Histologic Evaluation of the Efficacy of rhBMP-2 Compared With Autograft Bone in Sheep Spinal Anterior Interbody Fusion

Study Design. The sheep anterior lumbar spinal fusion model was used to study the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2)–collagen composite in comparison with autograft to enhance spinal interbody fusion. Comparisons were drawn from temporal radiographic and end-point biomechanical and histologic data. Objective. To analyze histologically the ability of rhBMP-2 to achieve complete arthrodesis between vertebral bodies. Summary of Background Data. Studies using rhBMP for enhancement of anterior interbody fusion have used numerous endpoints. However, systematic histologic evaluation of the fusion has not been conducted. Methods. Twelve sheep underwent single-level anterior lumbar interbody fusion performed with a cylindrical fenestrated titanium interbody fusion device (INTER FIX, Medtronic Sofamor Danek, Inc., Memphis, TN). The device was filled either with rhBMP-2–collagen (n = 6) or autogenous iliac crest bone graft (n = 6). Radiologic evaluation was carried out at 2-month intervals, and all sheep were killed 6 months after surgery. Nondestructive biomechanical testing for stiffness to flexion, extension, and lateral bending moments, un-decalcified histology, and qualitative and quantitative histologic evaluation were performed. Results. Radiographs revealed a bony bridge anterior to the cage in five of six rhBMP-2-treated animals, whereas it was present only in one of five in the autogenous bone graft group. Segments treated with rhBMP-2 were 20% stiffer in flexion than autograft-treated segments at 6 months. Six of six in the rhBMP-2 group and two of six in the autograft group showed complete fusion. There was a significantly higher rate of bony continuity observed at the fenestrations of the rhBMP-2 group. Three times more number of cage fenestrations in the rhBMP-2 group demonstrated “all-bone” when compared with the autograft group (P \u3c 0.001). Further, the scar tissue in and around the autograft-treated cages was 16-fold more (P \u3c 0.01) than that seen for rhBMP-2-treated cages. Conclusions. The study demonstrates that rhBMP-2 can lead to earlier radiologic fusion and a more consistent increased stiffness of the segments when compared with autograft in sheep anterior lumbar interbody fusion. Furthermore, a three times higher histologic fusion rate is attainable with significantly reduced fibrous tissue around the implant when rhBMP-2 is used

Tests of the Standard Model Using Muon Polarization Asymmetries in Kaon Decays

We have examined the physics and the experimental feasibility of studying various kaon decay processes in which the polarization of a muon in the final state is measured. Valuable information on CP violation, the quark mixing (CKM) matrix, and new physics can be obtained from such measurements. We have considered muon polarization in K_L to mu+ mu- and K to pi mu+ mu- decays. Although the effects are small, or difficult to measure because of the small branching ratios involved, these studies could provide clean measurements of the CKM parameters. The experimental difficulty appears comparable to the observation of K to pi nu barnu. New sources of physics, involving non-standard CP violation, could produce effects observable in these measurements. Limits from new results on the neutron and electron electric dipole moment, and epsilon-prime over epsilon in neutral kaon decays, do not eliminate certain models that could contribute to the signal. A detailed examination of muon polarization out of the decay plane in KMU3 and radiative KMU2 decays also appears to be of interest. With current kaon beams and detector techniques, it is possible to measure the T-violating polarization for KMU3 with uncertainties approaching 0.0001. This level of sensitivity would provide an interesting probe of new physics.Comment: 24 pages, 3 figures, To be published in the International Journal of Modern Physics

Large Non-perturbative Effects of Small \Delta m^2_{21}/\Delta m^2_{31} and \sin \theta_{13} on Neutrino Oscillation and CP Violation in Matter

In the framework of three generations, we consider the CP violation in neutrino oscillation with matter effects. At first, we show that the non-perturbative effects of two small parameters, \Delta m_{21}^2/\Delta m_{31}^2 and \sin \theta_{13}, become more than 50% in certain ranges of energy and baseline length. This means that the non-perturbative effects should be considered in detailed analysis in the long baseline experiments. Next, we propose a method to include these effects in approximate formulas for oscillation probabilities. Assuming the two natural conditions, \theta_{23}=45^\circ and the fact that the matter density is symmetric, a set of approximate formulas, which involve the non-perturbative effects, has been derived in all channels.Comment: 25 pages, 4 figures, version to appear in JHE

