Effect of mutagens on Mitotic Index and mitotic aberrations in M1 generations of Lablab purpureus (L.) Sweet

In the present investigation the effect of the different Chemical and Physical mutagens like EMS, Gamma rays and combination of both EMS and Gamma rays concentration  and doses were studied for the mitotic index and mitotic abnormalities in the M1generation . The Mitotic index is decreased with the increased in the concentration and doses of the mutagens. All the three mutagenic treatments EMS, Gamma rays and combination treatment induced the reduction in mitotic index. The maximum induction of mitotic index is observed in EMS followed by Combination and Gamma rays radiation. The different mitotic abnormalities like micronuclei, mis-orientation, stickiness, precocious movements, multiple bridges. The percentage of the mitotic abnormalities was increased with the increases in the dose or concentration of the mutagenic treatments. The highest percentage of the mitotic abnormalities was observed at EMS treatments followed by the Gamma rays and Combination treatments

Fuzzy Logic A Soft Computing Approach For E-Learning: A Qualitative Review

E-learning model has been developed rapidly because of development in technology, mobile platform such as smart phone and pad etc. But due to low rate of completion of e-learning platform it is necessary to analyze behavior characteristics of online learners which enhance the quality of learning. This can be achieved by recommending suitable e-contents available in learning servers that are based on learning style, learning pattern, time, environment, psychology and mood of learners. All these factors are uncertain. In such case fuzzy logic and neural network approach of soft computing is desirable to use and helps to take decision for prediction of e-learning. The aim of this paper is to study development and work in e-learning, adaptive learning and web-based learning globally. Also study for to develop reliable and efficient solution for e-learners and e-content provider. This paper represent studies of learning style prediction, learning style model, learning system and analysis of related work in e-learning and web environments. This is review of previous research in e-learning prediction

Assesment of Water Quality Parameters of Ulhas River in Thane District

Globally water resources are becoming increasingly vulnerable as a result escalating demand arising from the population growth, the need foe increased food production, expanding industrialisation due to rising living standards, pilution due to various anthropogenic activities, and climate change impacts Due to the water scarcity and poor water quality, it has been predicted that by 2050, at least one in four people are likely to live in a country with a shortage of freshwater. Water quality is a complex subject which involves physical, chemical, hydrological and biologicl characteristics of water and their complex and delicate realations

SOLUBILITY AND DISSOLUTION ENHANCEMENT OF PIOGLITAZONE USING SOLID DISPERSION TECHNIQUE

Objective: To design the study to improve the solubility and hence enhance the dissolution of hydrophobic drug Pioglitazone in order to increase its bioavailability.Methods: Solid dispersion of Pioglitazone using carriers Poloxomer 188 and HPβCD was formulated in different ratios by microwave induced fusion method. In particular, the Microwave technology has been considered in order to prepare an enhanced release dosage form for poorly water soluble drug Pioglitazone. Statistical Analysis: Their physicochemical characteristics and solubility were compared to the corresponding dispersions and marketed drug. Drug and polymer were further characterized by FTIR.Results: The results of FTIR revealed that no chemical interaction between the drug and the polymer exist.Conclusion: All the formulations showed a marked increase in drug release with the increase in the concentration of Poloxomer 188 and HPβCD.Â

A BRIEF REVIEW ON PROCESS ANALYTICAL TECHNOLOGY (PAT)

Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes. PAT checks the quality of raw material attributes both physically and chemically (i.e. at off-line, on-line, in-line). PAT involves a shift from testing the quality of building to the quality of products by testing at several intermediate steps. PAT saves a huge amount of time and money required for sampling and analysis of products. The main goal of PAT is to provide successful tools such as multivariate data analysis and acquisition tools, modern process analyzers or analytical chemistry, endpoint process monitoring, controlling tools and continuous improvement and knowledge improvement tools. In this review attempt has been carried out to explore the concept of PAT, different tools of PAT, goals of PAT, How it Works and Its benefits

Traditional Ethnomedicinal Knowledge Confined to the Pawra Tribe of Satpura Hills, Maharashtra, India

