Epidemiology and treatment for thyroid cancer

The thyroid gland produces thyroid hormones which are important in the normal regulation of the metabolism of the body. Thyroid cancer is the most common malignancy of the endocrine system consisting of several subtypes like papillary carcinoma, and follicular carcinoma, medullary carcinoma, and anaplastic carcinoma. Treatment depends on a number of factors, including the type of thyroid cancer, the size of the nodule, the patient's age, and whether the cancer has spread. Most cases of thyroid cancer can be cured with treatment like Radiation therapy chemotherapy and radioactive iodine. Recommended thyroid treatment approaches depend on the type of thyroid disease, and in some cases, the severity of the condition. © 2011 Srilatha B, et al

Security Aspects in Big Data

ABSTRACT: The measure of information in world is developing step by step. Information is developing due to utilization of web, smart phone and social network. Big data is a collection of data sets which is huge in size and also complex. Generally the data size is Petabyte and Exabyte. Traditional database systems were unable to analyze, capture and store the vast amount of this data. As the internet is growing, measure of enormous information keep on growing. Big data analytics afford new ways for organizations and government to dissect unstructured data. Now a days, big data is a standout amongst the most talked point in an Information Technology industry. It will play a critical part in future. Big data changes the way that information is overseen and utilized. The various applications like, banking, education, healthcare, retail, traffic management, etc., use a big data to store huge amount of data. In this paper, we discuss the characteristics of big data and security issues within it

From rods to helices: evidence of a screw-like nematic phase

Evidence of a special chiral nematic phase is provided using numerical simulation and Onsager theory for systems of hard helical particles. This phase appears at the high density end of the nematic phase, when helices are well aligned, and is characterized by the C$_2$ symmetry axes of the helices spiraling around the nematic director with periodicity equal to the particle pitch. This coupling between translational and rotational degrees of freedom allows a more efficient packing and hence an increase of translational entropy. Suitable order parameters and correlation functions are introduced to identify this screw-like phase, whose main features are then studied as a function of radius and pitch of the helical particles. Our study highlights the physical mechanism underlying a similar ordering observed in colloidal helical flagella [E. Barry et al. \textit{Phys. Rev. Lett.} \textbf{96}, 018305 (2006)] and raises the question of whether it could be observed in other helical particle systems, such as DNA, at sufficiently high densities.Comment: List of authors correcte

ESTIMATION OF PAROXETINE HYDROCHLORIDE FROM ITS TABLET FORMULATION BY UV SPECTROPHOTOMETRY

A simple, precise and accurate UV Spectrophotometric method was developed for the estimation of Paroxetine hydrochloride. The developed method obeyed Beer-Lambert’s law in the concentration range of 5-30 µg/ml with a correlation coefficient of 0.995. The recovery study was carried out at three different levels and was found to be satisfactory. The percent amount of drug estimated by this method is 100%, found to be in good agreement with label claim of marketed tablet formulation. The validation parameters like linearity, precision, accuracy, robustness and ruggedness were studied and were found to be within limits. The proposed method can be adopted for routine quality control analysis of estimation of Paroxetine hydrochloride in pharmaceutical formulation

Experimental studies and Development of Modelling equation of Quercetin from Pine apple peel using Soxhlet Extractor

ABSTRACT: Quercetin is a flavonoid widely distributed in nature. It is rich in foods including fruits, vegetables, leaves and grains. It has been used in medicine to control the capillary fragility and blood breeding. It shows pharmacological activities like anti-oxidant, anti-cancer, anti-viral and anti-inflammatory activities etc. The present study was intended for the optimization of extraction of Quercetin from pine apple peel and its various physicochemical parameters have been studied. For the extraction of Quercetin the optimum results were observed for the effect of different solvents, soaking time, different solvent percentages, effect of pH, different volumes of hexane with methanol as solvent, extraction time with hexane were methanol, 1day, 80% (v/v), 7.0, 1:1 ratio and 1hr respectively. The highest Quercetin concentration for optimized condition was 37μg/ml. Methanol was found to be the best solvent for the extraction of Quercetin from pineapple peel by soxhlet extractor. It was carried out for 90 min and an optimum concentration obtained at 50 min with a concentration of 50µg/ml .This Solvent extraction using soxhlet extractor was conduct to verify the mathematical model proposed in this work. The final form of proposed models were E(t) = At 2 +Bt+C Where A,B&C are constants,E s =yield extract(µg/ml of quercetin) and t=extraction time(min). The final form of proposed equation is E (t)= -0.018t 2 +1.591t with R 2 =0.894

