A systematic review of the association between circulating concentrations of C reactive protein and cancer.

The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case-control or cross-sectional studies, and only 9 studies had a prospective design. In most prevalent studies, CRP concentrations were found to be higher in patients with cancer than in healthy controls or controls with benign conditions. Of the nine large prospective studies identified in this review, four reported no relationship between circulating CRP levels and breast, prostate or colorectal cancers, and five studies found that CRP was associated with colorectal or lung cancers. Most of the studies evaluating CRP as a diagnostic marker of cancer did not present relevant statistical analyses. Furthermore, any association reported in the prevalent studies might reflect reverse causation, survival bias or confounding. The prospective studies provided no strong evidence for a causal role of CRP in cancer. Instead of further prevalent studies, more large prospective studies and CRP gene-cancer association studies would be valuable in investigating the role of CRP in cancer

Physics of Proximity Josephson Sensor

We study the proximity Josephson sensor (PJS) in both bolometric and calorimetric operation and optimize it for different temperature ranges between 25 mK and a few Kelvin. We investigate how the radiation power is absorbed in the sensor and find that the irradiated sensor is typically in a weak nonequilibrium state. We show in detail how the proximity of the superconductors affects the device response: for example via changes in electron-phonon coupling and out-of-equilibrium noise. In addition, we estimate the applicability of graphene as the absorber material.Comment: 13 pages, 11 figures, submitted to Journal of Applied Physics, v2: Addition of a new section discussing the radiation coupling to the device, several minor change

Huge thermoelectric effects in ferromagnet-superconductor junctions in the presence of a spin-splitting field

We show that a huge thermoelectric effect can be observed by contacting a superconductor whose density of states is spin-split by a Zeeman field with a ferromagnet with a non-zero polarization. The resulting thermopower exceeds $k_B/e$ by a large factor, and the thermoelectric figure of merit $ZT$ can far exceed unity, leading to heat engine efficiencies close to the Carnot limit. We also show that spin-polarized currents can be generated in the superconductor by applying a temperature bias.Comment: 5 pages, 4 figure

Theory of temperature fluctuation statistics in superconductor-normal metal tunnel structures

We describe the statistics of temperature fluctuations in a SINIS structure, where a normal metal island (N) is coupled by tunnel junctions (I) to two superconducting leads (S). We specify conditions under which this structure exhibits manifestly non-Gaussian fluctuations of temperature. We consider both the Gaussian and non-Gaussian regimes of these fluctuations, and the current fluctuations that are caused by the fluctuating temperature. We also describe a measurement setup that could be used to observe the temperature fluctuations.Comment: 10 pages, 9 figures, final versio

Fully Overheated Single-Electron Transistor

We consider the fully overheated single-electron transistor, where the heat balance is determined entirely by electron transfers. We find three distinct transport regimes corresponding to cotunneling, single-electron tunneling, and a competition between the two. We find an anomalous sensitivity to temperature fluctuations at the crossover between the two latter regimes that manifests in an exceptionally large Fano factor of current noise.Comment: 6 pages, 3 figures, includes Appendi

Absorption of heat into a superconductor-normal metal-superconductor junction from a fluctuating environment

We study a diffusive superconductor-normal metal-superconductor junction in an environment with intrinsic incoherent fluctuations which couple to the junction through an electromagnetic field. When the temperature of the junction differs from that of the environment, this coupling leads to an energy transfer between the two systems, taking the junction out of equilibrium. We describe this effect in the linear response regime and show that the change in the supercurrent induced by this coupling leads to qualitative changes in the current-phase relation and for a certain range of parameters, an increase in the critical current of the junction. Besides normal metals, similar effects can be expected also in other conducting weak links.Comment: 5 pages, 4 figures - supplementary information included: 3 pages, 1 figure; minor modifications to the text and Fig. 2, added Ref. 1

High-temperature surface superconductivity in topological flat-band systems

We show that the topologically protected flat band emerging on a surface of a nodal fermionic system promotes the surface superconductivity due to an infinitely large density of states associated with the flat band. The critical temperature depends linearly on the pairing interaction and can be thus considerably higher than the exponentially small bulk critical temperature. We discuss an example of surface superconductivity in multilayered graphene with rhombohedral stacking