12 research outputs found

    Fibonacci and k Lucas Sequences as Series of Fractions.

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    In this paper, we defined new relationship between k Fibonacci and k Lucas sequences using continued fractions and series of fractions, this approach is different and never tried in k Fibonacci sequence literature

    Prospective Hybrid Molecules with Dual Anti-Viral and Anti-Thrombotic Activity Against the SARS-CoV-2 Infection and Its Associated Complications Employing in Silico Studies

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    Covid-19, a SARS-CoV virus-based disease, was identified in Wuhan, China, in December 2019. Initially, it was considered just an infection of the respiratory system, but due to its transmittable nature, it was declared a pandemic. A variety of treatment options were implemented, including antivirals like remdesvir, favipiravir along with vitamins and antioxidants. Further investigations revealed that the Covid-19 infection results in thrombotic cardiovascular complications, which are the major concern for the increased mortality associated with this disease. This study investigates the in Silico design of hybrid molecules with antiviral and an-tithrombotic properties. A docking study was performed using Autodock Vina software, and binding energies of the designed compounds were determined for papain-like protease (PDB: 3E9S) and 3-chymotrypsin-like cysteine protease (PDB: 6LU7). The docked poses and amino acids interactions were verified using Biovia Discovery studio 4.5. The binding energies of all designed compounds were compared with the standards, Compound RL1 (2-(5-(3-carbamoyl-1H-1,2,4-triazol-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)-carbonyl)amino)(hydroxy)methyl)carbamoyl)phenyl acetate) and Compound FL2 (8-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxochroman-6-yl(2-(6-flouro-3-oxo-3,4-dihydropyrazine-2-carboxamido)-1-hydroxy-3-phenylpropyl)carbamate) proved to be promising agents with strong binding interactions. Hybrid molecules that inhibit viral replication, possibly as transition state inhibitors, can be investigated further for use in the treatment of SARS-Co-V infection and its associated complications

    On the properties of generalized Fibonacci like polynomials

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    On the properties of generalized multiplicative coupled fibonacci sequence of rth order

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    A Review on Automatic Door Opening Techniques and Methods for Product Testing

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    This paper is reviewing the different techniques and methods used for a Refrigerator door opening for product testing. This System will be used for the replicating customeruses pattern of refrigerator at test lab, to evaluate refrigerators actual field performance, during development stage of the product. Due to resource optimization, safety, reduced operating cost and lead time, accuracy in repeated task, the automation ishighly recommended in the industries. Comparison for suitable techniques for this system are described in this paper, also to evaluatefurther,proposedsystemisdescribedinbrief

    Correlating in-plane strength anisotropy with its microstructural counterpart for a hot rolled line pipe steel

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    The present study focuses on the microstructural entities, emphasizing the role of precipitates on the in-plane directional tensile responses, including the strain hardening behaviour of a hot rolled X-65 Line pipe graded steel. Tensile samples have been prepared from four different directions lying on the RD-TD (rolling direction-transverse direction) plane at the varying angle of 0°, 30°, 60°, and 90° with respect to the RD of the hot-rolled plate. Superior mechanical properties have been evidenced in the 90° sample compared to other orientations in terms of maintaining yield continuity and better strength-ductility combination. The yielding behaviour and tensile response have been explained from the viewpoint of grain/grain boundary characteristics, dislocation-precipitation interaction, and elasto-plastic incompatibility across grain boundaries. The role of interaction of dislocations with fine precipitates along with the Elastic Modulus (EM) and Schmid Factor (SF) differences across high angle grain boundaries (HAGBs) have been found to be significant in determining the superiority of the mechanical properties of 90° sample
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