Rare books about Masuzawa Bunko Collection of CSAC

Last year, Center of Studies of Asian cultures (CSAC) created Masuzawa Bunko. Masuzawa Akiko that is sometime professor in Japan University and he presented his collection which comprises about 10,000 volumes for our Center. There are many rarely books about History of Education in Modern Chines. This time I would like to introduce some rarely books in Masuzawa Bunko, in addition to provide a research chance for our readers,東アジアの言語と表象文部科学省グローバルCOEプログラム 関西大学文化交渉学教育研究拠

Prototype development of a conduction-cooled LTS pulse coil for UPS-SMES

We are planning to develop a 1 MW, 1 sec UPS-SMES for a protection from a momentary voltage drop and an instant power failure. As the first step, we have been developing a 100 kJ class prototype UPS-SMES, using a low temperature superconducting coil because of its better cost and performance over the high temperature superconducting coil. However, the difficulty to utilize a pool-boiling LTS pulse coil is the reliability of operation. To solve this problem, a conduction-cooled LTS pulse coil has been designed and fabricated as a key component of the UPS-SMES. The reduction of AC loss and high stability are required for the SC conductor for the conduction-cooled coil because of a limited cooling capacity. The SC conductor of a NbTi/Cu compacted strand cable extruded with an aluminum is designed to have the anisotropic AC loss properties to minimize the coupling loss under the specified orientation of the time varying magnetic field. The coil was wound with a new twist-winding method in which the variation of twist angle of the conductor was controlled with the winding machine designed specifically for this purpose. The fabrication technique and performance of a conduction-cooled prototype LTS pulse coil are described

PtdIns4KII alpha generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes

Phosphatidylinositol 4-kinase IIα (PtdIns4KIIα) localizes to the trans-Golgi network and endosomal compartments and has been implicated in the regulation of endosomal traffic, but the roles of both its enzymatic activity and the site of its action have not been elucidated. This study shows that PtdIns4KIIα is required for production of endosomal phosphatidylinositol 4-phosphate (PtdIns(4)P) on early endosomes and for the sorting of transferrin and epidermal growth factor receptor into recycling and degradative pathways. Depletion of PtdIns4KIIα with small interfering RNA significantly reduced the amount of vesicular PtdIns(4)P on early endosomes but not on Golgi membranes. Cells depleted of PtdIns4KIIα had an impaired ability to sort molecules destined for recycling from early endosomes. We further identify the Eps15 homology domain–containing protein 3 (EHD3) as a possible endosomal effector of PtdIns4KIIα. Tubular endosomes containing EHD3 were shortened and became more vesicular in PtdIns4KIIα-depleted cells. Endosomal PtdIns(4,5)P2 was also significantly reduced in PtdIns4KIIα-depleted cells. These results show that PtdIns4KIIα regulates receptor sorting at early endosomes through a PtdIns(4)P-dependent pathway and contributes substrate for the synthesis of endosomal PtdIns(4,5)P2

Evolutionary history of the extant amphioxus lineage with shallow-branching diversification

© 2017 The Author(s).Amphioxus or lancelets have been regarded as a key animal in understanding the origin of vertebrates. However, the evolutionary history within this lineage remains unexplored. As the amphioxus lineage has likely been separated from other chordates for a very long time and displays a marked left-right asymmetry, its evolutionary history is potentially helpful in better understanding chordate and vertebrate origins. We studied the phylogenetic relationships within the extant amphioxus lineage based on mitochondrial genomes incorporating new Asymmetron and Epigonichthys populations, and based on previously reported nuclear transcriptomes. The resulting tree patterns are consistent, showing the Asymmetron clade diverging first, followed by the Epigonichthys and Branchiostoma clades splitting. Divergence time estimates based on nuclear transcriptomes with vertebrate calibrations support a shallow diversification of the extant amphioxus lineage in the Tertiary. These estimates fit well with the closure of seaways between oceans by continental drift, ocean currents, and present geographical distributions, and suggest a long cryptic history from the origin of amphioxus to its most recent diversification. Deduced character polarities based on phylogenetic analyses suggest that the common ancestor of the extant amphioxus existed in a tiny epibenthic state with larva-like appearance of extant amphioxus, likely with ciliate epidermis

Receptor Sorting within Endosomal Trafficking Pathway Is Facilitated by Dynamic Actin Filaments

Early endosomes (EEs) are known to be a sorting station for internalized molecules destined for degradation, recycling, or other intracellular organelles. Segregation is an essential step in such sorting, but the molecular mechanism of this process remains to be elucidated. Here, we show that actin is required for efficient recycling and endosomal maturation by producing a motile force. Perturbation of actin dynamics by drugs induced a few enlarged EEs containing several degradative vacuoles and also interfered with their transporting ability. Actin repolymerization induced by washout of the drug caused the vacuoles to dissociate and individually translocate toward the perinuclear region. We further elucidated that cortactin, an actin-nucleating factor, was required for transporting contents from within EEs. Actin filaments regulated by cortactin may provide a motile force for efficient sorting within early endosomes. These data suggest that actin filaments coordinate with microtubules to mediate segregation in EEs