Physical capacity and balance ability after lower limb amputation

"The mean causes of lower extremity amputation, and the main goals and means of comprehensive rehabilitation in period of prior to surgery, acute postoperative and prosthetic training has been presented in this paper. In the paper are described most common problems after lower limb amputation, such as deterioration of muscle strength and balance and scientific search of optimal rehabilitation programs for patients after lower limb amputation on regaining and development balance and walking ability. It was formed some conclusions: applied individual comprehensive rehabilitation program increase lower limb amputees physical capacity and functional independence; properly selected and fitted lower limb prosthesis improves patients balance and walking abilities

A comparison of comprehensive rehabilitation and comprehensive rehabilitation with feed-back balance training for acute stroke patients

"60% of stroke survivors become disabled due to motor and cognitive disorders that have an effect on the person’s quality of life. Early comprehensive rehabilitation after acute stroke is very important, because it affects the course of the disease, functional independence level and conditions the better quality of life. Most important factors affecting on the patient’s functional independence is a level of balance disorders in patients after stroke. Therefore the influence of different factors on the results of comprehensive rehabilitation in early period of stroke and the relation between the balance disorders and functional independence, the relation between balance tests and various factors that can influence the results of balance alteration has been presented in this paper. In the paper are described different influences of comprehensive rehabilitation and comprehensive rehabilitation with feed-back balance training on balance improvement in patients groups after stroke. It was formed some conclusions: comprehensive rehabilitation program increase balance and functional independence of the stroke patients; correlation between functional independence tests, routine balance tests and „MTD-balance“ system indications tests (p < 0.01) was determined, comprehensive rehabilitation program with feed-back balance training (using „MTD-balance“ system) improve balance and functional independence of stroke patients better than comprehensive rehabilitation program only

A comparison of comprehensive rehabilitation and comprehensive rehabilitation with feed-back balance training for acute stroke patients

"60% of stroke survivors become disabled due to motor and cognitive disorders that have an effect on the person’s quality of life. Early comprehensive rehabilitation after acute stroke is very important, because it affects the course of the disease, functional independence level and conditions the better quality of life. Most important factors affecting on the patient’s functional independence is a level of balance disorders in patients after stroke. Therefore the influence of different factors on the results of comprehensive rehabilitation in early period of stroke and the relation between the balance disorders and functional independence, the relation between balance tests and various factors that can influence the results of balance alteration has been presented in this paper. In the paper are described different influences of comprehensive rehabilitation and comprehensive rehabilitation with feed-back balance training on balance improvement in patients groups after stroke. It was formed some conclusions: comprehensive rehabilitation program increase balance and functional independence of the stroke patients; correlation between functional independence tests, routine balance tests and „MTD-balance“ system indications tests (p < 0.01) was determined, comprehensive rehabilitation program with feed-back balance training (using „MTD-balance“ system) improve balance and functional independence of stroke patients better than comprehensive rehabilitation program only

A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging

Hypoxia occurs in most solid tumors, and it has been shown to be an independent prognostic indicator of a poor clinical outcome for patients with various cancers. Therefore, constructing a nanosystem specifically targeting cancer cells under hypoxia conditions is a promising approach for cancer therapy. Herein, we develop a porous silicon (PSi)-based nanosystem for targeted cancer therapy. VD11-4-2, a novel inhibitor for carbonic anhydrase IX (CA IX), is anchored on PSi particles (VD-PSi). As CA IX is mainly expressed on the cancer cell membrane under hypoxia condition, this nanocomplex inherits a strong affinity toward hypoxic human breast adenocarcinoma (MCF-7) cells; thus, a better killing efficiency for the hypoxia-induced drug resistance cancer cell is observed. Furthermore, the release of doxorubicin (DOX) from VD-PSi showed pH dependence, which is possibly due to the hydrogen-bonding interaction between DOX and VD11-4-2. The fluorescence resonance energy transfer effect between DOX and VD11-4-2 is observed and applied for monitoring the DOX release intracellularly. Protein inhibition and binding assays showed that VD-PSi binds and inhibits CA IX. Overall, we developed a novel nanosystem inheriting several advantageous properties, which has great potential for targeted treatment of cancer cells under hypoxic conditions