Dynamic Interaction of an Uplifted Beam with the Supporting Soil

During seismic events, the overturning moment exerted by the hydrodynamic pressure of a liquid contained in an unanchored, thin-walled liquid storage tank tends to lift the tank base plate off its foundation. The nonlinear uplift and contact mechanism between the base plate and the underlying foundation is investigated in the present study. Nonlinearities due to base plate contact with foundation, large deflection and plastic hinge formation are examined

THE EFFECT OF PLANT GROWTH REGULATORS ON SHOOT FORMATION FROM CORM EXPLANT OF HEDYCHIUM CORONARIUM

This study was conducted for a micropropagation of Hedychium coronarium,an important medicinal herb, through sprouted rhizome buds. Rhizome buds were cultured on two different media; Murashige and Skoog medium (MS) and Gamborg medium (B5) without any growth regulators during the establishment stage. B5 medium gave a higher percentage of shoot formation 97.30% corresponding in shoot number and length comparing with MS medium. For shoot proliferation the micro shoots were placed on the B5 medium with two different cytokinins, kinitein (kin) and benzyl adenine (BA) at the concentrations of 0.0, 0.5, 1.0, 2.0 and 4.0 mg/l. Four mg/l of BA led to obtain high value of shoot production. For root formation, the produced shoots were placed on B5 medium plus different concentrations of two types of auxins IBA and IAA at the concentrations of 0.5, 1.0, 2.0 and 3.0 mg/l for each to study the best auxin and concentration which encouraged root formation (number and length). IBA proved a significantly efficient than IAA and encouraged root formation for both root number and root length. IBA at 3.0 mg/l gave the highest average of root number and length. All good rooted plants were cultured into pots containing vermiculite + peatmoss (1:1) in greenhouse, with 82% of survival percentage

Desarrollo y caracterización de una nueva formulación nano-lipoosómica de alendronato sódico con un polímero biodegradable

This work was supported by the pharmacological departmental grant.Background: Alendronate Sodium (ALDS) is the drug of choice for treatment of osteoporosis. However, 50% of the osteoporotic patients ceased the treatment within the first year due to its potential side effect on the gastrointestinal tract (GIT). Objective: The current study aimed to utilize nanotechnology to develop a nano-oral liposomal preparation containing biodegradable polymer (Starch) that enhance the drug prosperities. Methods: Nanoliposomes of ALDS were prepared using different concentrations of solubilized starch (0.1 - 0.5 g ) by thin film hydration method. A new method of alendronate quantitative determination was used to overcome the obstacle of its determination by using a new highly sensitive derivatization method. The selected formula was visualized using TEM, in vitro release studies and Stability study was also carried out. Furthermore, ulcerogenicity studies were performed to compare between the optimum prepared formula and a standard nonliposomal ALDS. Results: Six nano-oral liposomal formulations were prepared with zeta potentials ranging from -12 mV to -39 mV and a particle size ranging from 94 nm to 298 nm. The encapsulation efficiency studies demonstrated that the amount of ALDS entrapped within liposomes increased with increasing starch concentration. The stability studies confirmed the role of starch in increasing the stability of the prepared liposomes. In vitro release studies have demonstrated a relative delay in ALDS releases from the liposome core. Ulcerogenicity studies proofed that the prepared formula has a significant gastric tolerance. Conclusion: a novel liposomal formula of ALDS was developed with better tolerability. However, further clinical investigations are necessary to evaluate its therapeutic effectiveness.Antecedentes: El alendronato sódico (ALDS) es el fármaco de elección para el tratamiento de la osteoporosis. Sin embargo, el 50% de los pacientes osteoporóticos cesaron el tratamiento en el primer año debido a su posible efecto secundario en el tracto gastrointestinal (GIT). Objetivo: El presente estudio tiene como objetivo utilizar la nanotecnología para desarrollar una preparación liposomal nano-oral que contiene polímero biodegradable (almidón) que mejoran la prosperidad de la droga. Métodos: Se prepararon nanoliposomas de ALDS utilizando diferentes concentraciones de almidón solubilizado (0,1 - 0,5 g) mediante un método de hidratación de película delgada. Se utilizó un nuevo método de determinación cuantitativa de alendronato para superar el obstáculo de su determinación utilizando un nuevo método de derivatización altamente sensible. La fórmula seleccionada se visualizó utilizando TEM, estudios de liberación in vitro y se realizó también un estudio de estabilidad. Además, los estudios de ulcerogenicidad se realizaron para comparar entre la fórmula óptima preparada y un estándar no liposomal ALDS. Resultados : Se prepararon seis formulaciones liposomales nano-orales con potenciales zeta que oscilaban entre -12 mV y -39 mV y un tamaño de partícula que variaba de 94 nm a 298 nm. Los estudios de eficacia de la encapsulación demostraron que la cantidad de ALDS atrapada dentro de los liposomas aumentaba con el aumento de la concentración de almidón. Los estudios de estabilidad confirmaron el papel del almidón en el aumento de la estabilidad de los liposomas preparados. Los estudios de liberación in vitro han demostrado un retraso relativo en las liberaciones de ALDS del núcleo de liposomas. Los estudios de ulcerogenicidad demostraron que la fórmula preparada tiene una tolerancia gástrica significativa. Conclusión: se desarrolló una nueva fórmula liposomal de ALDS con mejor tolerabilidad. Sin embargo, otras investigaciones clínicas son necesarias para evaluar su efectividad terapéutica

