21 research outputs found
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men
Aim: To compare the effects of cold exposure and the β3-adrenergic receptor agonist
mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT)
activity in South Asians versus Europids.
Materials and Methods: Ten lean Dutch South Asian (aged 18-30 years; body mass
index [BMI] 18-25 kg/m2
) and 10 age- and BMI-matched Europid men participated in
a randomized, double-blinded, cross-over study consisting of three interventions:
short-term (~ 2 hours) cold exposure, mirabegron (200 mg one dose p.o.) and placebo. Before and after each intervention, we performed lipidomic analysis in serum,
assessed resting energy expenditure (REE) and skin temperature, and measured BAT
fat fraction by magnetic resonance imaging.
Results: In both ethnicities, cold exposure increased the levels of several serum lipid
species, whereas mirabegron only increased free fatty acids. Cold exposure increased
lipid oxidation in both ethnicities, while mirabegron increased lipid oxidation in
Europids only. Cold exposure and mirabegron enhanced supraclavicular skin temperature in both ethnicities. Cold exposure decreased BAT fat fraction in both
ethnicities. After the combination of data from both ethnicities, mirabegron
decreased BAT fat fraction compared with placebo.
Conclusions: In South Asians and Europids, cold exposure and mirabegron induced
beneficial metabolic effects. When combining both ethnicities, cold exposure and
mirabegron increased REE and lipid oxidation, coinciding with a higher supraclavicular
skin temperature and lower BAT fat fraction.Diabetes Research Foundation Fellowship
2015.81.1808Netherlands CardioVascular Research Initiative: 'the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences'
CVON2014-02 ENERGISE
CVON2017-20 GENIUS-IIEuropean Union (EU)
602485European Research Council (NOMA-MRI) PCNR is an Established Investigator of the Netherlands Heart Foundation
2009T03
Riparian and adler forests as the foundation of rare and endangered macromycetes
W artykule scharakteryzowano 11 wybranych gatunków macromycetes rzadkich i zagrożonych w Polsce, zanotowanych podczas badań mikocenologicznych przeprowadzonych na terenie Pojezierza Krajeńskiego. Podano uwagi dotyczące ekologii, rozmieszczenia, stopnia rzadkości i zagrożenia w Polsce następujących gatunków: Acrospermum compressum Tode: Fr., Bisporella confluens (Sacc.) Korf & Bujakiewicz, Camarops polysperma (Mont.) J. H. Miller, Cordyceps bifusispora O. E. Erikss., Entoloma dysthaloides Noordel., Entoloma jahnii Wölfel & Winterh., Inocybe calospora Quél., Mycena pterigena (Fr.) Kummer, Rimbachia arachnoidea (Peck) Redhead, Russula alnetorum Romagn. i Tremella hypogymniae Diederich & M. S. Christ.In the article there are characterized chosen 11 species of macromycetes that are rare and endangered in Poland and were catalogued during the mikocenologic research held on Pojezierze Krajeńskie. The observations were made regarding ecology, situating and level of being rare and endangered in Poland of the following species: Acrospermum compressum Tode: Fr., Bisporella confluens (Sacc.) Korf & Bujakiewicz, Camarops polysperma (Mont.) J. H. Miller, Cordyceps bifusispora O. E. Erikss., Entoloma dysthaloides Noordel., Entoloma jahnii Wölfel & Winterh., Inocybe calospora Quél., Mycena pterigena (Fr.) Kummer, Rimbachia arachnoidea (Peck) Redhead, Russula alnetorum Romagn. i Tremella hypogymniae Diederich & M. S. Christ
Oxidation-induced changes in the surface and structural properties of active carbons
The objective of the study was to investgate how liquid-phase oxidation with H2O2, HClO4 or HNO3 affects the surface and structural properties of active carbons. To evaluate structural prperties use was made of low-temperature-(-196oC)experimental adsorption isotherms of nitrogen measured on unimodified and oxidized carbons.Experimental adsorption isotherms of water vapor ( measured on unimodified and oxidized active carbons at 25o C )were used to determine surface properties.The oxidation process was fuond to influence the parameters the porous structure.This influence was particularly distinct when the samples were oxidized with HNO3at its boiling temperature.The oxidation process also changed the surface properties of the carbons,thus increasing the amount of adsorbed water vapor.In strongly oxidized active carbons samples a change in the adsorption mechanism was observed ( as compared to unmodified or weakly oxidized samples).This observation was confirmed quantitatively by the parameters of the adsorption equations which were used to describe the experimental isotherms.The oxygen groups that form in the course of the oxidation process were fund to alter the mechanism governing water phase formation on the carbon surface.This is reflected by the substantial changes in the adsorption potential distributions due to progressive oxidation of the carbon surface
Some Problems Concerning the Determination of the Impact Resistance of Steel Fibre Reinforced Concrete
Stimulated echo DTI of skeletal muscle in Becker muscular dystrophy: a pilot study
Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas
Multi-center evaluation of stability and reproducibility of quantitative MRI measures in healthy calf muscles
The purpose of this study was to evaluate temporal stability, multi-center reproducibility and the influence of covariates on a multimodal MR protocol for quantitative muscle imaging and to facilitate its use as a standardized protocol for evaluation of pathology in skeletal muscle. Quantitative T2, quantitative diffusion and four-point Dixon acquisitions of the calf muscles of both legs were repeated within one hour. Sixty-five healthy volunteers (31 females) were included in one of eight 3-T MR systems. Five traveling subjects were examined in six MR scanners. Average values over all slices of water-T2 relaxation time, proton density fat fraction (PDFF) and diffusion metrics were determined for seven muscles. Temporal stability was tested with repeated measured ANOVA and two-way random intraclass correlation coefficient (ICC). Multi-center reproducibility of traveling volunteers was assessed by a two-way mixed ICC. The factors age, body mass index, gender and muscle were tested for covariance. ICCs of temporal stability were between 0.963 and 0.999 for all parameters. Water-T2 relaxation decreased significantly (P < 10 −3) within one hour by ~ 1 ms. Multi-center reproducibility showed ICCs within 0.879–0.917 with the lowest ICC for mean diffusivity. Different muscles showed the highest covariance, explaining 20–40% of variance for observed parameters. Standardized acquisition and processing of quantitative muscle MRI data resulted in high comparability among centers. The imaging protocol exhibited high temporal stability over one hour except for water T2 relaxation times. These results show that data pooling is feasible and enables assembling data from patients with neuromuscular diseases, paving the way towards larger studies of rare muscle disorders