Optimal Analysis of Packaging Products of MAHEU Plant in Intafact Beverages Limited Using GPALS and MATLAB Optimization Software

This work focused on the optimization of the two packaging products; Supershake and Chibuku made up of three and two parts respectively. Copolymer polypropylene and white or colored batch materials are the two raw materials needed to produce the two packaging products. The manufacturing plan was developed for the organization. The production inputs of 1.11, 6.67, 15.78, 2.47 and 7.70 units were generated as the objective function coefficients; 308 hours per month for day shift and 364 hours per month for night shift were established. Production time of 10 seconds, 20 seconds, 12 second, 10 seconds and 12 seconds per unit of the five parts were established. The manufacturing constraints in terms of machine capacities, material availability, time and labour were extensively used to develop an integer linear programming model to obtain the optimum quantities of each part that will yield the maximum profit. The developed model was analyzed with GPALS and MATLAB optimization solver to obtain results for the linear programming model which gave a monthly production net profit of N3,751,932. A decision support system was developed for the manufacturing planning to assist the management of Maheu plant in Intafact Beverages Limited in decision making. The model is now being used in the manufacturing plan of the company and also recommended for application in organizations with similar production inputs. Keywords: Manufacturing plan, Production inputs, Manufacturing constraints,  Optimization, Profit and Decision makin

Use of absolute lymphocyte count or neutrophil ingestion rate of nitroblue tetrazolium (NBT) as alternative index to CD4+T-cell count to initiate ART in the management of HIV/AIDS disease

The present study was designed to evaluate absolute lymphocyte count or neutrophil ingestion rate of NBT as alternative indices to CD4+ T cell count in the management of HIV/AIDS subjects. 158 adult participants (male = 70, female = 88) were recruited for the study and grouped as: (i) Symptomatic HIV subjects with or without malaria (ii) Asymptomatic HIV subjects (iii) HIV seronegative subjects with or without malaria. Blood samples taken from these participants were analyzed using standard procedures for absolute lymphocyte count, neutrophil ingestion rate of NBT and CD4+ T cell count. The result showed that the mean absolute lymphocyte and neutrophil ingestion rate of NBT were significantly reduced in both symptomatic and asymptomatic HIV subjects with or without malaria infection when compared to the control group. The CD4+ T cell count was significantly reduced in the two groups and positively correlated with the absolute lymphocyte count (r = 0.301, P<0.05, r = 0.403, P<0.05) and neutrophil ingestion rate of NBT (r = 0.116, P = 0.01, r = 0.359, P<0.01) with or without malaria infection respectively. This finding suggests that in resource limited settings, absolute lymphocyte count or neutrophil ingestion rate of NBT could be used as alternative to CD4 count to monitor or initiate ART where the later is not easily accessible especially in a malaria endemic area.Keywords: Absolute lymphocyte count, NBT, ART, CD4+ T-cell count, HI

Packed cell volume and serum iron in subjects with HIV-malaria co-infection in Nnewi, South-Eastern Nigeria

The present study was designed to assess the PCV and serum iron in HIV-malaria co-infected subjects in Nnewi, South Eastern Nigeria. 207 participants aged between 16-72 (44 ± 28) years were recruited andclassified as follows based on standard screening and WHO criteria: (i) Asymptomatic HIV stage I subjects with or without malaria. (ii) Symptomatic HIV stage II subjects with or without malaria and not on (ART). (iii) HIV/AIDS subjects with or without malaria and on ART. (vi) HIV seronegative control subjects with or without malaria. Blood sample from these participants were analyzed for HIV seroreactivity, Plasmodium falciparum antigen, parasite density, serum iron concentrations and PCV using Standard Laboratory methods. The result showed that serum iron and PCV were significantly reduced amongst all the groups studied when compared with the control (

Reduced serum tetanus antibody titre in HIV infected subjects with malaria co-infection in a malaria endemic area of Nigeria

Tetanus infection is widespread and difficult to completely eradicate. Thus the present study was designed to assess the tetanus antibody titre in HIV infected subjects in relation to the presence or absence of malaria parasitaemia. 107 subjects consisting of asymptomatic group (asymptomatic HIV, n=17 and asymptomatic HIV-Malaria co-infection, n=17), symptomatic group (symptomatic HIV, n=18 and symptomatic HIV-Malaria co-infection, n=17), and control group (control without malaria, n=19 and control with malaria, n=19) participated in the study. Blood sample collected from the participants were used for the determination of packed cell volume, CD4+ T cell count, malaria parasite, HIV seropositivity and tetanus antibody titre using standard laboratory methods. The tetanus antibody titre was significantly reduced in symptomatic HIV infected subjects with malaria co-infection compared with symptomatic HIV infected subjects without malaria (

