Introduction: Williams syndrome: A model for the neuroconstructivist approach

This introductory chapter first sets out the purpose of the book, which is to serve as a paradigm for multidisciplinary, neuroconstructivist approaches to a wide range of other syndromes, taking the neurodevelopmental disorder Williams syndrome (WS) as a model syndrome. It then discusses the neuroconstructivist approach to neurodevelopmental disorders. An overview of the subsequent chapters is also presented

The effect of pictorial depth information on projected size judgments.

When full depth cues are available, size judgments are dominated by physical size. However, with reduced depth cues, size judgments are influenced less by physical size and more by projected size. By manipulating monocularly presented pictorial depth cues only, in this study we reduced depth cues further than had previous size judgment studies. Participants were presented monocularly with two shapes against a background of zero (control), one, two, or three pictorial depth cues. Each cue was added progressively in the following order: height in the visual field, linear perspective, and texture gradient. Participants made a same/different judgment regarding the projected size of the two shapes (i.e., ignoring any depth cues). As was expected, accuracy increased and response times decreased as the ratio between the projected size of the two shapes increased (range of projected size ratios, 1:1-1:5). In addition, with the exception of the larger size ratios (1:4 and 1:5), detection of projected size difference grew poorer as depth cues were added. One- and two-cue conditions had the most weighting in this performance decrement, with little weighting from the three-cue condition. We conclude that even minimal depth information is difficult to inhibit, which indicates that depth perception requires little focused attention

Reconsidering the Reading Motivation of Adolescent Latinx Multilingual Learners

In this article, the authors reconsider traditional concepts of reading motivation to arrive at practical teaching approaches to enhance the reading motivation, engagement, and achievement of adolescent Latinx multilingual leanrers in both traditonal and online learning environments. Focusing on the bioecological Process-Person-Context-Time Model and Expectancy-Value Theory, specific factors that influence the reading motivation of Latinx multilingual learners are discussed along with practical instructional strategies for both traditional and online/virtual classrooms. They also highlight the utility of a strengths-based pedagogy vis-a-vis the growing inequities that surround Latinx multilingual leaners. The paper concludes by offering recommendations for reading motivation practice

The Kuramoto model: A simple paradigm for synchronization phenomena

Synchronization phenomena in large populations of interacting elements are the subject of intense research efforts in physical, biological, chemical, and social systems. A successful approach to the problem of synchronization consists of modeling each member of the population as a phase oscillator. In this review, synchronization is analyzed in one of the most representative models of coupled phase oscillators, the Kuramoto model. A rigorous mathematical treatment, specific numerical methods, and many variations and extensions of the original model that have appeared in the last few years are presented. Relevant applications of the model in different contexts are also included

Genetic contributions to visuospatial cognition in Williams syndrome: insights from two contrasting partial deletion patients

Background Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23. WS is characterised by an uneven cognitive profile, with serious deficits in visuospatial tasks in comparison to relatively proficient performance in some other cognitive domains such as language and face processing. Individuals with partial genetic deletions within the WS critical region (WSCR) have provided insights into the contribution of specific genes to this complex phenotype. However, the combinatorial effects of different genes remain elusive. Methods We report on visuospatial cognition in two individuals with contrasting partial deletions in the WSCR: one female (HR), aged 11 years 9 months, with haploinsufficiency for 24 of the WS genes (up to GTF2IRD1), and one male (JB), aged 14 years 2 months, with the three most telomeric genes within the WSCR deleted, or partially deleted. Results Our in-depth phenotyping of the visuospatial domain from table-top psychometric, and small- and large-scale experimental tasks reveal a profile in HR in line with typically developing controls, albeit with some atypical features. These data are contrasted with patient JB’s atypical profile of strengths and weaknesses across the visuospatial domain, as well as with more substantial visuospatial deficits in individuals with the full WS deletion. Conclusions Our findings point to the contribution of specific genes to spatial processing difficulties associated with WS, highlighting the multifaceted nature of spatial cognition and the divergent effects of genetic deletions within the WSCR on different components of visuospatial ability. The importance of general transcription factors at the telomeric end of the WSCR, and their combinatorial effects on the WS visuospatial phenotype are also discussed

A Geometric characterization of Finsler manifolds of constant curvature K

We prove that a Finsler manifold 𝔽m is of constant curvature K=1 if and only if the unit horizontal Liouville vector field is a Killing vector field on the indicatrix bundle IM of 𝔽m

A higher dietary restraint is associated with higher BMI: a cross-sectional study in college students

Background: College students tend to have eating and lifestyle habits that can lead to weight gain. Paradoxically, weight gain could also lead to calorie restriction, a practice that is common among those who are concerned about their body weight. Thus, the objective of this study was to investigate the association between habits related to overweight and obesity and dietary intake, physical activity, and BMI among college students. Methodology: One hundred ninety-two participants (18-26 years; 75% female) were included in this crosssectional study. Participants completed the 'habits related to overweight and obesity questionnaire' which evaluates five dimensions: the concern about caloric intake, healthy eating, physical activity, alcohol consumption, and eating for psychological well-being. Additionally, anthropometric parameters, dietary intake, and physical activity were evaluated. Linear regression models were used to examine the associations between outcome and exposure variables. Results: Higher concern about caloric intake was associated with higher BMI (1.05 kg/m2 [95%CI: 0.58, 1.51]), but lower energy (-312.2 kcal/day [95%CI: -404.6, -219.8]) and fat intake (-1.88% [95%CI: -2.94, -0.83]). Furthermore, healthy eating was related to better diet quality 0.96 [95%CI: 0.47,1.44] and lower energy intake (-231.4 kcal/day [95%CI: -367.7, -95.2]). Meanwhile, higher scores in the physical activity dimension were associated with better diet quality (0.41 [95%CI: 0.16,0.66]). Conclusions: College students with the highest dietary restraint had the greatest BMI and the lowest energy and fat intake. Our results highlight the importance of promoting healthy behaviors among college students.</p