School Dropout by Gender in the European Union: Evidence from Spain

The aim of this paper is double, to describe the scope of high school dropout in Spain in comparative terms with Europe and to provide empirical evidence about its main determinants from a gender perspective. Using data from the Eurostat LFS for 1996-2009, the study makes evident a singularity for Spain: the important gender disparity at school. The multivariate statistical analysis shows that for females the academic performance, father’s nationality and mother’s educational level are the most determining factors in their education demand decisions. For males, father’s occupation and labour market conditions are the most significant influences

School Dropout by Gender in the European Union: Evidence from Spain

The aim of this paper is double, to describe the scope of high school dropout in Spain in comparative terms with Europe and to provide empirical evidence about its main determinants from a gender perspective. Using data from the Eurostat LFS for 1996-2009, the study makes evident a singularity for Spain: the important gender disparity at school. The multivariate statistical analysis shows that for females the academic performance, father’s nationality and mother’s educational level are the most determining factors in their education demand decisions. For males, father’s occupation and labour market conditions are the most significant influences

DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis

Growing evidence shows that autophagy is deficient in neurodegenerative and psychiatric diseases, and that its induction may have beneficial effects in these conditions. However, as autophagy shares signaling pathways with cell death and interferes with protein synthesis, prolonged use of autophagy inducers available nowadays is considered unwise. The search for novel autophagy inducers indicates that DRD2 (dopamine receptor 2)-DRD3 ligands may also activate autophagy, though critical aspects of the action mechanisms and effects of dopamine ligands on autophagy are still unknown. In order to shed light on this issue, DRD2- and DRD3-overexpressing cells and drd2 KO, drd3 KO and wild-type mice were treated with the DRD2-DRD3 agonist pramipexole. The results revealed that pramipexole induces autophagy through MTOR inhibition and a DRD3-dependent but DRD2-independent mechanism. DRD3 activated AMPK followed by inhibitory phosphorylation of RPTOR, MTORC1 and RPS6KB1 inhibition and ULK1 activation. Interestingly, despite RPS6KB1 inhibition, the activity of RPS6 was maintained through activation of the MAPK1/3-RPS6KA pathway, and the activity of MTORC1 kinase target EIF4EBP1 along with protein synthesis and cell viability, were also preserved. This pattern of autophagy through MTORC1 inhibition without suppression of protein synthesis, contrasts with that of direct allosteric and catalytic MTOR inhibitors and opens up new opportunities for G protein-coupled receptor ligands as autophagy inducers in the treatment of neurodegenerative and psychiatric diseases. Abbreviations: AKT/Protein kinase B: thymoma viral proto-oncogene 1; AMPK: AMP-activated protein kinase; BECN1: beclin 1; EGFP: enhanced green fluorescent protein; EIF4EBP1/4E-BP1: eukaryotic translation initiation factor 4E binding protein 1; GPCR; G protein-coupled receptor; GFP: green fluorescent protein; HEK: human embryonic kidney; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2K/MEK: mitogen-activated protein kinase kinase; MAPK1/ERK2: mitogen-activated protein kinase 1; MAPK3/ERK1: mitogen-activated protein kinase 3; MDA: malonildialdehyde; MTOR: mechanistic target of rapamycin kinase; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PPX: pramipexole; RPTOR/raptor: regulatory associated protein of MTOR, complex 1; RPS6: ribosomal protein S6; RPS6KA/p90S6K: ribosomal protein S6 kinase A; RPS6KB1/p70S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type.This work was supported by the Spanish Ministerio de Economía y Competitividad [BFU2016-77363-R] and Gobierno Autónomo de Canarias [2018-00000034] to T.G.H. D.L.R. was supported by the “Programa Agustín de Betancourt” (Cabildo Insular de Tenerife). F.F.R. and A.F.C. were supported by the Programme Ayudas para contratos predoctorales para la formación de doctores”, Spanish Ministerio de Economía y Competitividad [BES-2014-067781 and BES-2017‐079923, respectively]; Consejería de Educación, Universidades y Sostenibilidad, Gobierno de Canarias [2018-00000034]; Ministerio de Economía, Industria y Competitividad, Gobierno de España [BFU2016-77363-R]; Ministerio de Economía, Industria y Competitividad, Gobierno de España [BES-2014-067781]; Ministerio de Economía, Industria y Competitividad, Gobierno de España [BES-2017‐079923]; Cabildo de Tenerife (ES) [Programa Agustín de Betancourt]

Postharvest biology and technology of plum

Games can provide an effective and replicable space in which stakeholders learn skills necessary for deliberative and pluralist policymaking. These skills are especially important for “nexus” policy issues that are typically characterised by multiple, competing problem frames involving overlapping networks of stakeholders. In this position paper, we describe three serious games that serve as a space for players (stakeholders) and researchers to jointly explore alternative solutions to complex resource management issues: the Water-Food-Energy Nexus Game (Nexus Game); the Narubu Game of Many Voices (Narubu Game); and the Forest Governance Game (Forest Game). The games contain instructive and reflexive mechanisms that prompt players to self-discover common challenges associated with complex nexus issues, including conflicting institutional mandates, social dilemmas, contending worldviews, and plural interpretations of science