Prognozowanie spękań skał przy pracach strzałowych w kopalniach odkrywkowych przy użyciu metod neuronowych i wnioskowania rozmytego (ANFIS) zastosowanych w modelu adaptywnym

Adaptive neuro-fuzzy inference system (ANFIS) is powerful model in solving complex problems. Since ANFIS has the potential of solving nonlinear problem and can easily achieve the input-output mapping, it is perfect to be used for solving the predicting problem. Backbreak is one of the undesirable effects of blasting operations causing instability in mine walls, falling down the machinery, improper fragmentation and reduction in efficiency of drilling. In this paper, ANFIS was applied to predict backbreak in Sangan iron mine of Iran. The performance of the model was assessed through the root mean squared error (RMSE), the variance account for (VAF) and the correlation coefficient (R2) computed from the measured of backbreak and model-predicted values of the dependent variables. The RMSE, VAF, R2 indices were calculated 0.6, 0.94 and 0.95 for ANFIS model. As results, these indices revealed that the ANFIS model has very good prediction performance.Adaptywny system wnioskowania wykorzystujący elementy sieci neuronowych i logiki rozmytej (ANFIS) stanowi potężny narzędzie do rozwiązywania złożonych problemów. Ponieważ model ANFIS może być wykorzystywany do rozwiązywania problemów nieliniowych i umożliwia wygodne przedstawienie problemu w formie: wejście - wyjście, jest idealnym narzędziem do rozwiązywania problemów związanych z prognozowaniem. Pękanie skał w odkrywce jest jednym z niekorzystnych skutków prowadzenia prac strzałowych, powoduje niestabilność ścian, uszkodzenia maszyn i urządzeń, nieodpowiednią fragmentację skał oraz prowadzi do obniżenia efektywności wierceń. W pracy przedstawiono zastosowanie systemu ANFIS do prognozowania pękań skał w kopalni rud żelaza w Sangan (Iran). Działanie modelu zbadano na podstawie wartości błędu średniokwadratowego (RMSE), wariancji (VAF) i współczynnika korelacji (R2) obliczonego na podstawie pomiarów pęknięć skał i wartości uzyskanych z modelowania. Wartości wskaźników RMSE, VAF i R2 obliczonych przy użyciu modelu ANFIS wynoszą odpowiednio 0.6, 0.94 i 0.95. Wielkości te wyraźnie potwierdzają wysoką skuteczność modelu

Proposing a Novel Method for Hardware Trojan Detection

415-418Hardware Trojan refers to an unintended or undesirable alteration in many circuits which turned out to be a major challenge for the design and fabrication of integrated circuits for the semiconductor industries. Such a challenge has been addressed in numerous critical applications. Due to their diversity and process variation, Trojans vary in terms of detection and prevention methods. This paper proposes a novel technique for the Trojan detection involving the application of self-examining circuits. This method adequately resists against the PV and scalability and do not need to any golden ICs. Segmenting the circuit enables the technique to both detect and locate the Trojans with a quick possible time. The implementation of this method indicates a significant improvement in the detection rate

Comparison of hspX gene sequence in the Beijing and non-Beijing Mycobacterium tuberculosis

Purpose: The pathogenicity of various lineages of Mycobacterium tuberculosis (MTB) is different. This could be due to the difference in survival ability within the host macrophage. The alpha crystalline secretion protein, a product of the hspx gene, is one of the bacterial protection factors in these stressful situations. The Beijing family, part of the East Asian lineage, was reported to be more virulent. Regarding the importance of this protein in pathogenicity, this study was conducted to investigate the polymorphism of the hspx gene in Beijing family compared to non- Beijing strains. Method: DNA of 50 MTB isolates were extracted by boiling method. The existence of hspx gene was determined using PCR-specific primer and finally PCR product was sequenced to examine the polymorphism in both direct and reverse directions. Sequencing results were aligned by chromas software. Results: The hspx gene was detected in all of the Beijing and non-Beijing isolates. The polymorphism in the sequences of this gene were not observed in all of the MTB isolates. Discussion: This study indicated that hspx gene is protected. Also it has showed that lineage type was not related to the sequence of hspX gene, but the expression of this protein may be different, which requires further studies. © 202

Achieving to some outranking relationships between post mining land uses through mined land suitability analysis

Adoption of most suitable post mining land use is a problem with multi-dimensional nature. There are so many factors in this problem which seriously influence on the decision judgments. Therefore, in this study a fifty-attribute framework for mined land suitability analysis including fifty numbers of economical, social, technical and mine site factors developed to be a foundation for this decision making problem. Analysis by an outranking multi-attribute decision-making technique, called elimination et choix traduisant la realite method, was taken into consideration because of its clear advantages on the field of mined land suitability analysis as compared with multi-attribute decision-making ranking techniques. Analytical hierarchy process method applied to calculate global weights of the attributes through pair wise comparison matrixes. The weights then passed to the elimination et choix traduisant la realit method so that the most efficient post mining land uses could be appointed through comparisons of pair-wise dominance relationships between alternatives. This approach applied to an illustrative example where, final results showed that, there were two non-dominated land-uses for the considered example; industrial and pasture. However by increasing indifference threshold limit, the non-dominated set reduced to a single alternative that was pasture land-use