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

HIV and malaria co-infections affect iron status. The present study was designed to determine the collective predictive power of some iron markers in HIV infected and malaria co-infected participants. For thisstudy, 101 participants were randomly recruited from indivividuals requesting for HIV screening. The participants were grouped as ‘asymptomatic HIV participants (n=36); asymptomatic HIV-malaria co-infected participants (n=19); symptomatic HIV participants (n=16) and HIV uninfected control participants (n=30). Blood analysis were performed for HIV infection, malaria infection, haemoglobin (g/dl), CD4 + T cell count(/mm3), albumin (g/l), iron (ug/dl), UIBC (ug/dl), TIBC (ug/dl) and percent transferrin saturation (TS%). The analysis of variance (ANOVA) showed that the blood concentrations of haemoglobin (f=4.805,

RSM and ANN modelling of the mechanical properties of self-compacting concrete with silica fume and plastic waste as partial constituent replacement

In this study, Response Surface Methodology (RSM) and Artificial Neural Networks (ANN) was used to predict the mechanical properties of self‐compacting concrete (SCC) with silica fume as partial cement replacement and Polyethylene terephthalate (PET) solid waste as partial sand replacement. PET plastic was varied between 0 and 20 wt% while the silica fume was varied between 0 and 40 wt%. The parameters investigated were the compressive strength, tensile strength and impact strength of SCC. The RSM model was fairly accurate (R2 ≥ 0.92) in predicting the mechanical properties. The model was statistically significant (p‐value 0.93) for training, testing and validation. Parity plots revealed that both the ANN and RSM models do not have any prediction bias. However, the ANN model is superior because of its higher accuracy and the use of admixtures enhanced the workability suitability for dataset. The 3D microstructural analysis showed that the interfacial adhesion between the aggregates and the cementitious materials reduced at increased partial replacement leading to a decrease in the strengt

Effectiveness of Treatment Outcomes of Public Private Mix Tuberculosis Control Program in Eastern Nigeria

Effective tuberculosis treatment has been shown to have significant effect on the control of tuberculosis. Completion of treatment of active cases is therefore the most important priority of tuberculosis control programmes. Descriptive statistics with a retrospective cohort study design used to analyze secondary data set (2007-2010) of patients accessing TB-DOTS treatment in two facilities (Nnamdi Azikiwe University Teaching Hospital, NAUTH and Department of Health Services Tuberculosis and Leprosy  Control Unit Nnewi North Local Government Area (L.G.A.) Secretariat, DHSTLCU ) as public health facilities and other two facilities ( Immaculate Heart of Catholic Church Hospital, IHCCH  and Diocesan Anglican Communion Hospital, DACH) as private health facilities in Nnewi North L.G.A., Anambra State. Gender of patients were male: female 54%(1016 patients) : 46% (883 patients) and 53%(63 patients) : 47%(56 patients) in public and private health facilities respectively . Using WHO (1996) standards the health facilities adjudged as efficient were: in 2007, private facilities using the indicator  of treatment failure rate; private facilities using the indicator of death rate;  public facilities and private facilities using  the indicator of transfer-out rate ; public facilities using the indicator of  treatment completion rate. In 2008, effective health facilities were: private health facilities using the indicator of failure rate; public and private health facilities using the indicator of transfer-out rate; private facilities using the indicator of treatment completion rate. In 2009, effective health facilities were public and private health facilities using indicator of treatment failure rate; public and private health facilities using the indicator of death rate; public and private facilities using the indicator of transfer out; public and private facilities using the indicator of treatment completion rate. In 2010, effective health facilities were: private health facilities using the indicator of  cure rate; private facilities using the indicator of death rate ; public and private facilities using the indicator of transfer-out; public facilities using the indicator of treatment completion rate. In conclusion, private health facilities were more effective than public health facilities  by the several indicators over the four year period.  Future research is needful to use primary and secondary data sets in assessment of TB control program effectiveness; technical efficiency assessment using non-parametric statistics will assess the validity of assessing effectiveness using only the WHO standards; identify centre-specific factors associated with poor treatment outcome; institutionalizing a reward system for effective TB-DOTS facilities will engender healthy competition in the Public Private Mix for sustained effectiveness; the Monitoring and Evaluation tools especially the treatment card for data capture should be improved upon for comprehensiveness of patients socio-economic history. Keywords: Tuberculosis, Effectiveness, Treatments Outcomes, Public Private Mi

Occurrence and distribution of pepper veinal mottle virus and cucumber mosaic virus in pepper in Ibadan, Nigeria

Viral diseases constitute obstacles to pepper production in the world. In Nigeria, pepper plants are primarily affected by pepper veinal mottle virus (PVMV), Cucumber mosaic virus (CMV), Pepper leaf curl Virus (TLCV), Tobacco mosaic virus (TMV), Pepper mottle virus (PMV) and a host of other viruses. The experiment was carried out with a diagnostic survey on the experimental field of the National Horticultural Research Institute, Ibadan, Nigeria and on pepper farms in six local government areas within Ibadan Oyo State, Nigeria, forty samples were collected from each of the farms. Diseased samples were obtained from the field and taken to the laboratory for indexing. In ELISA test some of the samples from the pepper farms showed positive reaction to single infection with PVMV (36.79%), CMV (22.14%) while some others showed positive reaction to mixed infection of the two viruses (10%) but some also negative reaction to PVMV and CMV antisera (31.07)