Carcass measurements of naked neck and normal chicks

International audienc

Environmental sensitivity to mosquito transmitted diseases in El-Fayoum using spatial analyses

El-Fayoum governorate has unique characteristics which induces mosquito proliferation and thus increased the risk arisen from diseases transmission. Present study explores the role of remote sensing and GIS modeling integrated with field survey for mapping mosquito breeding sites and the areas under risk of diseases transmission in El-Fayoum governorate. Entomological surveys were conducted for a total number of 40 accessible breeding sites during the period 12-16 November 2017. A calibrated Landsat OLI image, synchronized with the field trip, was processed to produce Normalized Difference Vegetation Index (NDVI), Normalized Difference Moisture Index (NDMI), and Land Surface Temperature (LST). A cartographic GIS model was generated to predict breeding sites in the whole governorate and to assess the potential risk. The main filarial disease vector (Culex pipiens) was abundant at Atsa district, while Malaria vectors (Anopheles sergentii and Anopheles multicolor) were mainly distributed in El-Fayoum and Youssef El-Seddiq districts. Means levels of NDVI, NDMI and LST at breeding habitats were recorded; 0.18, 0.08 and 21.75° C, respectively. Results of the model showed that the highest predicted risk area was reported at Atsa district (94.4 km2) and Yousef El-Sediq (81.8 km2) while the lowest prediction was observed at Abshawai district (35.9 km2). It can be concluded that Atsa, Yousef El-Sedik and El-Fayoum districts are more vulnerable to Malaria and Filaria diseases outbreaks, thus precaution and pest control methods must be applied to mitigate the possible risks

Two spectrophotometric methods for simultaneous determination of some antihyperlipidemic drugs

Two simple, accurate, precise and economic spectrophotometric methods have been developed for simultaneous determination of Atorvastatin calcium (ATR) and Ezetimibe (EZ) in their bulk powder and pharmaceutical dosage form. Method (I) is based on dual wavelength analysis while method (II) is the mean centering of ratio spectra spectrophotometric (MCR) method. In method (I), two wavelengths were selected for each drug in such a way that the difference in absorbance was zero for the second drug. At wavelengths 226.6 and 244 nm EZ had equal absorbance values; therefore, these two wavelengths have been used to determine ATR; on a similar basis 228.6 and 262.8 nm were selected to determine EZ in their binary mixtures. In method II, the absorption spectra of both ATR and EZ with different concentrations were recorded over the range 200â350, divided by the spectrum of suitable divisor of both ATR and EZ and then the obtained ratio spectra were mean centered. The concentrations of active components were then determined from the calibration graphs obtained by measuring the amplitudes at 215â260 nm (peak to peak) for both ATR and EZ. Accuracy and precision of the developed methods have been tested; in addition recovery studies have been carried out in order to confirm their accuracy. On the other hand, selectivities of the methods were tested by application for determination of different synthetic mixtures containing different ratios of the studied drugs. The developed methods have been successfully used for determination of ATR and EZ in their combined dosage form and statistical comparison of the developed methods with the reported spectrophotometric one using F and Student's t-tests showed no significant difference regarding both accuracy and precision. Keywords: Atorvastatin, Ezetimibe, Dual wavelength method, Mean centering of ratio spectra, Spectrophotometr