Improvements in BepiColombo and JUICE radio science experiments with a multi-station tracking configuration for the reduction of Doppler noise

Radio science experiments for planetary geodesy mostly rely on measurements of the Doppler shift of microwave signals sent to a spacecraft by an Earth station, and retransmitted back coherently in phase to the same antenna (two-way link). The retransmitted signal can also be received by a different station in a listen-only configuration (three-way link). In state-of-the-art tracking systems, such as the ones will be used on the future ESA's missions JUICE and BepiColombo, the Doppler error budget is dominated by local noise sources arising at the ground-station, in particular tropospheric scintillation and unmodeled motions of the antenna's structure. In this work, a novel technique aimed at reducing these disturbances is analyzed, with particular emphasis on its benefits to BepiColombo's and JUICE's radio science experiments. The method, referred to as Time-Delay Mechanical-noise Cancellation (TDMC), relies on simultaneous two-way and three-way spacecraft tracking, the latter employing a stiffer listen-only antenna with better mechanical stability and located in a favorable dry region more immune to tropospheric noise. In fact, a proper linear combination of time-shifted observables from the two-way and three-way links can replace local noises of the two-way ground-station with those coming from the listen-only antenna, translating into increased accuracy of the final measurements, while preserving the original Doppler content. We show the results of covariance analyses performed with a multi-arc weighted least square estimator for the entire BepiColombo's Hermean phase and JUICE's flybys of Callisto. We compare the two solutions obtained with and without the application of the TDMC technique. For BepiColombo and JUICE radio science experiments, the two-way links are baselined from the 35-m DSA-3 (Malargüe, Argentina) and the 34-m DSS 25 (Goldstone, California). For the three-way link, we select the 12-m Large Latin American Millimeter Array (LLAMA) antenna for three reasons: 1) its mechanical rigidity with respect to large beam-waveguide antennas, 2) its unique position in the extremely dry Puna de Atacama desert, that assures low tropospheric noise, and 3) its limited longitudinal separation from the two other ground-stations, granting sufficient common visibility time to perform the requested combination of the observables. Besides its noise-reduction effect, enabling unprecedented levels of accuracy on Doppler measurements, TDMC provides also a back-up for unique events: a crucial satellite flyby or a specific passage over a site of particular geophysical interest. Indeed, measurements become virtually independent of unfavorable meteorological conditions at the transmitting station

Analysis of Cassini radio tracking data for the construction of INPOP19a: a new estimate of the Kuiper belt mass

Context. Recent discoveries of new trans-Neptunian objects have greatly increased the attention by the scientific community to this relatively unknown region of the solar system. The current level of precision achieved in the description of planet orbits has transformed modern ephemerides in the most updated tools for studying the gravitational interactions between solar system bodies. In this context, the orbit of Saturn plays a primary role, especially thanks to Cassini tracking data collected during its 13-year mission around the ringed planet. Planetary ephemerides are currently mainly built using radio data, in particular with normal points derived from range and Doppler observables exchanged between ground stations and interplanetary probes. Aims. We present an analysis of Cassini navigation data aimed at producing new normal points based on the most updated knowledge of the Saturnian system developed throughout the whole mission. We provide additional points from radio science dedicated passes of Grand Finale orbits and Titan flybys. An updated version of the INPOP planetary ephemerides based upon these normal points is presented, along with a new estimate of the mass of trans-Neptunian object rings located in the 2:1 and 3:2 mean motion resonances with Neptune. Methods. We describe in detail the orbit determination process performed to construct the normal points and their associated uncertainties and how we process those points to produce a new planetary ephemeris. Results. From the analysis, we obtained 623 new normal points for Saturn with metre-level accuracy. The ephemeris INPOP19a, including this new dataset, provides an estimated mass for the trans-Neptunian object rings of (0.061  ±  0.001)M⊕

Induced pluripotent stem cells in hematology: current and future applications

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation

New constraints on the location of P9 obtained with the INPOP19a planetary ephemeris

Context. We used the new released INPOP19a planetary ephemerides benefiting from Jupiter-updated positions by the Juno mission and reanalyzed Cassini observations. Aims. We test possible locations of the unknown planet P9. To do this, we used the perturbations it produces on the orbits of the outer planets, more specifically, on the orbit of Saturn. Methods. Two statistical criteria were used to identify possible acceptable locations of P9 according to (i) the difference in planetary positions when P9 is included compared with the propagated covariance matrix, and (ii) the χ2 likelihood of postfit residuals for ephemerides when P9 is included. Results. No significant improvement of the residuals was found for any of the simulated locations, but we provide zones that induce a significant degradation of the ephemerides. Conclusions. Based on the INPOP19a planetary ephemerides, we demonstrate that if P9 exists, it cannot be closer than 500 AU with a 5 M⊕ and no closer than 650 AU with a 10 M⊕ . We also show that there is no clear zone that would indicate the positive existence of planet P9, but there are zones for which the existence of P9 is compatible with the 3σ accuracy of the INPOP planetary ephemerides

