Study of malignant tumours of the uterine corpus: histopathology and immunohistochemistry

Background: The uterine corpus represents the second most common site for malignancy in the female genital tract. This study was performed to ascertain the profile of malignant tumours of the uterine corpus reported at our centre.Methods: A retrospective analysis of cases retrieved from the archives of the department of pathology from January 2014 to December 2016. Clinical information of the patients was collected from the hospital records.  Classification and grading of the tumours were done according to the current WHO classification.Results: Nineteen cases were studied. There were ten cases of endometrial adenocarcinoma, five cases of leiomyosarcoma, three cases of endometrial stromal sarcoma and one case of carcinosarcoma(malignant mixed mullerian tumour). The age range of endometrial adenocarcinoma was 55 to 85 years and presented with post menopausal bleeding, whereas endometrial stromal sarcomas occurred in women above 45 years of age. Leiomyosarcomas had age range from 26 to 65 years. All leiomyosarcomas were clinically diagnosed as fibroid. Majority of endometrial adenocarcinomas were well differentiated endometroid type. Out of the three endometrial stromal sarcomas two were high grade, one with metastasis. All leiomyosarcomas showed mitotic rate above 10/10hpf.Conclusions: Endometrial carcinomas form the majority of malignant tumours of uterine corpus and occur in older age group followed by leiomyosarcomas. Endometrial stromal sarcomas are less common and occur in middle aged and older patients. Leiomyosarcomas and stromal sarcomas are usually misdiagnosed as fibroids clinically unless metastases are present

Approach for reporting serous effusion fluid in pleural, peritoneal and pericardial cavity and immunohistochemistry

Background: The aim of this study is to make a detailed cytological study of effusion fluids and compare with cell block study of the representative cases and IHC studies were done.Methods: Prospective study of 216 cases effusion fluids from in and around hospitals, Mangalore. This study conducted over a period of 18 months from October-2014 to April-2016. This study scrutinized and approved by Institutional Ethics Committee. The samples were processed by conventional cytology using Papanicolaou-stain and Cell Block (CB) method using 10% Alcohol-formalin fixative and stained with H and E. The cellularity, architectural patterns, morphological details were studied both smears. Ancillary immunohistochemical staining with calretinin and EMA are done.Results: A total of 216 cases of effusion fluids with cell block study were included, age range of 13 years to 93 years. Pleural fluid comprised of 55.09%, peritoneal fluid of 43.51% and pericardial fluid of 1.38%. 71% were clinically diagnosed as non-neoplastic and 29% were neoplastic condition. In CS study, 84.5% cases were benign/reactive effusion and 8.5% were positive for malignancy. In CB study, 84.5% were benign/reactive effusion and 10.2% were positive for malignancy. In comparison authors found an increase in diagnostic efficacy by 18%. IHC EMA for adenocarcinoma cells has sensitivity of 100% and calretinin for reactive mesothelial cells has specificity of 100%.Conclusions: Authors concluded that cell block technique when used as an adjuvant to routine smear examination in effusion fluids has increased the diagnostic yield and better preservation of architectural pattern. IHC is helpful in differentiating between reactive mesothelial and adenocarcinoma cells

An environmental sustainability roadmap for partially substituting agricultural waste for sand in cement blocks

Agricultural waste can be used in cement block production for a number of reasons, including its environmental, economic, and labor benefits. This study examines the mechanical, durability, and cost-effectiveness characteristics of cement blocks. A cement block made from agriculture waste promotes sustainable construction practices, since waste agriculture is often dumped in landfills and regarded as a waste material. Carbon dioxide (CO2) emissions produced by the construction sector, either from the firing of clay bricks or from the production of cement, contribute significantly to global warming. In many developing countries, air pollution from agricultural activities is primarily accounted for the emissions from agricultural machinery and openly burning agro-waste. Farming is one of the leading causes of water and soil pollution. Hence, adopting agricultural waste into cement production would significantly reduce the environmental impact of concrete structures. The goal of this research is to determine whether agricultural waste products, such as vermiculite, pistachio shells, sugarcane bagasse, and coconut husks, can be used to substitute sand in concrete blocks. The water absorption capacity of waste materials, density, flexural strength, fire resistance, and compressive strength of waste materials as admixtures in concrete were evaluated using experimental tests. In most cases, the concrete blocks made from agricultural waste were strong enough to satisfy ASTM standards. The specimens containing coconut husks and pistachio shells, among others, were found to be fairly strong and durable, even when isolating them from water

Inertial impedance of coalescence during collision of liquid drops

The fluid dynamics of the collision and coalescence of liquid drops has intrigued scientists and engineers for more than a century owing to its ubiquitousness in nature, e.g. raindrop coalescence, and industrial applications, e.g. breaking of emulsions in the oil and gas industry. The complexity of the underlying dynamics, which includes occurrence of hydrodynamic singularities, has required study of the problem at different scales – macroscopic, mesoscopic and molecular – using stochastic and deterministic methods. In this work, a multi-scale, deterministic method is adopted to simulate the approach, collision, and eventual coalescence of two drops where the drops as well as the ambient fluid are incompressible, Newtonian fluids. The free boundary problem governing the dynamics consists of the Navier–Stokes system and associated initial and boundary conditions that have been augmented to account for the effects of disjoining pressure as the separation between the drops becomes of the order of a few hundred nanometres. This free boundary problem is solved by a Galerkin finite element-based algorithm. The interplay of inertial, viscous, capillary and van der Waals forces on the coalescence dynamics is investigated. It is shown that, in certain situations, because of inertia two drops that are driven together can first bounce before ultimately coalescing. This bounce delays coalescence and can result in the computed value of the film drainage time departing significantly from that predicted from existing scaling theories

