Motivating young students to be part of the global research in nuclear through the Seminar of Nuclear Fusion

Jóvenes Nucleares (Spanish Young Generation in Nuclear, JJNN) is a non-profit organization that depends on the Spanish Nuclear Society (SNE). The Universidad Politécnica de Madrid (Technical University of Madrid, UPM) was chosen to host the Seminar as it is one of the most prestigious technical universities of Spain, and has a very strong curriculum in nuclear engineering training and research. Both, the UPM and the SNE, supported strongly the seminar: the opening session was conducted by the member of to board of directors of the Spanish Nuclear Society and Nuclear Engineering professor of the UPM, Emilio Mínguez and the closing session was conducted by the director of the Nuclear Fusion Institute (UPM)

LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest

11 páginas, 6 figuras.Members of the Sox family of transcription factors are involved in a number of crucial developmental processes, including sex determination, neurogenesis and skeletal development. LSox5 is a member of the group D Sox factors that, in conjunction with Sox6 and Sox9, promotes chondrogenesis by activating the expression of cartilage-specific extracellular matrix molecules. We have cloned the chicken homologue of LSox5 and found that it is initially expressed in the premigratory and migratory neural crest after Slug and FoxD3. Subsequently, the expression of LSox5 is maintained in cephalic crest derivatives, and it appears to be required for the development of the glial lineage, the Schwann cells and satellite glia in cranial ganglia. Misexpression of LSox5 in the cephalic neural tube activated RhoB expression throughout the dorsoventral axis. Furthermore, the prolonged forced expression of LSox5 enlarged the dorsal territory in which the neural crest is generated, extended the `temporal window' of neural crest segregation, and led to an overproduction of neural crest cells in cephalic regions. In addition to HNK-1, the additional neural crest cells expressed putative upstream markers (Slug, FoxD3) indicating that a regulatory feedback mechanism may operate during neural crest generation. Thus, our data show that in addition to the SoxE genes (Sox9 and Sox10) a SoxD gene (Sox5) also participates in neural crest development and that a cooperative interaction may operate during neural crest generation, as seen during the formation of cartilage.This work was supported by a grant to J.A.B. from the Spanish Ministry of Science and Technology (BMC2002- 00600). S.P.-A. is the recipient of a predoctoral fellowship from the Spanish Ministry of Science and Technology.Peer reviewe

Health Equity Module: The Latino Paradox

This project aims to educate participants about health inequities and the Latinx community, particularly first and second generation immigrants. Participants may be students who plan careers in health care or professionals and community experts new to working with Latinx community members. The module equips participants with foundational knowledge; shares resources for continued learning; and invites participants to reflect critically about their own intersectional identities and how different intersectional identities impact health care experiences

Norfloxacin sesquihydrate

In the crystal structure of the title compound [systematic name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydro­quinoline-3-carboxyl­ate sesquihydrate], C16H18FN3O3·1.42H2O, N—H⋯O and O—H⋯O hydrogen bonds assemble the mol­ecules in a two-dimensional layered corrugated sheet structure parallel to the b axis. The water mol­ecules are disordered [occupancies 0.741 (11) and 0.259 (11)]

Bluetooth Tracking Approach For User Assistance Based In Sequential Patterns Analysis.

As a civilization, we are drowning in a raging torrent of data, of our own making, that is being harvested by our collective technologies and systems (e.g. Fitbit, phones). However, data itself is of no utility unless it is converted into beneficial knowledge. Design patterns have been shown to be a pragmatic solution to control and manage information flows and provide order and mean-ing to data within a given context. Assisting users within their daily activities has become a key aspect for modern Artificial Intelligence Systems. Neverthe-less, although the GPS technologies work well for outside location, indoor posi-tioning is still problematic, while is a vital awareness component in ambient as-sistance. This paper shows a preliminary Bluetooth tracking system with a focus on the user’s transition between areas of interest. Our work aims to shed light on how the term design patterns can be applied for studying human behavior patterns in the smart environment

Recent developments on on-line rheometry to monitor the extrusion process

On-line rheometers are generally inserted between extruder and die and generate data that is typically utilized for quality control purposes. However, on-line rheometers have also the potential to detect changes in structure, morphology, or composition of a given material system, thus assisting materials research and processing optimization, if they can be used along the axis of the extruder or compounder. The authors have previously developed on-line capillary and rotational/oscillatory rheometers that can be inserted and used at specific locations along the extruder. Since these devices are operated manually, their manipulation may be cumbersome and data may lack reliability. This work presents new versions of these rheometers, with improved functionalities and motorized operation. Details on the validation of one of them is also given.This study was carried out within the frame of the MULTIHYBRIDS IP 026685-2IP project, 6th Framework EC Program. The authors also gratefully acknowledge funding by FEDER via FCT, Fundação para a Ciência e Tecnologia, under the POCI 2010 and Plurianual programs

Derisking Development by a Cocrystallization Screen of a Novel Selective Inhaled JAK-STAT inhibitor

The discovery and detailed characterization of several new solid forms of a novel selective inhaled JAK-STAT inhibitor are described. Using a holistic cocrystallization screen approach to explore its formulation landscape, we decrease the risk of future potential development failures due to a nonoptimal pharmacokinetic lung profile or undesired lung effects in humans