Assessing the benefits of supply chain trust: NK simulation-based methodology and application

Previous literature has emphasized that developing trust among supply chain (SC) firms is a critical element in achieving SC effectiveness. Since developing trust is an expensive task, however, making an informed decision whether to invest or not in trust requires careful assessment of trust benefits. Therefore, we advance a simulation-based methodology to quantify performance improvements associated with trust in SCs. We develop an NK simulation model of a generic SC that captures the SC dynamics under two alternative scenarios, characterized by the presence and absence of trust respectively. A procedure is then illustrated to quantify the benefits of trust in the SC. We also apply our proposed methodology to a real-world SC. Results show that, when trust is pervasive across the SC, performance increases at both the levels of the overall SC and its leading firm

Socio-cultural sustainability of private healthcare providers in an Indian slum setting: A bottom-of-the-pyramid perspective

Delivery of affordable healthcare services to communities is a necessary precondition to poverty alleviation. Co-creation approaches to the development of business models in the healthcare industry proved particularly suitable for improving the health-seeking behavior of BOP patients. However, scant research was conducted to understand BOP consumers’ decision-making process leading to specific healthcare choices in slum settings, and the relative balance of socio-cultural and socio-economic factors underpinning patients’ preferences. This article adopts a mixed-method approach to investigate the determinants of BOP patients’ choice between private and public hospitals. Quantitative analysis of a database, composed of 436 patients from five hospitals in Ahmedabad, India, indicates that BOP patients visit a public hospital significantly more than top-of-the-pyramid (TOP) patients. However, no significant difference emerges between BOP and TOP patients for inpatient or outpatient treatments. Qualitative findings based on 21 interviews with BOP consumers from selected slum areas led to the development of a grounded theory model, which highlights the role of aspirational demand of BOP patients toward private healthcare providers. Overall, healthcare provider choice emerges as the outcome of a collective socio-cultural decision-making process, which often assigns preference for private healthcare services because of the higher perceived quality of private providers, while downplaying affordability concerns. Implications for healthcare providers, social entrepreneurs, and policy-makers are discussed

String Dilaton Fluid Cosmology

We investigate $(n+1)$-dimensional string-dilaton cosmology with effective dilaton potential in presence of perfect-fluid matter.We get exact solutions parametrized by the constant \gam of the state equation p=(\gam-1)\rho, the spatial dimension number $n$, the bulk of matter, and the spatial curvature constant $k$. Several interesting cosmological behaviours are selected. Finally we discuss the recovering of ordinary Einstein gravity starting from string dominated regime and a sort of asymptotic freedom due to string effective coupling.Comment: 16 pages, Latex, submitted to Int. Jou. Mod. Phys.

Cryosectioning Method for Microdissection of Murine Colonic Mucosa.

The colonic mucosal tissue provides a vital barrier to luminal antigens. This barrier is composed of a monolayer of simple columnar epithelial cells. The colonic epithelium is dynamically turned over and epithelial cells are generated in the stem cell containing crypts of Lieberkuhn. Progenitor cells produced in the crypt-bases migrate toward the luminal surface, undergoing a process of cellular differentiation before being shed into the gut lumen. In order to study these processes at the molecular level, we have developed a simple method for the microdissection of two spatially distinct regions of the colonic mucosa; the proliferative crypt zone, and the differentiated surface epithelial cells. Our objective is to isolate specific crypt and surface epithelial cell populations from mouse colonic mucosa for the isolation of RNA and protein

Molecular analysis has allowed the definitive diagnosis of multiple acyl-CoA dehydrogenase deficiency (MADD)

Multiple acyl-CoA dehydrogenation deficiency (MADD) is a rare autosomal recessive disorder due to defects in the electron transfer flavoprotein (ETF) or in the electron transfer flavoprotein dehydrogenase (ETFDH) enzymes, involved in the mitochondrial electron transport chain. Patients with MADD fall into different clinical phenotypes, ranging from a severe neonatal presentation, with metabolic acidosis, cardiomyopathy and liver disease to a mild childhood/adult disease, with episodic metabolic decompensation, muscle weakness and respiratory failure.Nowadays, the MADD diagnosis is established by the presence of dicarboxylic organic acids and acylglycine derivatives in the urine and increased levels of medium-and long-chain acylcarnitines in the blood. Mutations in ETFA, ETFB, ETFDH genes, encoding for alpha and beta subunits of ETF and for ETF-dehydrogenase are associated with MADD. We report the case of a three years old child, affected by lethargy and asthenia associated with anorexia. Biochemical analyses showed hypoketotic hypoglycemia with remarkable increments in transaminases, lactic dehydrogenase, aldolase and creatine kinase. The chromatographic layout of urinary organic acids showed a typical dicarboxylic aciduria. Thus, based on these features, MADD was suspected. Fifteen years later, at the age of 19, MADD diagnosis was confirmed by molecular analysis, showing a compound heterozygosity for the mutations c.1074G>C (p.R358S; HGMD: CM031670 in HGMD database) and c.1073G>A (p.R358K) in the ETFDH gene. The c.1073G>A (p.R358K; rs796051959) mutation is reported in ClinVar database as pathogenic allele, although lacking link to a specific clinical condition. However, familial segregation study and in silico analysis, performed by bioinformatics tools, confirmed that this substitution is likely pathogenetic. Her parents were healthy carriers of one of the two mutations. It is known that the severity of the clinical phenotype of MADD may be related to the type of mutation in the ETFA/ETFB/ETFDH genes. Particularly, missense mutations in the ETFDH gene, leaving a detectable residual enzyme activity, may account for the milder form of the disease, as is the case here. In conclusion we suggest that molecular analysis is essential to the definitive diagnosis of MADD and to direct the adequate therapeutic management. Thus, through a close nutritional follow up, a few months ago the patient gave birth to a healthy boy. References Olsen et al. Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency. Hum Mutat. 2003; 22:12–23

Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: A pilot study

Dietary polyphenols have beneficial effects on glucose/lipid metabolism in subjects at high risk to develop type 2 diabetes; however, the underlying mechanisms are not clear. We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters

Visitor-sensing: Involving the crowd in cultural heritage organizations

As organizations are increasingly involving individuals across their boundaries in the generation of new knowledge, crowd involvement can also be beneficial to cultural heritage organizations. We argue that in an "Open Innovation in Science" approach, visitors can contribute to generate new scientific knowledge concerning their behavior and preferences, by which museum managers can re-design the cultural offerings of their institutions in ways that generate major economic and social impacts. Accordingly, we advance visitor-sensing as a novel framework in which museum managers leverage digital technologies to collect visitors' ideas, preferences, and feedback in order to improve path design and the organization of artwork in exhibitions, and to shape a more satisfying museum experience for visitors. We contend that visitor-sensing has the potential to yield higher numbers of visitors, with positive impacts in terms of increased revenues and increased literacy of the general public, thus benefiting the economic and social sustainability of cultural organizations towards the achievement of the Sustainable Development Goals outlined in the Agenda 2030

Realizing the NPD Benefits of the Firm Innovation Strategy: The Role of Supply Management and Supply Chain Transformational Leadership

Firm innovation strategy (FIS) is crucial for new product development (NPD) performance. Few studies have revealed how theFIS that recognizes the importance of supply chain (SC) resources can improve NPD performance through SC management. Thisstudy emphasizes the mediating role of supply management, including innovativeness in supply management and firm-supplierrelationship. We argue that supply chain transformational leadership (SCTL) moderates the relationship between FIS and supplymanagement. Using data from 232 Chinese manufacturing firms and applying structural equation modeling and regressionanalysis, we tested the hypotheses. The results show that innovativeness in supply management and firm-supplier relationshipmediate the relationship between the FIS and NPD performance. SCTL positively moderates the influence of FIS on supply man-agement. These findings contributes to NPD outcomes. This study offers theoretical and empirical insights into SC management

CRASHES COMPARISON BEFORE AND AFTER SPEED CONTROL CAMERAS INSTALLATION: CASE STUDIES ON RURAL ROADS IN LITHUANIA AND ITALY

The study focused on the appraisal of the effectiveness of fixed speed control cameras regarding the reduction in crashes on the main study road in Lithuania. The task is to install the same technical reliable and validated solutions on homogeneous road sections in Italy that reflect the same geometric, traffic features as well as driver speed behaviour than those observed in Lithuania. The case studies were Via Baltica in Lithuania and S.P.430 in the Southern Italy. Three main roads belong to Via Baltica (A5, A8, A10) where a total of 191 crashes occurred during five years (2009−2013) of study with 276 injuries and 69 deaths. A total of five fixed speed cameras were placed on A5 road, two on A8 road and four on A10 road. After the installation of the speed control cameras, it was observed in two years a reduction in the number of crashes with deaths (51%) and injuries (27%) as well as a decrease in the crash rate values (19%). The case study in Italy was S.P.430 that consists of fourteen homogeneous road sections on basis of the curvature change rate evaluation and administrative government. A total of 138 crashes with 246 injuries and 20 deaths were recorded in 2009−2013 on a total length of 73 km almost. According to Italian methodology based on the calculation of crash rates for homogeneous road sections, the crash levels have been associated with each study road section. It was observed that 79% of the sections are characterized by a low crash level and the remaining 21% by a severe crash level. S.P.430 road sections with a severe crash level are potential locations with speed control cameras. As speed control cameras are missing in S.P. 430, there si no a remarkable reduction in the number of the crashes during the years as happened in Lithuania by similar infrastructural, land context, driver speed behaviour features between two cases study