26 research outputs found
Osteoid osteoma of the ethmoid bone associated with dacryocystitis
BACKGROUND: Osteoid osteomas (OO) are small, benign osteoblastic lesions. Ethmoid bone OO has been very rarely reported so far. CASE PRESENTATION: We report a case of a 16-year-old boy suffering from persistent epiphora and a mild pain in the area of median canthus, due to a bone density mass within the right ethmoid air cells extending to the ipsilateral right orbit. The mass was removed via an external ethmoidectomy approach. Histopathologic examination of the specimen set the diagnosis of OO. One year after the operation the patient is free of symptoms, while no recurrence occurred. CONCLUSION: A case of ethmoid bone OO associated with dacryocystitis is reported. Although benign and rare, OO should be considered in differential diagnosis of the ethmoid bone osteoblastic lesions
Antihistamine effects on experimental middle ear inflammatory model
Allergy is thought to be one of the etiologic factors in otitis media.
The purpose of this study was to determine the histopathologic effects
of H1 histamine receptor antagonists in an experimental
histamine-induced middle ear inflammation model. In group A (20
rabbits), histamine challenge followed a 3-day intramuscular
pretreatment with a single dose of 0.1 ml hydroxyzine hydrochloride (50
mg/ml) per day. In group B (20 rabbits), histamine challenge followed a
3-day pretreatment with a single dose 1.2 mg desloratadine per day
orally. In group C (20 rabbits), histamine challenge followed a 3-day
pretreatment with a single dose 1.2 mg levocetirizine per day orally. On
the fourth day after baseline otomicroscopy 0.5 ml histamine 20 mg/ml
was injected transtympanically on the right. Middle ear mucosa was
removed and the following parameters were assessed: edema, vascular
dilatation and congestion, inflammation, acute inflammatory component,
presence of eosinophils, activity of the inflammation and fibrosis. A
semi-quantitative grading system of 0-3 was used for grading of all
parameters and statistical analysis performed by using the Mann-Whitney
non-parametric test. Group A mucosae showed lower grades of all the
parameters evaluated compared with those of group B. Histopathology of
the mucosae of group C showed lower grade of inflammation compared with
group B with significant statistical difference for the seven parameters
tested. Our data validate the use of antihistamines in the treatment of
refractory OME of allergic origin. Oldest H1 antagonists can be replaced
by the newest agents who counteract successfully histamine effects,
without any interactions or adverse effects from central nervous system
Transtympanic versus intramuscular steroid administration in a histamine-induced inflammatory middle-ear model
Objectives: Assessment of the histopathologic effect of transtympanic
and intramuscular administration of dexamethasone in an in vivo
experimental animal model of middle-ear mucosal inflammation.
Methods: Fifty healthy rabbits weighting 1500-1800g were randomly
divided in three groups. In 10 animals (control group), 0.5 ml of a 20
mg/ml histamine solution was injected transtympanically. In 20 rabbits
(group A), histamine challenge followed a three day intramuscular
pretreatment with dexamethasone at 1 mg/kg per day. In 20 rabbits (group
B), histamine challenge followed pretreatment with dexamethasone via a
transtympanic route (0.3 ml, 1.2 mg dexamethasone). Middle-ear mucosa
was obtained for histopathology 30 minutes after histamine
administration. The following parameters were assessed: inflammation,
acute inflammatory component, presence of eosinophils, inflammatory
activity and fibrosis.
Results: Oedema, vascular dilatation and congestion, inflammation, the
presence of an acute (polymorphonuclear) inflammatory component, the
presence of eosinophils, and inflammatory activity were found to be of a
lesser grade in the mucosae of group B. All differences were found to be
statistically highly significant (p < 0.01) using the Mann-Whitney test.
Conclusion: Our findings validate the transtympanic route of
dexamethasone administration in counteracting histamine effects
Application of a ketogenic diet in children with autistic behavior: pilot study.
Item does not contain fulltextA pilot prospective follow-up study of the role of the ketogenic diet was carried out on 30 children, aged between 4 and 10 years, with autistic behavior. The diet was applied for 6 months, with continuous administration for 4 weeks, interrupted by 2-week diet-free intervals. Seven patients could not tolerate the diet, whereas five other patients adhered to the diet for 1 to 2 months and then discontinued it. Of the remaining group who adhered to the diet, 18 of 30 children (60%), improvement was recorded in several parameters and in accordance with the Childhood Autism Rating Scale. Significant improvement (> 12 units of the Childhood Autism Rating Scale) was recorded in two patients (pre-Scale: 35.00 +/- 1.41[mean +/- SD]), average improvement (> 8-12 units) in eight patients (pre-Scale: 41.88 +/- 3.14[mean +/- SD]), and minor improvement (2-8 units) in eight patients (pre-Scale: 45.25 +/- 2.76 [mean +/- SD]). Although these data are very preliminary, there is some evidence that the ketogenic diet may be used in autistic behavior as an additional or alternative therapy
Application of a ketogenic diet in children with autistic behavior: Pilot study
A pilot prospective follow-up study of the role of the ketogenic diet
was carried out on 30 children, aged between 4 and 10 years, with
autistic behavior. The diet was applied for 6 months, with continuous
administration for 4 weeks, interrupted by 2-week diet-free intervals.
Seven patients could not tolerate the diet, whereas five other patients
adhered to the diet for I to 2 months and then discontinued it. Of the
remaining group who adhered to the diet, 18 of 30 children (60%),
improvement was recorded in several parameters and in accordance with
the Childhood Autism Rating Scale. Significant improvement (> 12 units
of the Childhood Autism Rating Scale) was recorded in two patients
(pre-Scale: 35.00 +/- 1.41 [mean +/- SD]), average improvement (> 8-12
units) in eight patients (pre-Scale: 41.88 +/- 3.14[mean SD]), and
minor improvement (2-8 units) in eight patients (pre-Scale: 45.25 +/-
2.76 [mean +/- SD]). Although these data are very preliminary, there
is some evidence that the ketogenic diet may be used in autistic
behavior as an additional or alternative therapy