Evolution of INPOP planetary ephemerides and Bepi-Colombo simulations

We give here a detailed description of the latest INPOP planetary ephemerides INPOP20a. We test the sensitivity of the Sun oblateness determination obtained with INPOP to different models for the Sun core rotation. We also present new evaluations of possible GRT violations with the PPN parameters $\beta$,$\gamma$ and $\dot{\mu}/\mu$. With a new method for selecting acceptable alternative ephemerides we provide conservative limits of about $7.16 \times 10^{-5}$ and $7.49 \times 10^{-5}$ for $\beta-1$ and $\gamma-1$ respectively using the present day planetary data samples. We also present simulations of Bepi-Colombo range tracking data and their impact on planetary ephemeris construction. We show that the use of future BC range observations should improve these estimates, in particular $\gamma$. Finally, interesting perspectives for the detection of the Sun core rotation seem to be reachable thanks to the BC mission and its accurate range measurements in the GRT frame.Comment: Proceedings of the IAU Symposium 364 "Multi-scale dynamics of space objects

Detecting Java software similarities by using different clustering techniques

Background: Research on empirical software engineering has increasingly been conducted by analysing and measuring vast amounts of software systems. Hundreds, thousands and even millions of systems have been (and are) considered by researchers, and often within the same study, in order to test theories, demonstrate approaches or run prediction models. A much less investigated aspect is whether the collected metrics might be context-specific, or whether systems should be better analysed in clusters. Objective: The objectives of this study are (i) to define a set of clustering techniques that might be used to group similar software systems, and (ii) to evaluate whether a suite of well-known object-oriented metrics is context-specific, and its values differ along the defined clusters. Method: We group software systems based on three different clustering techniques, and we collect the values of the metrics suite in each cluster. We then test whether clusters are statistically different between each other, using the Kolgomorov-Smirnov (KS) hypothesis testing. Results: Our results show that, for two of the used techniques, the KS null hypothesis (e.g., the clusters come from the same population) is rejected for most of the metrics chosen: the clusters that we extracted, based on application domains, show statistically different structural properties. Conclusions: The implications for researchers can be profound: metrics and their interpretation might be more sensitive to context than acknowledged so far, and application domains represent a promising filter to cluster similar systems

INPOP Planetary ephemerides and applications in the frame of the BepiColombo mission including new constraints on the graviton mass and dilaton parameters

We present here the new results obtained with the INPOP planetary ephemerides and BepiColombo radio-science simulations. We give new constraints for the classic General Relativity tests in terms of violation of the PPN parameters $\beta$ and $\gamma$ and the time variation of the gravitational constant G. We also present new limits for the mass of the graviton and finally we obtain new acceptable intervals for the dilaton parameters $\alpha_{0}$, $\alpha_{T}$ and $\alpha_{G}$. Besides these tests of gravitation, we also study the possibility of detecting the Sun core rotation.Comment: arXiv admin note: substantial text overlap with arXiv:2111.0449

A 2-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in Ferrara University Hospital, Italy

Background: Healthcare-Associated Infections (HAIs) represent one of the leading issues to patient safety as well as a significant economic burden. Similarly, Antimicrobial Use (AMU) and Resistance (AMR) represent a growing threat to global public health and the sustainability of healthcare services. Methods: A Point Prevalence Survey (PPS) following the 2016 ECDC protocol for HAI prevalence and AMU was conducted at Ferrara University Hospital (FUH). Data were collected by a team of trained independent surveyors in 2016 and 2018. Risk factors independently associated with HAI were assessed by a multivariate logistic regression model. Results: Of the 1102 patients surveyed, 115 (10.4%) had an active HAI and 487 (44.2%) were on at least 1 systemic antimicrobial agent. Factors independently associated with increased HAI risk were a "Rapidly Fatal" McCabe score (expected fatal outcome within 1 year), presence of medical devices (PVC, CVC, indwelling urinary catheter or mechanically assisted ventilation) and a length of hospital stay of at least 1 week. The most frequent types of HAI were pneumonia, bloodstream infections, and urinary tract infections. Antimicrobial resistance to third-generation cephalosporins was observed in about 60% of Enterobacteriaceae. Conclusions: The survey reports a high prevalence of HAI and AMU in FUH. Repeated PPSs are useful to control HAIs and AMU in large acute-care hospitals, highlighting the main problematic factors and allowing planning for improvement actions

OSSMETER: Automated measurement and analysis of open source software

International audienceDeciding whether an open source software (OSS) meets the requiredstandards for adoption in terms of quality, maturity, activity of development anduser support is not a straightforward process. It involves analysing various sourcesof information, including the project’s source code repositories, communicationchannels, and bug tracking systems. OSSMETER extends state-of-the-art techniquesin the field of automated analysis and measurement of open-source software(OSS), and develops a platform that supports decision makers in the processof discovering, comparing, assessing and monitoring the health, quality, impactand activity of opensource software. To achieve this, OSSMETER computestrustworthy quality indicators by performing advanced analysis and integrationof information from diverse sources including the project metadata, source coderepositories, communication channels and bug tracking systems of OSS projects