Th1-Th17 ratio as a new insight in rheumatoid arthritis disease

The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in comparison with 22 healthy controls, the percentages of Th17, Th1 and dual Th17/Th1 cells were determined by flow-cytometry and their correlations were investigated with disease activity score (DAS28). Moreover, serum levels of IL-6 and IL-17 as inducer and functional cytokines for Th17 were investigated. Finally, serum levels of anti citrullinated protein antibody (ACPA) and rheumatoid factor (RF) were assessed. Percentage of Th17 cells in RA patients were increased in comparison with healthy controls (p<0.01). In correlation with this finding, IL-17 and IL-6 cytokines in RA patients also increased (p<0.01). The Th1 cells in RA patients were less than healthy group (p<0.05) and showed negative correlation with disease activity (r=-0.328, p<0.01). Dual Th17/Th1 cell only in new cases of RA were more than healthy control groups (p<0.01). The Th1/Th17 ratio in RA patients is statistically different with healthy control group (p<0.01) and it has negative correlation with disease activity (r=-264, p<0.05). The levels of ACPA and RF were increased with disease progression. Decreasing of Th1/Th17 ratio in RA patient suggested a new paradigm in the field of autoimmune disease and indicated that imbalance or plasticity between these subsets can be important in progress, diagnosis and therapy of RA disease. © February 2018, Iran J Allergy Asthma Immunol. All rights reserved

Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016-2017

Background: Viruses are considered the most common cause of infectious conjunctivitis. PCR has been approved as the best standard method to diagnose viral conjunctivitis. This study was conducted to investigate epidemiological patterns of conjunctivitis in Hamadan, west Iran. In addition, the frequency of the most important cause of infectious conjunctivitis diagnosed by PCR and its seasonal variations and association with certain socioeconomic and health factors were studied. Methods: In this cross-sectional study, 125 patients with suspected viral conjunctivitis or keratoconjunctivitis in Hamadan, west Iran from July 2016 to June 2017 were examined for the presence of herpes simplex virus 1 (HSV1), HSV2, varicella-zoster virus (VZV), adenovirus. and Chlamydia trachomatis using multiplex real-time PCR. Results: Adenoviruses were the most prevalent pathogens (94.4). HSV1 was found in two (1.6) patients. HSV2, VZV, and C. trachomatis were not seen in any patients. There was no difference in acquisition of conjunctivitis between men and women. A total of 55 (44) patients attended the clinics in summer. Conclusion: This study demonstrated that adenoviruses were a much more common viral cause of conjunctivitis in the studied region compared to findings in other regions. In addition, the acquisition rate of eye infection is expected to decrease dramatically in this region through control of adenoviruses. Demographic variables ie, age, sex, and income level, were not significantly associated with acquisition of viral infection

Dysregulation of helper T lymphocytes in esophageal squamous cell carcinoma (ESCC) patients is highly associated with aberrant production of miR-21

Dysregulation of helper T (Th) cell subsets has been contributed to the initiation and propagation of esophageal squamous cell carcinoma (ESCC). Different microRNAs (miRNAs) have been reported to control the development and functions of tumor-associated immune cells in ESCC. Here, we aimed to assess the IL-10, TGF-β, IFN-γ, and IL-17a-producing CD3+CD8� T cells in association whit miR-21, miR-29b, miR-106a, and miR-155 expression in ESCC patients. A total of 34 ESCC patients including 12 newly diagnosed (ND) and 22 under-treatment (UT) cases and also 34 age-matched healthy donors were enrolled. Flow cytometric characterization of stimulated T cells was performed by staining of the cells with fluorescent conjugated specific anti-human CD3 and CD8 cell surface markers as well as IL-17a, IFN-γ, IL-10, and TGF-β intracytoplasmic cytokines. Circulating RNA was extracted from the plasma, and qRT-PCR was used to evaluate the expression of microRNAs. TGF-β plasma levels were also assessed by ELISA. Results showed that the frequency of Th cells was significantly reduced in patients. A significant increase in Treg as well as Th17 cells population in both patient subgroups was observed. ND patients showed elevated level of Th1 cells and IL-10. However the mean expression of IFN-γ was significantly decreased in Th cells. We also detected higher level of miR-21 in the ESCC patients which was significantly correlated with different subsets of Th cells. Our findings revealed that immune response related to the Th cells is highly impaired in ESCC patients. Association between miR-21 and Th subsets could be correlated with the impairment of anti-tumor immunity and ESCC pathogenesis, which could be potentially used as an important target for immunotherapeutic approaches. © 2019, Springer Science+Business Media, LLC, part of Springer Nature