Ethnobotanical surveys can potentially bring out many different clues for the development of safe, effective and inexpensive indigenous remedies. Present study has been focussed on Pawra tribe of Nandurbar district of Maharashtra, India. Field surveys of this area were carried out during 2000–2005 through several field visits and interviews. The aim of the present study was primarily to evaluate and inverntorize medicinal uses of the plants known to Pawras and to encourage preservation of their culture, conservation and sustainable utilization of the plant wealth. After an extensive comparison with literature, about 80 unique or less known uses of 79 plant species belonging to 59 families are described. The documented ethnomedicinal usage of plants mostly pertains to cure asthma, inflammation, lactation, menstrual problems, poisonous bites, skin problems, stomach ache and tooth ache. We found that the study area is rich in ethnic and biodiversity and the tribe posses a valuable treasure of ethnobotanical knowledge. This wisdom available with the tribe is transmitted only through oral communication in locally-spoken, script-less language and therefore needs conservation. The plants used by the Pawra tribe are arranged alphabetically followed by family name, herbarium number, local name, parts used, mode of preparation and medicinal uses

Study of Thermoelectric Generator for Harnessing of the heat energy wasted from automobiles and Thermal Power Plant

The ever growing huge demand for electricity needs is to be fulfilled with taking in consideration the environment factor. Thus, recycling of energy must be done as effectively as possible. Harnessing of the heat energy wasted from automobiles, industries, domestic appliances etc. all of which can generate power is proposed in this paper. Industries and automobile sector is the main source for the supply of waste heat which can generate power that can be further used for powering various accessories thus increasing the overall efficiency of the system itself. Technology under study in this paper for waste heat recovery is called TEG which stands for Thermo Electric Generators based on the See beck effect. TEG is a device which makes use of the temperature gradient across it to generate an electromotive force (EMF). TEGs are most suitable for waste heat recovery applications due to lack of mechanical parts, low maintenance and high durability and are proved in space missions over the past decades. The focus of this paper is to study characteristics of TEG and factors affecting its performance in turn reducing the environmental impact. Power generation from automobile and thermal power plant and accordingly future scope can be defined

EFFECT OF PITHECELLOBIUM DULCE BENTH LEAVES IN DEXAMETHASONE INDUCED DIABETIC RATS

Objective: The objective of the present study was to study the effect of Pithecellobium dulce Benth (P. dulce) leaves in dexamethasone-induced diabetic rats.Methods: The authenticated P. dulce leaves were collected from a local area of Sangli, Maharashtra. The leaves of the plant were extracted with water and ethanol by maceration and soxhelation respectively. Acute toxicity studies of the both extracts were performed using rat and according to OECD 425 guidelines. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. The albino rats were divided into seven groups with five animals in each group. The diabetes was induced by dexamethasone (10 mg/kg, s. c.) and treated with extract and standard drug for 10 d. Then blood glucose, triglyceride, total cholesterol and glycogen level in liver, muscle and kidney were estimated according to standard procedures.Results: The study revealed that P. dulce at 200 mg/kg and 400 mg/kg showed significant (p Ë‚ 0.05) antidiabetic activity. All the extract treated groups showed a significant reduction in blood glucose level on 11th day when compared to diabetic control group. The significant increase in blood glucose, triglyceride, and total cholesterol level was observed in the diabetic control group when compared to normal control group. The liver and muscle glycogen level was decreased significantly (p Ë‚ 0.05) in the diabetic control group.Conclusion: It can be concluded that P. dulceaqueous and ethanolic extract at two different doses (200 mg/kg and 400 mg/kg) possesses antidiabetic and hypolipidemic activity.Â

Effect of Psoralea corylifolia on dexamethasone-induced insulin resistance in mice

AbstractThe whole plant of Psoralea corylifolia (PC) is traditionally used in the treatment of diabetes. Mice were treated with prestandardised dose of dexamethasone for 22days and effect of PC at the doses of 100, 200 and 300mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed. PC showed significant decrease in plasma glucose and serum triglyceride levels (p<0.01) at the dose of 100 and 200mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p<0.01) and there was significant decrease (p<0.01) in level of LPO.Hence it can be concluded that Psoralea carylifolia may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance