389 research outputs found
Source-oriented model for air pollutant effects on visibility
A source-oriented model for air pollutant effects on visibility has been developed that can compute light scattering, light extinction, and estimated visual range directly from data on gas phase and primary particle phase air pollutant emissions from sources. The importance of such a model is that it can be used to compute the effect of emission control proposals on visibility-related parameters in advance of the adoption of such control programs. The model has been assembled by embedding several aerosol process modules within the photochemical trajectory model previously developed for aerosol nitrate concentration predictions by Russell et al. [1983] and Russell and Cass [1986]. These modules describe the size distribution and chemical composition of primary particle emissions, the speciation of organic vapor emissions, atmospheric chemical reactions, transport of condensible material between the gas and the particle phases, fog chemistry, dry deposition, and atmospheric light scattering and light absorption. Model predictions have been compared to observed values using 48-hour trajectories arriving at Claremont, California, at each hour of August 28, 1987, during the Southern California Air Quality Study. The predicted fine particle concentration averages 62 μg m^(−3) compared to an observed value of 61 μg m^(−3), while predicted PM_(10) concentrations average 102 μg m^(−3) compared to an observed average of 97 μg m^(−3). The size distribution and chemical composition predictions for elemental carbon, sulfate, and sodium ion agree with observations to within plus or minus a few micrograms per cubic meter, while ammonium and nitrate concentrations are underpredicted by the base case model by 3 to 7 μg m^(−3) on average. Light-scattering coefficient values are calculated from the predicted aerosol size distribution and refractive index, and the model predictions agree with measured values on average to within 19%. The advantages and limitations of the modeling procedure are discussed
Patent Valuation: Aren’t We Forgetting Something? Making the Case for Claims Analysis in Patent Valuation by Proposing a Patent Valuation Method and a Patent-Specific Discount Rate Using the CAPM
Patent Valuation: Aren’t We Forgetting Something? Making the Case for Claims Analysis in Patent Valuation by Proposing a Patent Valuation Method and a Patent-Specific Discount Rate Using the CAPM
Aerosol optical properties during INDOEX based on measured aerosol particle size and composition
The light scattering and light absorption as a function of wavelength and relative humidity due to aerosols measured at the Kaashidhoo Climate Observatory in the Republic of the Maldives during the INDOEX field campaign has been calculated. Using size-segregated measurements of aerosol chemical composition, calculated light scattering and absorption has been evaluated against measurements of light scattering and absorption. Light scattering coefficients are predicted to within a few percent over relative humidities of 20–90%. Single scattering albedos calculated from the measured elemental carbon size distributions and concentrations in conjunction with other aerosol species have a relative error of 4.0% when compared to measured values. The single scattering albedo for the aerosols measured during INDOEX is both predicted and observed to be about 0.86 at an ambient relative humidity of 80%. These results demonstrate that the light scattering, light absorption, and hence climate forcing due to aerosols over the Indian Ocean are consistent with the chemical and physical properties of the aerosol at that location
Expression of the alpha subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells Synthesis and secretion of an enzymatically inactive homodimer
AbstractIn this paper, we report the expression of PPHα in the polarized cell line MDCK (Madin Darby canine kidney). In these cells, the enzyme was synthesized m an inactive profonn, which upon treatment with trypsin was activated. The enzyme isolated from cell extracts was core-glycosylated and appeared to be retained in the ER as a homodimer. No PPHα was detectable on the surface of intact cells by immunofluoreseence. However, a complex glycosylated soluble but inactive form was present in the culture medium, suggesting that proteolytic removal of the C-terminal membrane anchoring peptide leads to the secretion of PPHα
Tropical thin cirrus and relative humidity observed by the Atmospheric Infrared Sounder
International audienceGlobal observations of cloud and humidity distributions in the upper troposphere within all geophysical conditions are critically important in order to monitor the present climate and to provide necessary data for validation of climate models to project future climate change. Towards this end, tropical oceanic distributions of thin cirrus optical depth (?), effective diameter (De), and relative humidity with respect to ice (RHi) within cirrus (RHic) are simultaneously derived from the Atmospheric Infrared Sounder (AIRS). Corresponding increases in De and cloud temperature are shown for cirrus with ?>0.25 that demonstrate quantitative consistency to other surface-based, in situ and satellite retrievals. However, inferred cirrus properties are shown to be less certain for increasingly tenuous cirrus. In-cloud supersaturation is observed for 8?12% of thin cirrus and is several factors higher than all-sky conditions; even higher frequencies are shown for the coldest and thinnest cirrus. Spatial and temporal variations in RHic correspond to cloud frequency while regional variability in RHic is observed to be most prominent over the N. Indian Ocean basin. The largest cloud/clear sky RHi anomalies tend to occur in dry regions associated with vertical descent in the sub-tropics, while the smallest occur in moist ascending regions in the tropics. The characteristics of RHic frequency distributions depend on ? and a peak frequency is located between 60?80% that illustrates RHic is on average biased dry. The geometrical thickness of cirrus is typically less than the vertical resolution of AIRS temperature and specific humidity profiles and thus leads to the observed dry bias, shown with coincident cloud vertical structure obtained from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO). The joint distributions of thin cirrus microphysics and humidity derived from AIRS provide unique and important regional and global-scale insights on upper tropospheric processes not available from surface, in situ, and other contemporary satellite observing platforms
Observation of Sulfate Aerosols and SOâ‚‚ From the Sarychev Volcanic Eruption Using Data From the Atmospheric Chemistry Experiment (ACE)
[1] Infrared spectra measured by the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) on the SCISAT satellite were used to analyze the Sarychev volcanic aerosol after the eruption in June 2009. Evidence of the Sarychev eruptions was first detected in July 2009 from enhanced SO2 concentrations and atmospheric extinction. By February 2010, the atmosphere had returned to pre-Sarychev conditions. In July 2009, the volcanic plume was found between 8.5 km and 17.5 km in altitude at mid- and high latitudes (55°N–70°N). The first SO2 and sulfate aerosol retrievals carried out using the infrared solar occultation spectra recorded with the ACE-FTS are presented here. The size distribution parameters, the aerosol volume slant column and the composition of the sulfate aerosol were obtained by using a least squares algorithm. The maximum volume slant column of the aerosols was found to be 850 μm3 cm−3 km, which results in an approximate aerosol loading of 3 μm3 cm−3. One month after the eruption, the composition of the aerosols providing the best-fit is a 75% sulfuric acid-water solution with an effective radius (Reff) of 0.1–0.3 μm
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Intercomparison Methods for Satellite Measurements of Atmospheric Composition: Application to Tropospheric Ozone from TES and OMI
We analyze the theoretical basis of three different methods to validate and intercompare satellite measurements of atmospheric composition, and apply them to tropospheric ozone retrievals from the Tropospheric Emission Spectrometer (TES) and the Ozone Monitoring Instrument (OMI). The first method (in situ method) uses in situ vertical profiles for absolute instrument validation; it is limited by the sparseness of in situ data. The second method (CTM method) uses a chemical transport model (CTM) as an intercomparison platform; it provides a globally complete intercomparison with relatively small noise from model error. The third method (averaging kernel smoothing method) involves smoothing the retrieved profile from one instrument with the averaging kernel matrix of the other; it also provides a global intercomparison but dampens the actual difference between instruments and adds noise from the a priori. We apply the three methods to a full year (2006) of TES and OMI data. Comparison with in situ data from ozonesondes shows mean positive biases of 5.3 parts per billion volume (ppbv) (10%) for TES and 2.8 ppbv (5%) for OMI at 500 hPa. We show that the CTM method (using the GEOS-Chem CTM) closely approximates results from the in situ method while providing global coverage. It reveals that differences between TES and OMI are generally less than 10 ppbv (18%), except at northern mid-latitudes in summer and over tropical continents. The CTM method further allows for CTM evaluation using both satellite observations. We thus find that GEOS-Chem underestimates tropospheric ozone in the tropics due to possible underestimates of biomass burning, soil, and lightning emissions. It overestimates ozone in the northern subtropics and southern mid-latitudes, likely because of excessive stratospheric influx of ozone.Earth and Planetary SciencesEngineering and Applied Science
The SFXC software correlator for Very Long Baseline Interferometry: Algorithms and Implementation
In this paper a description is given of the SFXC software correlator,
developed and maintained at the Joint Institute for VLBI in Europe (JIVE). The
software is designed to run on generic Linux-based computing clusters. The
correlation algorithm is explained in detail, as are some of the novel modes
that software correlation has enabled, such as wide-field VLBI imaging through
the use of multiple phase centres and pulsar gating and binning. This is
followed by an overview of the software architecture. Finally, the performance
of the correlator as a function of number of CPU cores, telescopes and spectral
channels is shown.Comment: Accepted by Experimental Astronom
Group Cognitive Behavioural Analysis System of Psychotherapy (CBASP) for persistently depressed outpatients:a retrospective chart review
BACKGROUND: Cognitive behavioural analysis system of psychotherapy (CBASP) is an effective individual treatment for persistent depressive disorder (PDD), but evidence on group treatment (Group-CBASP) is limited. Our aim was to review the effect of Group-CBASP on self-report depression severity in outpatients with PDD, overall and by age of depression-onset. METHODS: A retrospective chart review study (November 2011-March 2017) in 54 patients with PDD (29 late-onset, 25 early-onset). Patients were previously treated by pharmacotherapy (92.6%), psychotherapy (98.1%) and/or electroconvulsive therapy (11.1%). Group-CBASP involved 24 weekly sessions during 6 months, followed by individual appointments over 6 months. The Inventory of Depressive Symptoms -self rating(IDS-SR) was used at baseline and after 3, 6, 9 and 12 months, computing mean differences and response rates. RESULTS: The mean IDS-SR score decreased significantly from 39.83 at baseline to 33.78 at 6 months: a decrease from severe to moderate depression after 24 weeks of Group-CBASP, with a medium effect size (Cohen's d = .49). At 12 months, the mean IDS-SR score was 32.81, indicating moderate symptom levels remained. At 6 and 12 months, mean IDS-SR scores were similar among late- versus early-onset patients, but at 12 months response rates were higher among late-onset patients. LIMITATIONS: Although results of our study provide valuable input for future prospective studies, limitations were the use of a retrospective design and the small group size. CONCLUSION: Group-CBASP offered to an outpatient population with PDD was associated with clinically relevant decrease in self-reported symptom severity, and with sustained response particularly in patients with late onset of depression. PRACTITIONER POINTS: Group-CBASP seems to be a good alternative for CBASP in individual setting. Patients with late age of depression-onset seem to benefit more from Group-CBASP. This study shows that clinical relevant effects of Group-CBASP, followed by individual contacts, remain at least for 6 months. Research on personalizing treatment strategies is needed to improve patient assignment for Group-CBASP
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