Parton Distributions in Impact Parameter Space

Fourier transform of the generalized parton distributions (GPDs) at zero skewness with respect to the transverse momentum transfer gives the distribution of partons in the impact parameter space. We investigate the GPDs as well as the impact parameter dependent parton distributions (ipdpdfs) by expressing them in terms of overlaps of light front wave functions (LFWFs) and present a comparative study using three different model LFWFs.Comment: 13 pages, 6 figure

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2.

MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated. We employed multimodal strategy based on in-house PCa clinical samples, publicly available TCGA cohorts, a panel of cell lines, in silico analyses, and a series of in vitro and in vivo assays to investigate the role of miR-466 in PCa. Expression analyses revealed that miR-466 is under-expressed in PCa compared to normal tissues. Reconstitution of miR-466 in metastatic PCa cell lines impaired their oncogenic functions such as cell proliferation, migration/invasion and induced cell cycle arrest, and apoptosis compared to control miRNA. Conversely, attenuation of miR-466 in normal prostate cells induced tumorigenic characteristics. miR-466 suppressed PCa growth and metastasis through direct targeting of bone-related transcription factor RUNX2. Overexpression of miR-466 caused a marked downregulation of integrated network of RUNX2 target genes such as osteopontin, osteocalcin, ANGPTs, MMP11 including Fyn, pAkt, FAK and vimentin that are known to be involved in migration, invasion, angiogenesis, EMT and metastasis. Xenograft models indicate that miR-466 inhibits primary orthotopic tumor growth and spontaneous metastasis to bone. Receiver operating curve and Kaplan-Meier analyses show that miR-466 expression can discriminate between malignant and normal prostate tissues; and can predict biochemical relapse. In conclusion, our data strongly suggests miR-466-mediated attenuation of RUNX2 as a novel therapeutic approach to regulate PCa growth, particularly metastasis to bone. This study is the first report documenting the anti-bone metastatic role and clinical significance of miR-466 in prostate cancer

Magnetic moments of the low-lying JP= 1/2−J^P=\,1/2^-, 3/2−3/2^- Λ\Lambda resonances within the framework of the chiral quark model

The magnetic moments of the low-lying spin-parity $J^P=$ $1/2^-$, $3/2^-$ $\Lambda$ resonances, like, for example, $\Lambda(1405)$ $1/2^-$, $\Lambda(1520)$ $3/2^-$, as well as their transition magnetic moments, are calculated using the chiral quark model. The results found are compared with those obtained from the nonrelativistic quark model and those of unitary chiral theories, where some of these states are generated through the dynamics of two hadron coupled channels and their unitarization

Oscillation of a neutral difference equation

AbstractThis paper is concerned with the oscillation of the bounded solutions of neutral difference equation where Δ is the forward difference operator defined by Δn = n+1 - n

Neoadjuvant ifosfamide and epirubicin in the treatment of malignant peripheral nerve sheath tumors

Background and Objectives. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with poor overall survival. Response to chemotherapy has been debated for these tumors. Methods. We performed a retrospective analysis of the patients at our institution with a biopsy-proven diagnosis of MPNST that underwent neoadjuvant chemotherapy prior to surgery. Results. We retrospectively identified five patients who received neoadjuvant chemotherapy with epirubicin and ifosfamide that demonstrated a 30% reduction in tumor growth and a 60% response rate by RECIST criteria. Additionally, a metabolic response was observed in all three patients who received serial PET scans during neoadjuvant treatment. The clinical benefit rate, which includes stable disease, was 100%. Conclusions. Our data suggest that MPNSTs do respond to epirubicin and ifosfamide based chemotherapy and prospective studies are warranted to further define the clinical benefit

Chiral constituent quark model and the coupling strength of eta'

Using the latest data pertaining to \bar u-\bar d asymmetry and the spin polarization functions, detailed implications of the possible values of the coupling strength of the singlet Goldstone boson \eta' have been investigated in the \chiCQM with configuration mixing. Using \Delta u, \Delta_3, \bar u-\bar d and \bar u/\bar d, the possible ranges of the coupling parameters a, \alpha^ 2, \beta^ 2 and \zeta^ 2, representing respectively the probabilities of fluctuations to pions, K, \eta and \eta^{'}, are shown to be 0.10 \lesssim a \lesssim 0.14, 0.2\lesssim \alpha \lesssim 0.5, 0.2\lesssim \beta \lesssim 0.7 and 0.10 lesssim |\zeta| \lesssim 0.70. To constrain the coupling strength of \eta', detailed fits have been obtained for spin polarization functions, quark distribution functions and baryon octet magnetic moments corresponding to the following sets of parameters: a=0.1, \alpha=0.4, \beta=0.7, |\zeta|=0.65 (Case I); a=0.1, \alpha=0.4, \beta=0.6, |\zeta|=0.70 (Case II); a=0.14, \alpha=0.4, \beta=0.2, \zeta=0 (Case III) and a=0.13, \alpha=\beta=0.45, |\zeta|=0.10 (Case IV). Case I represents the calculations where a is fixed to be 0.1, in accordance with earlier calculations, whereas other parameters are treated free and the Case IV represents our best fit. The fits clearly establish that a small non-zero value of the coupling of \eta' is preferred over the higher values of \eta' as well as when \zeta=0, the latter implying the absence of \eta' from the dynamics of \chiCQM. Our best fit achieves an overall excellent fit to the data, in particular the fit for \Delta u, \Delta d, \Delta_8 as well as the magnetic moments \mu_{n}, \mu_{\Sigma^-}, \mu_{\Sigma^+} and \mu_{\Xi^-} is almost perfect, the \mu_{\Xi^-} being a difficult case for most of the similar calculations.Comment: 8 RevTeX pages, 2 Tables, Revised version to appear in Int.J.Mod.Phys

Genomic profiling of circulating tumor DNA from cerebrospinal fluid to guide clinical decision making for patients with primary and metastatic brain tumors

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS

Strangeness and Chiral Symmetry Breaking

The implications of chiral symmetry breaking and SU(3) symmetry breaking have been studied in the chiral constituent quark model ($\chi$CQM). The role of hidden strangeness component has been investigated for the scalar matrix elements of the nucleon with an emphasis on the meson-nucleon sigma terms. The $\chi$CQM is able to give a qualitative and quantitative description of the "quark sea" generation through chiral symmetry breaking. The significant contribution of the strangeness is consistent with the recent available experimental observations.Comment: 10 pages, 1 table. To appear in Mod. Phys. Lett.