Detecting and monitoring arrhythmia recurrence following catheter ablation of atrial fibrillation.

Atrial fibrillation (AF) is the most common arrhythmia prompting clinical presentation, is associated with significant morbidity and mortality. The incidence and prevalence of this arrhythmia is expected to grow significantly in the coming decades. Of the available pharmacologic and non-pharmacologic treatment options, the fastest growing and most intensely studied is catheter-based ablation therapy for AF. Given the varying success rates for AF ablation, the increasingly complex factors that need to be taken into account when deciding to proceed with ablation, as well as varying definitions of procedural success, accurate detection of arrhythmia recurrence and its burden is of significance. Detecting and monitoring AF recurrence following catheter ablation is therefore an important consideration. Multiple studies have demonstrated the close relationship between the intensity of rhythm monitoring with wearable ambulatory cardiac monitors, or implantable cardiac rhythm monitors and the detection of arrhythmia recurrence. Other studies have employed algorithms dependent on intensive monitoring and arrhythmia detection in the decision tree on whether to proceed with repeat ablation or medical therapy. In this review, we discuss these considerations, types of monitoring devices, and implications for monitoring AF recurrence following catheter ablation

Hardware and software status of QCDOC

QCDOC is a massively parallel supercomputer whose processing nodes are based on an application-specific integrated circuit (ASIC). This ASIC was custom-designed so that crucial lattice QCD kernels achieve an overall sustained performance of 50% on machines with several 10,000 nodes. This strong scalability, together with low power consumption and a price/performance ratio of $1 per sustained MFlops, enable QCDOC to attack the most demanding lattice QCD problems. The first ASICs became available in June of 2003, and the testing performed so far has shown all systems functioning according to specification. We review the hardware and software status of QCDOC and present performance figures obtained in real hardware as well as in simulation.Comment: Lattice2003(machine), 6 pages, 5 figure

Vector Meson Dominance as a first step in a systematic approximation: the pion vector form factor

Pade Approximants can be used to go beyond Vector Meson Dominance in a systematic approximation. We illustrate this fact with the case of the pion vector form factor and extract values for the first two coefficients of its Taylor expansion. Pade Approximants are shown to be a useful and simple tool for incorporating high-energy information, allowing an improved determination of these Taylor coefficients.Comment: 13 pages, 7 figure

The static potential: lattice versus perturbation theory in a renormalon-based approach

We compare, for the static potential and at short distances, perturbation theory with the results of lattice simulations. We show that a renormalon-dominance picture explains why in the literature sometimes agreement, and another disagreement, is found between lattice simulations and perturbation theory depending on the different implementations of the latter. We also show that, within a renormalon-based scheme, perturbation theory agrees with lattice simulations.Comment: 18 pages, 11 figures, lattice data of Necco and Sommer introduced, references added, some lengthier explanations given, physical results unchange

Registration of retinal images from Public Health by minimising an error between vessels using an affine model with radial distortions

In order to estimate a registration model of eye fundus images made of an affinity and two radial distortions, we introduce an estimation criterion based on an error between the vessels. In [1], we estimated this model by minimising the error between characteristics points. In this paper, the detected vessels are selected using the circle and ellipse equations of the overlap area boundaries deduced from our model. Our method successfully registers 96 % of the 271 pairs in a Public Health dataset acquired mostly with different cameras. This is better than our previous method [1] and better than three other state-of-the-art methods. On a publicly available dataset, ours still better register the images than the reference method

Studies on growth rates in pigs and the effect of birth weight

End of project reportThe purpose of this study was to assess some environmental and management factors that affect growth performance on commercial pig units. In experiment 1, a survey was carried out on 22 pig units of known growth performance in south-west Ireland to compare management factors between those showing poor and good growth rates. Low growth rate appears to be due to the cumulative effect of a combination of factors. Experiment 2 was conducted to determine the effects of providing an additional feeder on performance of weaned piglets. No benefits were recorded. Feed consumed from the additional feeder was a replacement for feed that otherwise would have been consumed from the control hopper feeder. Experiment 3 was designed to determine if pig performance and efficiency of growth were affected by weight at birth and at weaning. Lightweight pigs showed inferior growth performance up to the finisher period. Although they compensated some of the inferior growth towards the time of slaughter, they never reached the weights of the heavy birth-weight animals. Males were either significantly heavier or tended to be heavier than females throughout. There was no significant difference between the sexes in the number of days to slaughter. Light and heavy pigs did not differ in the levels of IGF-1 in their blood plasma; however lightweight pigs had significantly lower IgG preweaning. Experiment 4 aimed to determine whether piglet birth weight influenced growth performance, plasma IGF-1 concentrations and muscle fibre characteristics at day 42 of life. At slaughter (Day 42) light birth weight pigs were significantly (P < 0.001) lighter. Plasma IGF-1 concentration was lower by 28% (P=0.06) in light pigs. Muscle fibre cross sectional area and total fibre number were not significantly different between groups. This study should be repeated with bigger numbers

