Crassulacean Acid Metabolism in Three Species of the C4 Genus Portulaca

The putative existence of Crassulacean acid metabolism was investigated in three succulent species of the C4 genus Portulaca: P. grandiflora (a widely cultivated species), P. oleracea (a cosmopolitan weed), and P. mundula (found on rock outcrops throughout the southwestern United States). Patterns of diurnal conductance and CO2 exchange, as well as diurnal tissue malic acid fluctuations, were measured in plants under well-watered and drought-stressed conditions. Net CO2 uptake in both treatments occurred only during the day, although small amounts of nighttime CO2 uptake occurred in a few individuals. Stomatal conductances in well-watered and drought-stressed P. mundula and drought-stressed P. oleracea were higher during the night than during the day, though these higher conductances were generally not accompanied by net CO2 assimilation. No significant diurnal malic acid fluctuations occurred under well-watered conditions in any species; however, under drought stress, significant diurnal malic acid fluctuations occurred in the three species. The primary source of carbon for nocturnal malic acid production is presumed to be respiratory CO2, as occurs in C3 plants that undergo CAM-cycling. This study confirms past reports of CAM acid fluctuations in P. grandiflora and P. oleracea and marks the first report of CAM activity in P. mundul

A Bima Array Survey of Molecules in Comets Linear (C/2002 T7) and Neat (C/2001 Q4)

We present an interferometric search for large molecules, including methanol, methyl cyanide, ethyl cyanide, ethanol, and methyl formate in comets LINEAR (C/2002 T7) and NEAT (C/2001 Q4) with the Berkeley-Illinois-Maryland Association (BIMA) array. In addition, we also searched for transitions of the simpler molecules CS, SiO, HNC, HN13C and 13CO . We detected transitions of methanol and CS around Comet LINEAR and one transition of methanol around Comet NEAT within a synthesized beam of ~20''. We calculated the total column density and production rate of each molecular species using the variable temperature and outflow velocity (VTOV) model described by Friedel et al.(2005).Considering the molecular production rate ratios with respect to water, Comet T7 LINEAR is more similar to Comet Hale-Bopp while Comet Q4 NEAT is more similar to Comet Hyakutake. It is unclear, however, due to such a small sample size, whether there is a clear distinction between a Hale-Bopp and Hyakutake class of comet or whether comets have a continuous range of molecular production rate ratios.Comment: Accepted for Publication in the Astrophysical Journa

Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

© 2018 John M. Kane III et al. Background. Sarcoma mortality remains high despite adjuvant chemotherapy. Biomarker predictors of treatment response and outcome could improve treatment selection. Methods. Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation. Biomarkers were measured using automated computerized imaging (AQUA or ACIS). Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS). Results. Specimens from 60 patients included 23 pretreatment (PRE), 40 posttreatment (POST), and 12 matched pairs (MPs). In the MP set, CAIX, GLUT1, and PARP1 expression significantly decreased following neoadjuvant therapy, but p53 nuclear/cytoplasmic (N/C) ratio increased. In the PRE set, no biomarker expression was associated with DFS, DDFS, or OS. In the POST set, increased p53 N/C ratio was associated with a significantly decreased DFS and DDFS (HR 4.13, p=0.017; HR 4.16, p=0.016), while increased ERCC1 and XPF expression were associated with an improved DFS and DDFS. No POST biomarkers were associated with OS. Conclusions. PRE biomarker expression did not predict survival outcomes. Expression pattern changes after neoadjuvant chemoradiation supports the concepts of tumor reoxygenation, altered HIF-1α signaling, and a p53 nuclear accumulation DNA damage response. Clinical Trial Registration. NRG Oncology RTOG 9514 is registered with ClinicalTrials.gov. The ClinicalTrials.gov Identifier is NCT00002791

The Medium Is the Danger: Discourse about Television among Amish and Ultra-Orthodox (Haredi) Women

This study shows how Old Order Amish and ultra-Orthodox women’s discourse about television can help develop a better understanding of the creation, construction, and strengthening of limits and boundaries separating enclave cultures from the world. Based on questionnaires containing both closed- and open-ended questions completed by 82 participants, approximately half from each community, I argue that both communities can be understood as interpretive communities that negatively interpret not only television content, like other religious communities, but also the medium itself. Their various negative interpretive strategies is discussed and the article shows how they are part of an “us-versus-them” attitude created to mark the boundaries and walls that enclave cultures build around themselves. The comparison between the two communities found only a few small differences but one marked similarity: The communities perceive avoidance of a tool for communication, in this case television, as part of the communities’ sharing, participation, and common culture

Negotiating agency: Amish and ultra-Orthodox women’s responses to the Internet

This study explores how women in two devout religious communities cope with the Internet and its apparent incompatibility with their communities’ values and practices. Questionnaires containing both closed and open-ended questions were completed by 82 participants, approximately half from each community. While their discourses included similar framings of danger and threat, the two groups manifested different patterns of Internet use (and nonuse). Rigorous adherence to religious dictates is greatly admired in these communities, and the women take pride in manipulating their status in them. Their agency is reflected in how they negotiate the tension inherent in their roles as both gatekeepers and agents-of-change, which are analyzed as valuable currencies in their cultural and religious markets

BIMA Array Detections of HCN in Comets LINEAR (C/2002 T7) and NEAT (C/2001 Q4)

We present interferometric detections of HCN in comets LINEAR (C/2002 T7) and NEAT (C/2001 Q4) with the Berkeley-Illinois-Maryland Association (BIMA) Array. With a 25.4"x20.3" synthesized beam around Comet LINEAR and using a variable temperature and outflow velocity (VTOV) model, we found an HCN column density of N_T=6.4+-2.1x10^12 cm^-2, and a production rate of Q(HCN)=6.5+-2.2x10^26 s^-1, giving a production rate ratio of HCN relative to H_2O of ~3.3+-1.1x10^-3 and relative to CN of ~4.6+-1.5. With a 21.3"x17.5" synthesized beam around Comet NEAT and using a VTOV model, we found an HCN column density of N_T=8.5+-4.5x10^11 cm^-2, and a production rate of Q(HCN)=8.9+-4.7x10^25 s^-1, giving a production rate ratio of HCN relative to H_2O of ~7.4+-3.9x10^-4 and relative to CN of ~0.3+-0.2. For both comets, the production rates relative to H_2O are similar to those found in previous comet observations. For Comet LINEAR the production rate relative to CN is consistent with HCN being the primary parent species of CN, while for Comet NEAT it is too low for this to be the case.Comment: 20 pages, 2 figures, to be published in the Astrophysical Journa

Elastic scattering of the long-lived hadrons

The authors propose to measure the elastic scattering of the charged hadrons {pi}{sup {+-}}, K{sup {+-}}, p and {bar p} over a region of momentum transfer up to about 1 GeV/c. Special attention will be given to the Coulomb interference region. This experimental program is based on the use of novel detectors of high spatial resolution which we have developed

Elastic scattering of the hyperons

We propose to measure the elastic scattering of the hyperons {Eta}{sup -}, {Xi}{sup -}, {Omega}{sup -} and {Lambda}{sup 0} over a region of momentum transfer up to about 1 GeV/c. As part of this program we will measure the production cross sections of the negative and positive hyperons and carry out a search for new particles with lifetime {approx}> 10{sup -11} seconds. This experimental program is based on the use of novel detectors of high spatial resolution which we have developed