45,312 research outputs found
Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step
Crystallization-based separation of curcumin from ternary mixtures of curcuminoids having compositions comparable to commercial extracts was studied experimentally. Based on solubility and supersolubility data of both, pure curcumin and curcumin in presence of the two major impurities demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC), seeded cooling crystallization procedures were derived using acetone, acetonitrile and 50/50 (wt/wt) mixtures of acetone/2-propanol and acetone/acetonitrile as solvents. Starting from initial curcumin contents of 67–75% in the curcuminoid mixtures single step crystallization processes provided crystalline curcumin free of BDMC at residual DMC contents of 0.6–9.9%. Curcumin at highest purity of 99.4% was obtained from a 50/50 (wt/wt) acetone/2-propanol solution in a single crystallization step. It is demonstrated that the total product yield can be significantly enhanced via addition of water, 2-propanol and acetonitrile as anti-solvents at the end of a cooling crystallization process
Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes.
ObjectiveTo compare different blood pressure (BP) levels in their association with the risk of renal outcomes in type 1 diabetes and to determine whether an intensive glycemic control strategy modifies this association.Research design and methodsWe included 1,441 participants with type 1 diabetes between the ages of 13 and 39 years who had previously been randomized to receive intensive versus conventional glycemic control in the Diabetes Control and Complications Trial (DCCT). The exposures of interest were time-updated systolic BP (SBP) and diastolic BP (DBP) categories. Outcomes included macroalbuminuria (>300 mg/24 h) or stage III chronic kidney disease (CKD) (sustained estimated glomerular filtration rate <60 mL/min/1.73 m2).ResultsDuring a median follow-up time of 24 years, there were 84 cases of stage III CKD and 169 cases of macroalbuminuria. In adjusted models, SBP in the <120 mmHg range was associated with a 0.59 times higher risk of macroalbuminuria (95% CI 0.37-0.95) and a 0.32 times higher risk of stage III CKD (95% CI 0.14-0.75) compared with SBPs between 130 and 140 mmHg. DBP in the <70 mmHg range were associated with a 0.73 times higher risk of macroalbuminuria (95% CI 0.44-1.18) and a 0.47 times higher risk of stage III CKD (95% CI 0.21-1.05) compared with DBPs between 80 and 90 mmHg. No interaction was noted between BP and prior DCCT-assigned glycemic control strategy (all P > 0.05).ConclusionsA lower BP (<120/70 mmHg) was associated with a substantially lower risk of adverse renal outcomes, regardless of the prior assigned glycemic control strategy. Interventional trials may be useful to help determine whether the currently recommended BP target of 140/90 mmHg may be too high for optimal renal protection in type 1 diabetes
Reconstruction from Radon projections and orthogonal expansion on a ball
The relation between Radon transform and orthogonal expansions of a function
on the unit ball in \RR^d is exploited. A compact formula for the partial
sums of the expansion is given in terms of the Radon transform, which leads to
algorithms for image reconstruction from Radon data. The relation between
orthogonal expansion and the singular value decomposition of the Radon
transform is also exploited.Comment: 15 page
Spin Dependence of Interfacial Reflection Phase Shift at Cu/Co Interface
The spin dependent reflection at the interface is the key element to
understand the spin transport. By completely solving the scattering problem
based on first principles method, we obtained the spin resolved reflectivity
spectra. The comparison of our theoretical results with experiment is good in a
large energy scale from Fermi level to energy above vacuum level. It is found
that interfacial distortion is crucial for understanding the spin dependence of
the phase gain at the CuCo interface. Near the Fermi level, image state
plays an important role to the phase accumulation in the copper film.Comment: 6 papges, 3 figures, accepted by Physical Review
High speed single photon detection in the near-infrared
InGaAs avalanche photodiodes (APDs) are convenient for single photon
detection in the near-infrared (NIR) including the fibre communication bands
(1.31/1.55 m). However, to suppress afterpulse noise due to trapped
avalanche charge, they must be gated with MHz repetition frequencies, thereby
severely limiting the count rate in NIR applications. Here we show gating
frequencies for InGaAs-APDs well beyond 1 GHz. Using a self-differencing
technique to sense much weaker avalanches, we reduce drastically afterpulse
noise. At 1.25 GHz, we obtain a detection efficiency of 10.8% with an
afterpulse probability of 6.16%. In addition, the detector features low jitter
(55 ps) and a count rate of 100 MHz
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