Effect of lead content on the formation of the 2223 phase

Freeze-dried powders have been used for the formation of the high Tc (110 K) superconducting phase in the Bi-Sr-Ca-Cu-O system. Effects of lead content and oxygen partial pressure were investigated. It was shown that lead content and oxygen partial pressure were affecting liquid phase formation. Lead content affected the dissolution of the 2212 phase into the liquid phase from which the 2223 high Tc superconducting phase forms. Powder reacted as pellet with Bi{sub 1.8}Pb{sub 0.4}Sr{sub 2.0}Ca{sub 2.0}Cu{sub 3.0}O{sub x} composition shows essentially phase pure 2223 after 12 hrs at 845{degrees} C in 7%O{sub 2}

Single Axis Semi Automatic Drilling Machine with PLC Control

ABSTRACT:Under conventionally controlled drilling machine the depth controlled cannot be made possible. Due to over drilling the job gets failed. While drilling we cannot measure the drilling depth during drilling process. Hence the semiautomatic drilling machine will automatically control the depth of the job and it of safer mode. In some cases due to over drilling the work bench will gets destroyed or the tool will be damaged. Hence for these conditions our project work had been taken up to get through the new technologies. This made the drilling machine easier. This semiautomatic drilling machine is very well used in mechanical workshops and it made the work easier. It consumes less time and the finishing process will be quite easier, while compared to the conventional drilling machine

Plethora of transitions during breakup of liquid filaments.

Thinning and breakup of liquid filaments are central to dripping of leaky faucets, inkjet drop formation, and raindrop fragmentation. As the filament radius decreases, curvature and capillary pressure, both inversely proportional to radius, increase and fluid is expelled with increasing velocity from the neck. As the neck radius vanishes, the governing equations become singular and the filament breaks. In slightly viscous liquids, thinning initially occurs in an inertial regime where inertial and capillary forces balance. By contrast, in highly viscous liquids, initial thinning occurs in a viscous regime where viscous and capillary forces balance. As the filament thins, viscous forces in the former case and inertial forces in the latter become important, and theory shows that the filament approaches breakup in the final inertial-viscous regime where all three forces balance. However, previous simulations and experiments reveal that transition from an initial to the final regime either occurs at a value of filament radius well below that predicted by theory or is not observed. Here, we perform new simulations and experiments, and show that a thinning filament unexpectedly passes through a number of intermediate transient regimes, thereby delaying onset of the inertial-viscous regime. The new findings have practical implications regarding formation of undesirable satellite droplets and also raise the question as to whether similar dynamical transitions arise in other free-surface flows such as coalescence that also exhibit singularities.The authors thank Dr. Pankaj Doshi for several insightful discussions. This work was supported by the Basic Energy Sciences program of the US Department of Energy (DE-FG02-96ER14641), Procter & Gamble USA, the Chevron Corporation, the UK Engineering and Physical Sciences Research Council (Grant EP/H018913/1), the John Fell Oxford University Press Research Fund, and the Royal Society.This is the final published version. It first appeared via PNAS at http://dx.doi.org/10.1073/pnas.141854111

Successful Recanalization of Chronic Total Occlusions Is Associated With Improved Long-Term Survival

ObjectivesThis study investigated the impact of procedural success on mortality following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a large cohort of patients in the drug-eluting stent era.BackgroundDespite advances in expertise and technologies, many patients with CTO are not offered PCI.MethodsA total of 6,996 patients underwent elective PCI for stable angina at a single center (2003 to 2010), 836 (11.9%) for CTO. All-cause mortality was obtained to 5 years (median: 3.8 years; interquartile range: 2.0 to 5.4 years) and stratified according to successful chronic total occlusion (sCTO) or unsuccessful chronic total occlusion (uCTO) recanalization. Major adverse cardiac events (MACE) included myocardial infarction (MI), urgent revascularization, stroke, or death.ResultsA total of 582 (69.6%) procedures were successful. Stents were implanted in 97.0% of successful procedures (mean: 2.3 ± 0.1 stents per patient, 73% drug-eluting). Prior revascularization was more frequent among uCTO patients: coronary artery bypass grafting (CABG) (16.5% vs. 7.4%; p < 0.0001), PCI (36.0% vs. 21.2%; p < 0.0001). Baseline characteristics were otherwise similar. Intraprocedural complications, including coronary dissection, were more frequent in unsuccessful cases (20.5% vs. 4.9%; p < 0.0001), but did not affect in-hospital MACE (3% vs. 2.1%; p = NS). All-cause mortality was 17.2% for uCTO and 4.5% for sCTO at 5 years (p < 0.0001). The need for CABG was reduced following sCTO (3.1% vs. 22.1%; p < 0.0001). Multivariate analysis demonstrated that procedural success was independently predictive of mortality (hazard ratio [HR]: 0.32 [95% confidence interval (CI): 0.18 to 0.58]), which persisted when incorporating a propensity score (HR: 0.28 [95% CI: 0.15 to 0.52]).ConclusionsSuccessful CTO PCI is associated with improved survival out to 5 years. Adoption of techniques and technologies to improve procedural success may have an impact on prognosis