Influence of ZrO2_{2} Addition on Structural and Biological Activity of Phosphate Glasses for Bone Regeneration

Zirconium doped calcium phosphate-based bioglasses are the most prominent bioactive materials for bone and dental repair and regeneration implants. In the present study, a 8ZnO-22Na2O-(24 - x)CaO-46P2O5-xZrO2 (0.1 ≤ x ≤ 0.7, all are in mol%) bioglass system was synthesized by the conventional melt-quenching process at 1100 °C. The glass-forming ability and thermal stability of the glasses were determined by measuring the glass transition temperature (Tg), crystallization temperature (Tc), and melting temperature (Tm), using differential thermal analysis (DTA). The biological activity of the prepared samples was identified by analyzing X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy-energy dispersive spectra (SEM-EDS), before and after immersion in simulated body fluid (SBF) for various intervals of 0, 1 and 5 days, along with the magnitude of pH and the degradation of glasses also evaluated. The obtained results revealed that the glass-forming ability and thermal stability of glasses increased with the increase in zirconia mol%. The XRD, FTIR, and SEM-EDS data confirmed a thin hydroxyapatite (HAp) layer over the sample surface after incubation in SBF for 1 and 5 days. Furthermore, the development of layer found to be increased with the increase of incubation time. The degradation of the glasses in SBF increased with incubation time and decreased gradually with the increase content of ZrO2 mol% in the host glass matrix. A sudden rise in initial pH values of residual SBF for 1 day owing to ion leaching and increase of Ca2+ and PO43- ions and then decreased. These findings confirmed the suitability of choosing material for bone-related applications

Genetic variability, correlation and path analysis for yield and biochemical traits in velvet bean [Mucuna pruriens (L.)]

Not AvailableMucuna pruriens (L.) is an important medicinal plant and belonging to the family Fabaceae. The seeds of velvet bean are used in Ayurvedic System of Medicine to relief the symptoms of Parkinson’s disease. Correlation studies provide information about the relative contribution of various component traits on seed yield per plant and help in effective identification and selection of superior types. Fifteen F1 crosses resulting from 6 x 6 half diallel design without reciprocals were evaluated for yield and yield attributing traits. Higher estimates of GCV and PCV were recorded for inflorescence length. High heritability coupled with high genetic advance was recorded for dry pod yield per plant, seed yield per plant and these traits were governed by additive gene action hence those traits can be effective to improve the seed yield by selection method. In the present correlation studies, the characters like days taken to 50 percent flowering (rg=0.50 *, rp= 0.47 *), number of flowers per inflorescence (rg=0.54 *, rp=0.51 *), number of pods per bunch (rg=0.63 * *, rp= 0.59 * *) and dry pod yield per plant (rg=1.00 * *, rp=0.92 * *) and seeds per pod (rg=0.53 *, rp=0.48*) had exhibited significant and positive association with seed yield per plant at both genotypic and phenotypic levels and number of days taken to maturity had significant negative association with seed yield per plant at both levels. The results suggest the efficiency of direct selection of those contributing traits for seed yield improvement. However, in the path coefficient analysis showed that days taken to 50 percent flowering, number of flowers per inflorescence, pod length, number of pods per bunch, dry pod yield per plant, days taken to maturity and 100 seed weight had exerted direct effect on seed yield. The other traits plant height, inflorescence length, pod width, pod weight, number of bunches per plant and seeds per pod through positive indirect effects on seed yield per plant. For improving the seed yield in velvet bean emphasis should be selection on the characters that are showing direct positive effect on seed yield.Not Availabl