two-phonon excitations at low energy. Multiple-step Coulomb excitation and inelastic neutron scattering studies of 152Sm are used to probe the E2 collectivity of excited 0+ states in this "soft" nucleus and the results are compared with model predictions. No candidates for two-phonon K=0+ quadrupole vibrational states are found. A 2+, K=2 state with strong E2 decay to the first excited K=0+ band and a probable 3+ band member are established.Comment: 4 pages, 6 figures, accepted for publication as a Rapid Communication in Physical Review

In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a Gram-negative bacterium that represents the main cause of porcine pleuropneumonia in pigs, causing significant economic losses to the livestock industry worldwide. A. pleuropneumoniae, as the majority of Gram-negative bacteria, excrete vesicles from its outer membrane (OM), accordingly defined as outer membrane vesicles (OMVs). Thanks to their antigenic similarity to the OM, OMVs have emerged as a promising tool in vaccinology. In this study we describe the in vivo testing of several vaccine prototypes for the prevention of infection by all known A. pleuropneumoniae serotypes. Previously identified vaccine candidates, the recombinant proteins ApfA and VacJ, administered individually or in various combinations with the OMVs, were employed as vaccination strategies. Our data show that the addition of the OMVs in the vaccine formulations significantly increased the specific IgG titer against both ApfA and VacJ in the immunized animals, confirming the previously postulated potential of the OMVs as adjuvant. Unfortunately, the antibody response raised did not translate into an effective protection against A. pleuropneumoniae infection, as none of the immunized groups following challenge showed a significantly lower degree of lesions than the controls. Interestingly, quite the opposite was true, as the animals with the highest IgG titers were also the ones bearing the most extensive lesions in their lungs. These results shed new light on A. pleuropneumoniae pathogenicity, suggesting that antibody-mediated cytotoxicity from the host immune response may play a central role in the development of the lesions typically associated with A. pleuropneumoniae infections

Interatomic potentials for atomistic simulations of the Ti-Al system

Semi-empirical interatomic potentials have been developed for Al, alpha-Ti, and gamma-TiAl within the embedded atomic method (EAM) by fitting to a large database of experimental as well as ab-initio data. The ab-initio calculations were performed by the linear augmented plane wave (LAPW) method within the density functional theory to obtain the equations of state for a number of crystal structures of the Ti-Al system. Some of the calculated LAPW energies were used for fitting the potentials while others for examining their quality. The potentials correctly predict the equilibrium crystal structures of the phases and accurately reproduce their basic lattice properties. The potentials are applied to calculate the energies of point defects, surfaces, planar faults in the equilibrium structures. Unlike earlier EAM potentials for the Ti-Al system, the proposed potentials provide reasonable description of the lattice thermal expansion, demonstrating their usefulness in the molecular dynamics or Monte Carlo studies at high temperatures. The energy along the tetragonal deformation path (Bain transformation) in gamma-TiAl calculated with the EAM potential is in a fairly good agreement with LAPW calculations. Equilibrium point defect concentrations in gamma-TiAl are studied using the EAM potential. It is found that antisite defects strongly dominate over vacancies at all compositions around stoichiometry, indicating that gamm-TiAl is an antisite disorder compound in agreement with experimental data.Comment: 46 pages, 6 figures (Physical Review B, in press