Gravitational Lensing of the X-Ray Background by Clusters of Galaxies

Gravitational lensing by clusters of galaxies affects the cosmic X-ray background (XRB) by altering the observed density and flux distribution of background X-ray sources. At faint detection flux thresholds, the resolved X-ray sources appear brighter and diluted, while the unresolved component of the XRB appears dimmer and more anisotropic, due to lensing. The diffuse X-ray intensity in the outer halos of clusters might be lower than the sky-averaged XRB, after the subtraction of resolved sources. Detection of the lensing signal with a wide-field X-ray telescope could probe the mass distribution of a cluster out to its virialization boundary. In particular, we show that the lensing signature imprinted on the resolved component of the XRB by the cluster A1689, should be difficult but possible to detect out to 8' at the 2-4 sigma level, after 10^6 seconds of observation with the forthcoming AXAF satellite. The lensing signal is fairly insensitive to the lens redshift in the range 0.1<z<0.6. The amplitude of the lensing signal is however sensitive to the faint end slope of the number-flux relation for unresolved X-ray sources, and can thus help constrain models of the XRB. A search for X-ray arcs or arclets could identify the fraction of all faint sources which originate from extended emission of distant galaxies. The probability for a 3 sigma detection of an arclet which is stretched by a factor of about 3 after a 10^6 seconds observation of A1689 with AXAF, is roughly comparable to the fraction of all background X-ray sources that have an intrinsic size of order 1''.Comment: 41 LaTeX pages, 11 postscript figures, 1 table, in AASTeX v4.0 format. To appear in ApJ, April 1, 1997, Vol. 47

Accretion Disk Instabilities, CDM models and their role in Quasar Evolution

We have developed a consistent analytical model to describe the observed evolution of the quasar luminosity function. Our model combines black hole mass distributions based on the Press - Schechter theory of the structure formation in the Universe with quasar luminosity functions resulting from a physics-based emission model that takes into account the time-dependent phenomena occurring in the accretion disks. Quasar evolution and CDM models are mutually constraining, therefore our model gives an estimation of the exponent, n, of the power spectrum, P(k), which is found to be -1.8 < n < -1.6. We were able to reject a generally assumed hypothesis of a constant ratio between Dark Matter Halo and the Black Hole mass, since the observed data could not be fitted under this assumption. We found that the relation between the Dark Matter Halos and Black Hole masses is better described by M_{BH}=M_{DMH}^{0.668}. This model provides a reasonable fit to the observed quasar luminosity function at redshifts higher than ~2.0. We suggest that the disagreement at lower redshift is due to mergers. Based on the agreement at high redshift, we estimated the merger rate at lower redshift, and argue that this rate should depend on the redshift, like (1+z)^3.Comment: 15 pages, 18 figures, Accepted for Publication in Ap

The Fall of the Quasar Population

We derive quantitative predictions of the optical and X-ray luminosity functions (LF) for QSs in the redshift range $z<3$. Based on BH paradigm, we investigate how the accretion is controlled by the surrounding structures, as these grow hierarchically. We argue that for $z < 3$ efficient black hole fueling is triggered by the encounters of a gas-rich host with its companions in a group. The dispersion of the dynamical parameters in the encounters produces a double power-law LF. Strong luminosity evolution (LE) is produced as these encounters deplete the gas supply in the host; an additional, milder density evolution obtains since the interactions become progressively rarer as the groups grow richer but less dense. From the agreement with the optical and the X-ray data, we conclude that the evolution of the bright quasars is articulated in two ways. Earlier than $z~3$ the gas-rich protogalaxies grow by merging, which also induces parallel growth of central holes accreting at Eddington rates. In the later era of group assemblage the host encounters with companions drive onto already existing holes further but meager accretion; these consume the gas in the hosts, and cause supply-limited emissions which are intermittent, go progressively sub-Eddington and peter out. Then other fueling processes come to the foreground; we discuss the faint emissions, especially noticeable in X-rays, which are expected when hosts in the field cannibalize satellite galaxies with their meager gas contents.Comment: 12 pages Latex + 3 EPS figures, ApJ in press, we have corrected the previous printing problems with the style \ca

Exotic and excited-state radiative transitions in charmonium from lattice QCD

We compute, for the first time using lattice QCD methods, radiative transition rates involving excited charmonium states, states of high spin and exotics. Utilizing a large basis of interpolating fields we are able to project out various excited state contributions to three-point correlators computed on quenched anisotropic lattices. In the first lattice QCD calculation of the exotic 1-+ eta_c1 radiative decay, we find a large partial width Gamma(eta_c1 -> J/psi gamma) ~ 100 keV. We find clear signals for electric dipole and magnetic quadrupole transition form factors in chi_c2 -> J/psi gamma, calculated for the first time in this framework, and study transitions involving excited psi and chi_c1,2 states. We calculate hindered magnetic dipole transition widths without the sensitivity to assumptions made in model studies and find statistically significant signals, including a non-exotic vector hybrid candidate Y_hyb? -> eta_c gamma. As well as comparison to experimental data, we discuss in some detail the phenomenology suggested by our results and the extent to which it mirrors that of quark potential models and make suggestions for the interpretation of our results involving exotic quantum numbered states