19 research outputs found
The role of iconic gestures and mouth movements in face-to-face communication
Human face-to-face communication is multimodal: it comprises speech as well as visual cues, such as articulatory and limb gestures. In the current study, we assess how iconic gestures and mouth movements influence audiovisual word recognition. We presented video clips of an actress uttering single words accompanied, or not, by more or less informative iconic gestures. For each word we also measured the informativeness of the mouth movements from a separate lipreading task. We manipulated whether gestures were congruent or incongruent with the speech, and whether the words were audible or noise vocoded. The task was to decide whether the speech from the video matched a previously seen picture. We found that congruent iconic gestures aided word recognition, especially in the noise-vocoded condition, and the effect was larger (in terms of reaction times) for more informative gestures. Moreover, more informative mouth movements facilitated performance in challenging listening conditions when the speech was accompanied by gestures (either congruent or incongruent) suggesting an enhancement when both cues are present relative to just one. We also observed (a trend) that more informative mouth movements speeded up word recognition across clarity conditions, but only when the gestures were absent. We conclude that listeners use and dynamically weight the informativeness of gestures and mouth movements available during face-to-face communication
Multimodal Comprehension in Left Hemisphere Stroke Patients
Hand gestures, imagistically related to the content of speech, are ubiquitous in face-to-face communication. Here we investigated people with aphasia’s (PWA) processing of speech accompanied by gestures using lesion-symptom mapping. Twenty-nine PWA and 15 matched controls were shown a picture of an object/action and then a video-clip of a speaker producing speech and/or gestures in one of the following combinations: speech-only, gesture-only, congruent speech-gesture, and incongruent speech-gesture. Participants’ task was to indicate, in different blocks, whether the picture and the word matched (speech task), or whether the picture and the gesture matched (gesture task). Multivariate lesion analysis with Support Vector Regression Lesion-Symptom Mapping (SVR-LSM) showed that benefit for congruent speech-gesture was associated with 1) lesioned voxels in anterior fronto-temporal regions including inferior frontal gyrus (IFG), and sparing of posterior temporal cortex and lateral temporal-occipital regions (pTC/LTO) for the speech task, and 2) conversely, lesions to pTC/LTO and sparing of anterior regions for the gesture task. The two tasks did not share overlapping voxels. Costs from incongruent speech-gesture pairings were associated with lesioned voxels in these same anterior (for the speech task) and posterior (for the gesture task) regions, but crucially, also shared voxels in superior temporal gyri (STG) and middle temporal gyri (MTG), including the anterior temporal lobe. These results suggest that IFG and pTC/LTO contribute to extracting semantic information from speech and gesture, respectively; however, they are not causally involved in integrating information from the two modalities. In contrast, regions in anterior STG/MTG are associated with performance in both tasks and may thus be critical to speech-gesture integration. These conclusions are further supported by associations between performance in the experimental tasks and performance in tests assessing lexical-semantic processing and gesture recognition
Line Graphs of Weighted Networks for Overlapping Communities
In this paper, we develop the idea to partition the edges of a weighted graph
in order to uncover overlapping communities of its nodes. Our approach is based
on the construction of different types of weighted line graphs, i.e. graphs
whose nodes are the links of the original graph, that encapsulate differently
the relations between the edges. Weighted line graphs are argued to provide an
alternative, valuable representation of the system's topology, and are shown to
have important applications in community detection, as the usual node partition
of a line graph naturally leads to an edge partition of the original graph.
