1,115 research outputs found
Microwave emission by nonlinear crystals irradiated with a high-intensity, mode-locked laser
We report on the experimental investigation of the efficiency of some
nonlinear crystals to generate microwave (RF) radiation as a result of optical
rectification (OR) when irradiated with intense pulse trains delivered by a
mode-locked laser at nm. We have investigated lithium triborate (LBO),
lithium niobate (LiNbO), zinc selenide (ZnSe), and also potassium titanyl
orthophosphate (KTP) for comparison with previous measurements. The results are
in good agreement with the theoretical predictions based on the form of the
second-order nonlinear susceptibility tensor. For some crystals we investigated
also the second harmonic generation (SHG) to cross check the theoretical model.
We confirm the theoretical prediction that OR leads to the production of higher
order RF harmonics that are overtones of the laser repetition rate.Comment: accepted for publication in Journal of Optics, in pres
Cathodo- and radioluminescence of Tm:YAG and Nd:YAG in an extended wavelength range
We have studied the cathodo- and radioluminescence of Nd:YAG and of Tm:YAG
single crystals in an extended wavelength range up to m in view
of developing a new kind of detector for low-energy, low-rate energy deposition
events. Whereas the light yield in the visible range is as large as photons/MeV, in good agreement with literature results, in the
infrared range we have found a light yield photons/MeV, thereby proving that ionizing radiation is particularly
efficient in populating the low lying levels of rare earth doped crystals.Comment: submitted for publication in Journal of Luminescenc
A new technique for infrared scintillation measurements
We propose a new technique to measure the infrared scintillation light yield
of rare earth (RE) doped crystals by comparing it to near UV-visible
scintillation of a calibrated Pr:(LuY)AlO
sample. As an example, we apply this technique to provide the light yield in
visible and infrared range up to \SI{1700}{nm} of this crystal.Comment: submitted to NIM
Laser induced fluorescence for axion dark matter detection: a feasibility study in YLiF:Er
We present a detection scheme to search for QCD axion dark matter, that is
based on a direct interaction between axions and electrons explicitly predicted
by DFSZ axion models. The local axion dark matter field shall drive transitions
between Zeeman-split atomic levels separated by the axion rest mass energy . Axion-related excitations are then detected with an upconversion scheme
involving a pump laser that converts the absorbed axion energy (
hundreds of eV) to visible or infrared photons, where single photon
detection is an established technique. The proposed scheme involves rare-earth
ions doped into solid-state crystalline materials, and the optical transitions
take place between energy levels of electron configuration. Beyond
discussing theoretical aspects and requirements to achieve a cosmologically
relevant sensitivity, especially in terms of spectroscopic material properties,
we experimentally investigate backgrounds due to the pump laser at temperatures
in the range K. Our results rule out excitation of the upper Zeeman
component of the ground state by laser-related heating effects, and are of some
help in optimizing activated material parameters to suppress the
multiphonon-assisted Stokes fluorescence.Comment: 8 pages, 5 figure
Role of magnetic resonance in characterising extrahepatic cholangiocarcinomas
PURPOSE: The purpose of this study was to evaluate the accuracy of magnetic resonance (MR) in correctly locating and characterising biliary strictures in patients affected by extrahepatic cholangiocarcinoma, identify findings suggestive of the disease, identify lesions with similar MR features and possible criteria for differential diagnosis and establish prospective MR accuracy in diagnosis of malignant obstruction of extrahepatic bile ducts. MATERIALS AND METHODS: We retrospectively reviewed the MR examinations of 39 patients affected by extrahepatic cholangiocarcinoma confirmed by histology or cytology. The studies were evaluated for the following parameters: site of obstruction (hilar, proximal or distal), presence of intra- or extrahepatic dilation of bile ducts, morphology of ductal stenosis (gradual tapering or abrupt ending), morphology of the lesion (mass like or circumferential), dimension, signal intensity before contrast medium administration and lesion enhancement after administration of contrast medium. Finally, we assessed the most useful sequence for the diagnosis. In order to evaluate MR accuracy in the diagnosis of malignant obstruction of extrahepatic bile ducts, we prospectively reviewed MR examinations of 74 patients affected by obstructive jaundice (55 malignant lesions and 19 inflammatory lesions). MR diagnosis was compared with histology or cytology considered as the gold standard. RESULTS: MR allowed identification and localisation of 41/41 extrahepatic cholangiocarcinomas. Fifty-four percent of the lesions showed gradual duct tapering; the remaining lesions showed an abrupt ending. Fifty-six percent of the lesions appeared as a circumferential thickening (infiltrative growth); the remaining lesions had a mass-like appearance (expansile growth). Most lesions were hypo- (49%) or isointense (49%) in T1-weighted sequences and hyper- (49%) or isointense (51%) in T2-weighted sequences. Ninety-five percent of the lesions did not enhance significantly in the arterial phase while 98% showed late enhancement (10 min). The most diagnostic sequence (in 76% of cases) was the late-phase gradient-echo (GRE) T1 fat-saturated sequence. MR had good sensitivity (91%) but poor specificity (47%) in characterising stenosis as malignant, given the large number (10/19) of benign lesions evaluated as neoplastic lesions. CONCLUSIONS: MR almost always identified the cause of stenosis and suggested its neoplastic nature if it exhibited a mass-like appearance (extraductal or growing into the choledochus). On the other hand, lesions with parietal thickening, particularly if smaller than 1 cm, require endoscopic cytology or histology because of the high risk of unnecessary procedures for benign lesions
Particle detection through the quantum counter concept in YAG:Er
We report about a novel scheme for particle detection based on the infrared
quantum counter concept. Its operation consists of a two-step excitation
process of a four level system, that can be realized in rare earth-doped
crystals when a cw pump laser is tuned to the transition from the second to the
fourth level. The incident particle raises the atoms of the active material
into a low lying, metastable energy state, triggering the absorption of the
pump laser to a higher level. Following a rapid non-radiative decay to a
fluorescent level, an optical signal is observed with a conventional detectors.
