Determinación de la tensión de laminación en caliente a partir de ensayos de tracción

RESUMEN La predicción del comportamiento mecánico de aceros laminados en caliente es un aspecto importante durante el procesamiento industrial. En el presente trabajo, las tensiones necesarias para el proceso de laminado, fueron estimadas usando tres métodos, el primero de los cuales se basa en la aplicación del modelo de Sellars, que toma en cuenta el coeficiente de fricción y el límite elástico. El segundo método, estima la tensión de laminado a partir de la tensión promedio obtenida durante los ensayos de tracción. El tercer método, estima la tensión de laminado a partir de los datos de potencia consumida por el equipo de laminación. Esta metodología fue aplicada en este estudio a un acero al carbono. La conclusión de este trabajo es que los resultados obtenidos por los métodos basados en el modelo de Sellars y de la potencia consumida, son coincidentes, en tanto que el método basado en la tensión de tracción, presenta valores ligeramente menores a los predichos por los otros modelos. ABSTRACT Prediction of mechanical behavior of hot rolled steels is an important aspect during industrial processing. The rolling stress needed to the process were estimated using three methods, the first of which is related to the Sellars`s model that takes into account the friction coefficient and the yield stress. The second method estimates the rolling stress as the average stress obtained during the tensile tests. The third method, estimates the rolling stress from the data of power consumed by the rolling equipment. This methodology was applied in this study to a carbon steel. The conclusion of the work is that results obtained by Sellars`s and consumed power, are coincident. The method based on the average tensile stress predicts stresses lower than those obtained with other two methods

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition

Koolen-de Vries syndrome (KdVS) is a multi-system disorder characterized by intellectual disability, friendly behavior, and congenital malformations. The syndrome is caused either by microdeletions in the 17q21.31 chromosomal region or by variants in the KANSL1 gene. The reciprocal 17q21.31 microduplication syndrome is associated with psychomotor delay, and reduced social interaction. To investigate the pathophysiology of 17q21.31 microdeletion and microduplication syndromes, we generated three mouse models: 1) the deletion (Del/+); or 2) the reciprocal duplication (Dup/+) of the 17q21.31 syntenic region; and 3) a heterozygous Kansl1 (Kans1+/-) model. We found altered weight, general activity, social behaviors, object recognition, and fear conditioning memory associated with craniofacial and brain structural changes observed in both Del/+ and Dup/+ animals. By investigating hippocampus function, we showed synaptic transmission defects in Del/+ and Dup/+ mice. Mutant mice with a heterozygous loss-of-function mutation in Kansl1 displayed similar behavioral and anatomical phenotypes compared to Del/+ mice with the exception of sociability phenotypes. Genes controlling chromatin organization, synaptic transmission and neurogenesis were upregulated in the hippocampus of Del/+ and Kansl1+/- animals. Our results demonstrate the implication of KANSL1 in the manifestation of KdVS phenotypes and extend substantially our knowledge about biological processes affected by these mutations. Clear differences in social behavior and gene expression profiles between Del/+ and Kansl1+/- mice suggested potential roles of other genes affected by the 17q21.31 deletion. Together, these novel mouse models provide new genetic tools valuable for the development of therapeutic approaches.PMC553161

Aceros Dual-Phase, su historia, fundamentos y posibilidades futuras

Estudio que involucra los fundamentos en la obtención de aceros Dual-Phase en caliente, frío y recorridos, junto a las tendencias actuales de este tipo de aceros