This identification allows us to use traditional partitioning methods in order
to address the long-standing problem of the detection of overlapping
communities. We apply it to the analysis of different social and geographical
networks.Comment: 8 Pages. New title and text revisions to emphasise differences from
earlier paper
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging
Objective: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain structure and therapy response. Methods: A cross-over randomised repeated measures trial with five testing time points (12-week intervals), conducted at the university or participants' homes, captured baseline (T1), therapy (T2-T4) and maintenance (T5) effects. Participants with chronic poststroke aphasia and spoken language comprehension impairments completed consecutive Listen-In and standard care blocks (both 12 weeks with order randomised). Repeated measures analyses of variance compared change in spoken language comprehension on two co-primary outcomes over therapy versus standard care. Three structural MRI scans (T2-T4) for each participant (subgroup, n=25) were analysed using cross-sectional and longitudinal voxel-based morphometry. Results: Thirty-five participants completed, on average, 85 hours (IQR=70–100) of Listen-In (therapy first, n=18). The first study-specific co-primary outcome (Auditory Comprehension Test (ACT)) showed large and significant improvements for trained spoken words over therapy versus standard care (11%, Cohen’s d=1.12). Gains were largely maintained at 12 and 24 weeks. There were no therapy effects on the second standardised co-primary outcome (Comprehensive Aphasia Test: Spoken Words and Sentences). Change on ACT trained words was associated with volume of pretherapy right hemisphere white matter and post-therapy grey matter tissue density changes in bilateral temporal lobes. Conclusions: Individuals with chronic aphasia can improve their spoken word comprehension many years after stroke. Results contribute to hemispheric debates implicating the right hemisphere in therapy-driven language recovery. Listen-In will soon be available on GooglePlay. Trial registration number: NCT02540889
Individual and Neighborhood Determinants of Survey Nonresponse – An Analysis Based on a New Subsample of the German Socio-Economic Panel (SOEP), Microgeographic Characteristics and Survey-Based Interviewer Characteristics
Listen-In: high-dose home-based auditory comprehension therapy is achievable and effective
Dosimetric analysis of mid-position vs ITV conformational plans for locally advanced NSCLC. Preliminary results
International audiencePurpose/Objective: Since September 2012, 14 patients with locally advanced NSCLC were included in a phase 2 randomized clinical trial that compares ITV and mid-position conformational planning strategies (50 patients planned). We provide here a preliminary dosimetric analysis in terms of target volumes variation and normal tissue exposure
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Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging
Objective: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain structure and therapy response. Methods: A cross-over randomised repeated measures trial with five testing time points (12-week intervals), conducted at the university or participants' homes, captured baseline (T1), therapy (T2-T4) and maintenance (T5) effects. Participants with chronic poststroke aphasia and spoken language comprehension impairments completed consecutive Listen-In and standard care blocks (both 12 weeks with order randomised). Repeated measures analyses of variance compared change in spoken language comprehension on two co-primary outcomes over therapy versus standard care. Three structural MRI scans (T2-T4) for each participant (subgroup, n=25) were analysed using cross-sectional and longitudinal voxel-based morphometry. Results: Thirty-five participants completed, on average, 85 hours (IQR=70–100) of Listen-In (therapy first, n=18). The first study-specific co-primary outcome (Auditory Comprehension Test (ACT)) showed large and significant improvements for trained spoken words over therapy versus standard care (11%, Cohen’s d=1.12). Gains were largely maintained at 12 and 24 weeks. There were no therapy effects on the second standardised co-primary outcome (Comprehensive Aphasia Test: Spoken Words and Sentences). Change on ACT trained words was associated with volume of pretherapy right hemisphere white matter and post-therapy grey matter tissue density changes in bilateral temporal lobes. Conclusions: Individuals with chronic aphasia can improve their spoken word comprehension many years after stroke. Results contribute to hemispheric debates implicating the right hemisphere in therapy-driven language recovery. Listen-In will soon be available on GooglePlay. Trial registration number: NCT02540889
Mid-position treatment strategy for locally advanced lung cancer: a dosimetric study
International audienceObjectives The internal target volume (ITV) strategy generates larger planning target volumes (PTVs) in locally advanced non-small cell lung cancer (LA-NSCLC) than the Mid-position (Mid-p) strategy. We investigated the benefit of the Mid-p strategy regarding PTV reduction and dose to the organs at risk (OARs). Methods 44 patients with LA-NSCLC were included in a randomized clinical study to compare ITV and Mid-p strategies. GTV were delineated by a physician on MIP images and on Mid-p images from four-dimensional CTs. CTVs were obtained by adding 6mm uniform margin for microscopic extension. CTV to PTV margins were calculated using the van Herk's recipe for setup and delineation errors. For the Mid-p strategy, the mean target motion amplitude was added as a random error. For both strategies, 3D conformal plans delivering 60 to 66Gy to PTV were performed. PTVs, dose-volume parameters for OARs (lung, esophagus, heart, spinal cord) were reported and compared. Results With the Mid-p strategy, the median of volume reduction was 23.5cm 3 (p=0.012) and 8.8cm 3 (p=0.0083) for PTVT and PTVN respectively; the median mean lung dose (MLD) reduction was 0.51Gy (p=0.0057). For 37.1% of the patients, delineation errors led to smaller PTV with the ITV strategy than with the Mid-p strategy. Conclusion PTV and MLD were significantly reduced using the Mid-p strategy. Delineation uncertainty can unfavorably impact the advantage. Advances in knowledge To the best of our knowledge, this is the first dosimetric comparison study between ITV and Mid-p strategies for LA-NSCLC. Mid-p strategy significantly reduces tumor, nodal PTVs and MLD.