In order to demonstrate the feasibility of such a scheme, we have investigated
the emission from the fluorescent level S (540 nm band) in an
Er-doped YAG crystal pumped by a tunable titanium sapphire laser when it
is irradiated with 60 keV electrons delivered by an electron gun. We have
obtained a clear signature this excitation increases the
metastable level population that can efficiently be exploited to generate a
detectable optical signal
Cystic tumors of the pancreas
Cystic tumors of the pancreas are less frequent than solid lesions and are often detected incidentally, as many of these lesions are small and asymptomatic. However, they may be associated with pancreatitis or have malignant potential. With advancements in diagnostic imaging, cystic lesions of the pancreas are being detected with increasing frequency. Many lesions can cause a pancreatic cyst, most being non-neoplastic while approximately 10% are cystic tumors, ranging from benign to highly malignant tumors. With increasing experience it is becoming clear that the prevalence of pseudocyst among cystic lesions of the pancreas is lower than usually presumed. A presumptive diagnosis of pseudocyst based on imaging appearance alone can cause a diagnostic error, and neoplastic cysts of the pancreas are particularly susceptible to this misdiagnosis, which can result in inappropriate treatment. Cystic tumors of the pancreas are formed by serous or mucinous structures showing all stages of cellular differentiation. According to the WHO classification, they can be subdivided on the basis of their histological type and biological behavior into benign tumors, borderline tumors, and malignant tumors. Cystic pancreatic tumors can be subdivided into peripheral (serous cystadenomas, mucinous cystic tumors, solid and papillary epithelial neoplasms, cystic islet cell tumors), which do not communicate with the main pancreatic duct, and ductal tumors (mucinous tumor), according to their site of origin. On the basis of imaging criteria alone, it can be very difficult to differentiate non-tumoral cystic lesions from neoplastic ones. The management of these patients is complex, and it is important to correlate imaging findings with knowledge of the patient's symptoms and of the natural history and predictors of malignancy in pancreatic cysts
Contrast agents for hepatic MRI
Liver specific contrast media (LSCM) can be subdivided according to different modalities of hepatic distribution: exclusive distribution to the hepatocellular compartment can be obtained using CM which accumulate within the hepatocytes after slow infusion; other CM demonstrate combined perfusion and hepatocyte-selective properties, with an initial distribution to the vascular-interstitial compartment (in an analogous manner to that of the conventional extracellular CM), thereafter, a fraction of the injected dose is taken up into the hepatocytes causing an increase in the signal intensity of the hepatic tissue. The use of the superparamagnetic effect of iron oxide particles is based on distribution in the reticuloendothelial system (RES), usually well represented in the normal parenchyma as well as in benign hepatocellular lesions, and absent in most malignant lesions. It is necessary to have an in-depth knowledge of either the biological and histological characteristics of focal liver lesions (FLL) or the enhancement mechanism of LSCM to gain significant accuracy in the differential diagnosis of FLL. Dynamic contrast-enhanced MRI is an important tool in the identification and characterization of FLL. With LSCM it is possible to differentiate benign from malignant lesions and hepatocellular lesions from non hepatocellular lesions with high accuracy. To understand the contrast behaviour after injection of LSCM it is necessary to correlate the contrast enhancement with both the biological and histological findings of FLL
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