753 research outputs found

    Volume 20 Index

    Get PDF

    Rethinking Principals of Comparative Fault in Light of California\u27s Proposition 51

    Get PDF

    Amidated Dopamine Neuron Stimulating Peptide Restoration of Mitochondrial Activity

    Get PDF
    The present invention relates to the use of novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), for treating brain diseases and injuries that result in dopaminergic deficiencies and mitochodrial dysfunction, e.g., reduced complex I enzyme activity

    Method of Treating Parkinson\u27s Disease in Humans by Convection-Enhanced Infusion of Glial Cell-Line Derived Neurotrophic Factor to the Putamen

    Get PDF
    A method of treating Parkinson\u27s disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or more implantable pumps wherein the flow rate is pulsed

    Amidated Dopamine Neuron Stimulating Peptides for CNS Dopaminergic Upregulation

    Get PDF
    The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or Amidated Dopamine Neuron Stimulating peptides (ADNS peptides) ), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies

    Method of Treating Parkinson\u27s Disease in Humans by Convection-Enhanced Infusion of Glial Cell-Line Derived Neurotrophic Factor to the Putamen

    Get PDF
    A method of treating Parkinson\u27s disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal multiport brain catheters connected to one or more implantable pumps wherein the flow rate is pulsed
    • 

    corecore