Radiative Mechanism to Light Fermion Masses in the MSSM

In a previous work we have showed that the ${\cal Z}_{2}^{\prime}$ Symmetry, imply that the light fermions, the electron and the quarks, $u,d$ and $s$, get their masses only at one loop level. Here, we considere the more general hypothesis for flavour mixing in the sfermion sector in the MSSM. Then, we present our results to the masses of these light fermions and as a final result we can explain why the $s$ quark is heavier than the $u,d$ quarks. This mechanism is in agrement with the experimental constraint on the sfermion's masses values.Comment: 22 pages, 8 figures, TeX mistakes corrected, accepted for publication in JHE

From parameter space constraints to the precision determination of the leptonic Dirac CP phase

We discuss the precision determination of the leptonic Dirac CP phase $\delta_{CP}$ in neutrino oscillation experiments, where we apply the concept of ``CP coverage''. We demonstrate that this approach carries more information than a conventional CP violation measurement, since it also describes the exclusion of parameter regions. This will be very useful for next-generation long baseline experiments where for sizable $\sin^2 2 \theta_{13}$ first constraints on $\delta_{CP}$ can be obtained. As the most sophisticated experimental setup, we analyze neutrino factories, where we illustrate the major difficulties in their analysis. In addition, we compare their potential to the one of superbeam upgrades and next-generation experiments, which also includes a discussion of synergy effects. We find a strong dependence on the yet unknown true values of $\sin^2 2 \theta_{13}$ and $\delta_{CP}$, as well as a strong, non-Gaussian dependence on the confidence level. A systematic understanding of the complicated parameter dependence will be given. In addition, it is shown that comparisons of experiments and synergy discussions do in general not allow for an unbiased judgment if they are only performed at selected points in parameter space. Therefore, we present our results in dependence of the yet unknown true values of $\sin^2 2 \theta_{13}$ and $\delta_{CP}$. Finally we show that for $\delta_{CP}$ precision measurements there exist simple strategies including superbeams, reactor experiments, superbeam upgrades, and neutrino factories, where the crucial discriminator is $\sin^2 2 \theta_{13} \sim 10^{-2}$.Comment: 32 pages, 9 figure

Neutrino oscillation physics at an upgraded CNGS with large next generation liquid Argon TPC detectors

The determination of the missing $U_{e3}$ element (magnitude and phase) of the PMNS neutrino mixing matrix is possible via the detection of \numu\to\nue oscillations at a baseline $L$ and energy $E$ given by the atmospheric observations, corresponding to a mass squared difference $E/L \sim \Delta m^2\simeq 2.5\times 10^{-3} eV^2$. While the current optimization of the CNGS beam provides limited sensitivity to this reaction, we discuss in this document the physics potential of an intensity upgraded and energy re-optimized CNGS neutrino beam coupled to an off-axis detector. We show that improvements in sensitivity to $\theta_{13}$ compared to that of T2K and NoVA are possible with a next generation large liquid Argon TPC detector located at an off-axis position (position rather distant from LNGS, possibly at shallow depth). We also address the possibility to discover CP-violation and disentangle the mass hierarchy via matter effects. The considered intensity enhancement of the CERN SPS has strong synergies with the upgrade/replacement of the elements of its injector chain (Linac, PSB, PS) and the refurbishing of its own elements, envisioned for an optimal and/or upgraded LHC luminosity programme.Comment: 37 pages, 20 figure

Physics at a Fermilab Proton Driver

This report documents the physics case for building a 2 MW, 8 GeV superconducting linac proton driver at Fermilab.Comment: 52 pages, 15 figure

Secondary Beam Monitors for the NuMI Facility at FNAL

The Neutrinos at the Main Injector (NuMI) facility is a conventional neutrino beam which produces muon neutrinos by focusing a beam of mesons into a long evacuated decay volume. We have built four arrays of ionization chambers to monitor the position and intensity of the hadron and muon beams associated with neutrino production at locations downstream of the decay volume. This article describes the chambers' construction, calibration, and commissioning in the beam.Comment: Accepted for publication in Nucl. Instr. Meth.